DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NAAT1 and Slc6a6

DIOPT Version :9

Sequence 1:	NP_572219.1	Gene:	NAAT1 / 31457	FlyBaseID:	FBgn0029762	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	XP_008761345.1	Gene:	Slc6a6 / 29464	RGDID:	61912	Length:	631	Species:	Rattus norvegicus

Alignment Length:	624	Identity:	228/624 - (36%)
Similarity:	334/624 - (53%)	Gaps:	72/624 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VQPSNGSSNGSGNGATNAASTEKTDAEKPTAERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYE 70
            ::||.|.|.|:       ...::.|.:.|  :|..|.:.::|::|.....||||||||||:..|:
  Rat    28 LKPSPGKSPGT-------RPEDEADGKPP--QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYK 83

  Fly    71 NGGGAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIW-SVVPGFVGVGYGQAFGTICIIS-- 132
            ||||||||||.|.||..|.|:::||:|:||:||:|.:..| .:.|.|.|:||    .:|.|:|
  Rat    84 NGGGAFLIPYFIFLFGSGLPVFFLEVIIGQYTSEGGITCWEKICPLFSGIGY----ASIVIVSLL 144

  Fly   133 --YYSSLLALTLYYLFVSFQSELPWSYCRDEWTNCVNSRPQEYVDNLLTG----VSLANESARNL 191
              ||..:||...||||.|||.:|||::|...|     :.||...|.|...    |||   ||.|.
  Rat   145 NVYYIVILAWATYYLFQSFQKDLPWAHCNHSW-----NTPQCMEDTLRRNESHWVSL---SAANF 201

  Fly   192 SGIVANDETEKLQSSSELYFLNVVIKEKLDISDGVGDP---DWKLTLALFVAWVVIFLVIMRGVK 253
            :..|.           |.:..||     |.:|.|:..|   .|.|.|.|.:.|:|.|..|.:||:
  Rat   202 TSPVI-----------EFWERNV-----LSLSSGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVR 250

  Fly   254 SSGKAAYFLALFPYVVLFVLLIRAVTLEGARDGILFFLEPQWGELLNPTVWKEAVVQCFFSLAVG 318
            |:||..||.|.||:.:|.|||:|.:||.||.:||.|:|.|....|.:|.||.:|..|.|||.|:.
  Rat   251 STGKVVYFTATFPFAMLLVLLVRGLTLPGAGEGIKFYLYPNISRLEDPQVWIDAGTQIFFSYAIC 315

  Fly   319 SGPIIMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVRSGTGL 383
            .|.:....|||::.:..|||.|::..|::.||.:.|..||:|||.:|....:: |.||..||.||
  Rat   316 LGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVD-IADVAESGPGL 379

  Fly   384 AFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGS-IVALQSTIVTIICDQF-----KGWKYWKVA 442
            |||:||.|:: ...:|..:|:|||.||.:||:.| .|.::..|.::: |.:     ||  |.:..
  Rat   380 AFIAYPKAVT-MMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLV-DLYPSFLRKG--YRREI 440

  Fly   443 LTTSVC--GFLMGLVYVTPGGQWILTLVDFYGGTYVVFI-LAIFELAGIVWVYGLQNFCDDIEFM 504
            ....||  .:|:||..||.||.::..|.|:|..:.|..: :|.||...|.|:||..|..|.||.|
  Rat   441 FIAIVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDM 505

  Fly   505 CNRRVSLYWRVCWSFFTPVMMIIIFIYSMVTIEPIKYSELY-FPEAANIAGWLLFAIGAAQFPLW 568
            ...|...:.:..|:..||.:.:..||:|:|...|:.|:::| :|:.|...||.|........||.
  Rat   506 IGYRPGPWMKYSWAVITPALCVGCFIFSLVKYVPLTYNKVYRYPDWAIGLGWGLALSSMVCIPLV 570

  Fly   569 GLWYISRHPQGTYWKSLKASLKPSD--RWGPANPEIRRE 605
            .:..:.| .:|.....:|..:.|.:  ||.     :.||
  Rat   571 IVILLCR-TEGPLRVRIKYLITPREPNRWA-----VERE 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	200/513 (39%)
Slc6a6	XP_008761345.1	SLC5-6-like_sbd	51..592	CDD:382020	216/574 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820