DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NAAT1 and Slc6a14

DIOPT Version :9

Sequence 1:	NP_572219.1	Gene:	NAAT1 / 31457	FlyBaseID:	FBgn0029762	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	XP_038955501.1	Gene:	Slc6a14 / 298340	RGDID:	1561810	Length:	646	Species:	Rattus norvegicus

Alignment Length:	627	Identity:	233/627 - (37%)
Similarity:	352/627 - (56%)	Gaps:	45/627 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 ERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENGGGAFLIPYIIVLFLIGKPMYYLEMIMGQF 101
            ||.||....::|:|.:..:||||||||||:..|.||||||||||.|:|.|.|.|:::||..:|||
  Rat    41 ERGNWSKKSDYLLSMVGYAVGLGNVWRFPYLTYTNGGGAFLIPYAIMLALAGLPLFFLECSLGQF 105

  Fly   102 TSQGTVKIWSVVPGFVGVGYGQAFGTICIISYYSSLLALTLYYLFVSFQSELPWSYCRDEWT--N 164
            .|.|.|.:|.::|.|.|||......:|.:..||:.::|.:|||||.||||.|||:.|...|.  |
  Rat   106 ASLGPVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYLFASFQSVLPWANCSSSWADDN 170

  Fly   165 CVNSRPQEYVDNLLTGVSLANESA----RNLSGIVANDET--------EKLQSSSELYFLNVVIK 217
            | :.:|      ::||..::.::.    .|:|.:.:|:.|        ...|..||.|:..|.::
  Rat   171 C-SRQP------IVTGCRVSTDTGGDMFMNISWVNSNNFTCLNGSEVFRPGQLPSEQYWDKVTLR 228

  Fly   218 EKLDISDGVGDPDWKLTLALFVAWVVIFLVIMRGVKSSGKAAYFLALFPYVVLFVLLIRAVTLEG 282
            ....: |..|...|.|.|.|.:||:::...:.:|:|||||..||.||||||||.:||||..||||
  Rat   229 RSSGM-DETGVIVWYLALCLLLAWIIVGAALFKGIKSSGKVVYFTALFPYVVLLILLIRGATLEG 292

  Fly   283 ARDGILFFLEPQ--WGELLNPTVWKEAVVQCFFSLAVGSGPIIMFASYNRFDHGIYRDAMIVTTL 345
            |..||.:::..|  :.:|....|||:|..|.|:||:|..|.::..:|||:|::..|.||:||...
  Rat   293 ASKGISYYIGAQSNFTKLREAEVWKDAATQIFYSLSVAWGGLVALSSYNKFNNNCYSDAIIVCLT 357

  Fly   346 DTLTSLLGGITIFAILGNLAHNLQIENIRDVVRSGTGLAFISYPDAISKFQAVPQLFSVLFFFML 410
            :.|||:..|..||:|||::|| :..:.:..||:||..||||:||:|:::....| .:|:||||||
  Rat   358 NCLTSVFAGFAIFSILGHMAH-ISGKEVSQVVKSGFDLAFIAYPEALAQLPGGP-FWSILFFFML 420

  Fly   411 FVLGIGSIVALQSTIVTIICDQF-KGWKYWKVALTTSVC--GFLMGLVYVTPGGQWILTLVDFYG 472
            ..||:.|..|...||.|.|.|.| |..|..:|.:|...|  .||:|||.||..|.:.:.|:|.:.
  Rat   421 LTLGLDSQFASIETITTTIQDLFPKAMKRMRVPITLGCCLILFLLGLVCVTQAGIYWVHLIDHFC 485

  Fly   473 GTYVVFILAIFELAGIVWVYGLQNFCDDIEFMCNRR---VSLYWRVCWSFFTPVMMIIIFIYSMV 534
            ..:.:.|.||.|:|||:|:||...|.:|||.|...:   ..|:||.||...||:::..|.::|:|
  Rat   486 AGWGILIAAILEIAGIIWIYGGNRFIEDIEMMIGAKRWLFWLWWRACWFVITPILLSAILVWSLV 550

  Fly   535 TIEPIKYSELYFPEAANIAGWLLFAIGAAQFPLWGLWYISRHPQGTYWKSLKASLKPSDRWGPAN 599
            ......|:::.:|:.....||.:........|:..:..|.| .:|...:.:....:|:..|||..
  Rat   551 KFHRPNYADIPYPDWGVALGWCMIIFCIIWIPIMAIIKIVR-AEGNILQRIIKCCRPASNWGPYL 614

  Fly   600 PEIRREWVIFKNQKAAQRATQKDTSKLGFFWRKVANFCGSNK 641
            .:.|.|    :.:..|:.|.:.|        .::....|:.|
  Rat   615 EKHRGE----RYKDMAEPAKETD--------HEIPTISGTRK 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	210/514 (41%)
Slc6a14	XP_038955501.1	SLC6sbd_ATB0	42..645	CDD:271391	232/626 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920