Protein Alignment NAAT1 and Slc6a6

DIOPT Version :10

• Sequence 1: NP_572219.1
• Gene: NAAT1 / 31457
• FlyBaseID: FBgn0029762
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_033346.2
• Gene: Slc6a6 / 21366
• MGIID: 98488
• Length: 621
• Species: Mus musculus
• Alignment Length: 623
• Identity: 225/623 - (36%)
• Similarity: 337/623 - (54%)
• Gaps: 70/623 - (11%)

  Fly     6 VQPSNGSSNGSGNGATNAASTEKTDAEKPTAERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYE 70
            ::||.|.|.|:       ...::.|.:.|  :|..|.:.::|::|.....||||||||||:..|:
Mouse    18 LKPSPGKSPGT-------RPEDEADGKPP--QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYK 73

  Fly    71 NGGGAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIW-SVVPGFVGVGYGQAFGTICIIS-- 132
            ||||||||||.|.||..|.|:::||:|:||:||:|.:..| .:.|.|.|:||    .:|.|:|
Mouse    74 NGGGAFLIPYFIFLFGSGLPVFFLEVIIGQYTSEGGITCWEKICPLFSGIGY----ASIVIVSLL 134

  Fly   133 --YYSSLLALTLYYLFVSFQSELPWSYCRDEWTNCVNSRPQEYVDNLLTGVSLANESARNLSGIV 195
              ||..:||...||||.|||.:|||::|...|     :.||...|.|          .||.|..|
Mouse   135 NVYYIVILAWATYYLFHSFQKDLPWAHCNHSW-----NTPQCMEDTL----------RRNESHWV 184

  Fly   196 ANDETEKLQSSSELYFLNVVI----KEKLDISDGVGDP---DWKLTLALFVAWVVIFLVIMRGVK 253
                     |.|...|.:.||    :..|.:|.|:.:|   .|.|.|.|.:.|:|.|..|.:||:
Mouse   185 ---------SLSTANFTSPVIEFWERNVLSLSSGIDNPGSLKWDLALCLLLVWLVCFFCIWKGVR 240

  Fly   254 SSGKAAYFLALFPYVVLFVLLIRAVTLEGARDGILFFLEPQWGELLNPTVWKEAVVQCFFSLAVG 318
            |:||..||.|.||:.:|.|||:|.:||.||.:||.|:|.|....|.:|.||.:|..|.|||.|:.
Mouse   241 STGKVVYFTATFPFAMLLVLLVRGLTLPGAGEGIKFYLYPDISRLGDPQVWIDAGTQIFFSYAIC 305

  Fly   319 SGPIIMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVRSGTGL 383
            .|.:....|||::.:..|||.|::..|::.||.:.|..||:|||.:|....:: |.||..||.||
Mouse   306 LGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVD-IADVAESGPGL 369

  Fly   384 AFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGS-IVALQSTIVTIICDQF-----KGW-KYWKV 441
            |||:||.|:: ...:|..:|:|||.||.:||:.| .|.::..|.::: |.:     ||: :...:
Mouse   370 AFIAYPKAVT-MMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLV-DLYPSFLRKGYRREIFI 432

  Fly   442 ALTTSVCGFLMGLVYVTPGGQWILTLVDFYGGTYVVFI-LAIFELAGIVWVYGLQNFCDDIEFMC 505
            |:..|: .:|:||..||.||.::..|.|:|..:.|..: :|.||...|.|:||..|..|.||.|.
Mouse   433 AILCSI-SYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMI 496

  Fly   506 NRRVSLYWRVCWSFFTPVMMIIIFIYSMVTIEPIKYSELY-FPEAANIAGWLLFAIGAAQFPLWG 569
            ..|...:.:..|:..||.:.:..|::|:|...|:.|:::| :|:.|...||.|........||..
Mouse   497 GYRPGPWMKYSWAVITPALCVGCFVFSLVKYVPLTYNKVYRYPDWAIGLGWGLALSSMLCIPLVI 561

  Fly   570 LWYISRHPQGTYWKSLKASLKPSD--RWGPANPEIRRE 605
            :..:.| .:|.....:|..:.|.:  ||.     :.||
Mouse   562 VILLCR-TEGPLRVRIKYLITPREPNRWA-----VERE 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	197/512 (38%)
Slc6a6	NP_033346.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42		7/32 (22%)
		SLC5-6-like_sbd	41..582	CDD:444915	213/573 (37%)