DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NAAT1 and Slc6a6

DIOPT Version :9

Sequence 1:	NP_572219.1	Gene:	NAAT1 / 31457	FlyBaseID:	FBgn0029762	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	XP_030111163.1	Gene:	Slc6a6 / 21366	MGIID:	98488	Length:	631	Species:	Mus musculus

Alignment Length:	623	Identity:	225/623 - (36%)
Similarity:	337/623 - (54%)	Gaps:	70/623 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VQPSNGSSNGSGNGATNAASTEKTDAEKPTAERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYE 70
            ::||.|.|.|:       ...::.|.:.|  :|..|.:.::|::|.....||||||||||:..|:
Mouse    28 LKPSPGKSPGT-------RPEDEADGKPP--QREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYK 83

  Fly    71 NGGGAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIW-SVVPGFVGVGYGQAFGTICIIS-- 132
            ||||||||||.|.||..|.|:::||:|:||:||:|.:..| .:.|.|.|:||    .:|.|:|
Mouse    84 NGGGAFLIPYFIFLFGSGLPVFFLEVIIGQYTSEGGITCWEKICPLFSGIGY----ASIVIVSLL 144

  Fly   133 --YYSSLLALTLYYLFVSFQSELPWSYCRDEWTNCVNSRPQEYVDNLLTGVSLANESARNLSGIV 195
              ||..:||...||||.|||.:|||::|...|     :.||...|.|          .||.|..|
Mouse   145 NVYYIVILAWATYYLFHSFQKDLPWAHCNHSW-----NTPQCMEDTL----------RRNESHWV 194

  Fly   196 ANDETEKLQSSSELYFLNVVI----KEKLDISDGVGDP---DWKLTLALFVAWVVIFLVIMRGVK 253
                     |.|...|.:.||    :..|.:|.|:.:|   .|.|.|.|.:.|:|.|..|.:||:
Mouse   195 ---------SLSTANFTSPVIEFWERNVLSLSSGIDNPGSLKWDLALCLLLVWLVCFFCIWKGVR 250

  Fly   254 SSGKAAYFLALFPYVVLFVLLIRAVTLEGARDGILFFLEPQWGELLNPTVWKEAVVQCFFSLAVG 318
            |:||..||.|.||:.:|.|||:|.:||.||.:||.|:|.|....|.:|.||.:|..|.|||.|:.
Mouse   251 STGKVVYFTATFPFAMLLVLLVRGLTLPGAGEGIKFYLYPDISRLGDPQVWIDAGTQIFFSYAIC 315

  Fly   319 SGPIIMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVRSGTGL 383
            .|.:....|||::.:..|||.|::..|::.||.:.|..||:|||.:|....:: |.||..||.||
Mouse   316 LGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVD-IADVAESGPGL 379

  Fly   384 AFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGS-IVALQSTIVTIICDQF-----KGW-KYWKV 441
            |||:||.|:: ...:|..:|:|||.||.:||:.| .|.::..|.::: |.:     ||: :...:
Mouse   380 AFIAYPKAVT-MMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLV-DLYPSFLRKGYRREIFI 442

  Fly   442 ALTTSVCGFLMGLVYVTPGGQWILTLVDFYGGTYVVFI-LAIFELAGIVWVYGLQNFCDDIEFMC 505
            |:..|: .:|:||..||.||.::..|.|:|..:.|..: :|.||...|.|:||..|..|.||.|.
Mouse   443 AILCSI-SYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMI 506

  Fly   506 NRRVSLYWRVCWSFFTPVMMIIIFIYSMVTIEPIKYSELY-FPEAANIAGWLLFAIGAAQFPLWG 569
            ..|...:.:..|:..||.:.:..|::|:|...|:.|:::| :|:.|...||.|........||..
Mouse   507 GYRPGPWMKYSWAVITPALCVGCFVFSLVKYVPLTYNKVYRYPDWAIGLGWGLALSSMLCIPLVI 571

  Fly   570 LWYISRHPQGTYWKSLKASLKPSD--RWGPANPEIRRE 605
            :..:.| .:|.....:|..:.|.:  ||.     :.||
Mouse   572 VILLCR-TEGPLRVRIKYLITPREPNRWA-----VERE 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	197/512 (38%)
Slc6a6	XP_030111163.1	SLC5-6-like_sbd	51..592	CDD:382020	213/573 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820