DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NAAT1 and Slc6a7

DIOPT Version :9

Sequence 1:	NP_572219.1	Gene:	NAAT1 / 31457	FlyBaseID:	FBgn0029762	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	XP_006525992.1	Gene:	Slc6a7 / 240332	MGIID:	2147363	Length:	684	Species:	Mus musculus

Alignment Length:	576	Identity:	229/576 - (39%)
Similarity:	331/576 - (57%)	Gaps:	31/576 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 AERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENGGGAFLIPYIIVLFLIGKPMYYLEMIMGQ 100
            |:|.||...|:||:|||...||||||||||:.||.|||||||:||.::|.:.|.|:::||:.:||
Mouse    82 ADRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQ 146

  Fly   101 FTSQGTVKIWSVVPGFVGVGYGQAFGTICIISYYSSLLALTLYYLFVSFQSELPWSYCRDEWTN- 164
            |:|.|.:.:|.:.|.|.|.|.........:..||:.::|..|:|||.|..|.|||.:|.:.|..
Mouse   147 FSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSNLPWEHCGNWWNTE 211

  Fly   165 -CVNSRPQEYVDNLLTGVSLANESARNLSGIVANDETEKLQSSSELYFLNVVIKEKLDISDGVGD 228
             |:..|..:..:.:|         ..|||..|         |.||.|:...|:  .:..|.|:|.
Mouse   212 LCLEHRGPKSGNGVL---------PLNLSSTV---------SPSEEYWSRYVL--HIQGSQGIGR 256

  Fly   229 PD---WKLTLALFVAWVVIFLVIMRGVKSSGKAAYFLALFPYVVLFVLLIRAVTLEGARDGILFF 290
            |.   |.|.|.|.:|||::||.|::|||||||..||.|.|||::|.:||:|.|||.||..||.|:
Mouse   257 PGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFY 321

  Fly   291 LEPQWGELLNPTVWKEAVVQCFFSLAVGSGPIIMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGI 355
            |.||:..||:..||.||.:|.|:||.||.|.::.|||||.|...||||..|||..:.:||:|.|.
Mouse   322 LTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGF 386

  Fly   356 TIFAILGNLAHNLQIENIRDVVRSGTGLAFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGSIVA 420
            .||::||.::..|.:. :..|.::|.||||:.||.|::.....| .:|.||||||..||:.|..|
Mouse   387 AIFSVLGYMSQELGVP-VDQVAKAGPGLAFVVYPQAMTMLPLSP-FWSFLFFFMLLTLGLDSQFA 449

  Fly   421 LQSTIVTIICDQFKGWKYWKVALTTS---VCGFLMGLVYVTPGGQWILTLVDFYGGTYVVFILAI 482
            ...||||.:.|:|..:...|.|:.:.   |..:||||:..|.||.:.|.|:|.|..::.:.::.|
Mouse   450 FLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVI 514

  Fly   483 FELAGIVWVYGLQNFCDDIEFMCNRRVSLYWRVCWSFFTPVMMIIIFIYSMVTIEPIKYSELYFP 547
            .....:..|||:|.||.||..|...:..||:|.||.|.:|..::.:.:||:|..:|.:|....||
Mouse   515 TTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALLVYSIVKYQPSEYGSYRFP 579

  Fly   548 EAANIAGWLLFAIGAAQFPLWGLWYISRHPQGTYWKSLKASLKPSDRWGPANPEIR 603
            ..|.:.|.|:..:.....|...|..:.|. :|:.|:.|:.:.:|:..|||:..|.|
Mouse   580 AWAELLGILMGLLSCLMIPAGMLVAVLRE-EGSLWERLQQASRPAMDWGPSLEENR 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	206/500 (41%)
Slc6a7	XP_006525992.1	SLC5-6-like_sbd	84..628	CDD:382020	224/566 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920