DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NAAT1 and Slc6a13

DIOPT Version :9

Sequence 1:	NP_572219.1	Gene:	NAAT1 / 31457	FlyBaseID:	FBgn0029762	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	XP_006237280.2	Gene:	Slc6a13 / 171163	RGDID:	620788	Length:	608	Species:	Rattus norvegicus

Alignment Length:	603	Identity:	216/603 - (35%)
Similarity:	317/603 - (52%)	Gaps:	60/603 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 NGSSNGSGNGATNAAS--TEKTDAEKPTAERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENG 72
            |..|..:.||.|....  .||.: |..|.||..|.|.:||::|.....:|||||||||:..|:||
  Rat     3 NRVSGTTSNGETKPVCPVMEKVE-EDGTLEREQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNG 66

  Fly    73 GGAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIW-SVVPGF------VGVGYGQAFGTICI 130
            ||||.|||:|.||..|.|:::||..:||:|:||.:..| .:.|.|      .|:||........:
  Rat    67 GGAFFIPYLIFLFTCGIPVFFLETALGQYTNQGGITAWRKICPIFEASVPSPGIGYASQMIVSLL 131

  Fly   131 ISYYSSLLALTLYYLFVSFQSELPWSYCRDEWT--NCVNSRPQEYVDNLLTGVSLANESARNLSG 193
            ..||..:||..|:|||.||.::|||..|..||.  |||     |:            :...|...
  Rat   132 NVYYIVVLAWALFYLFSSFTTDLPWGSCSHEWNTENCV-----EF------------QKTNNSLN 179

  Fly   194 IVANDETEKLQSSSELYFLNVVIKEKLDISDGV---GDPDWKLTLALFVAWVVIFLVIMRGVKSS 255
            :.:.:.|..:....|        :..|.||||:   |...|:|.|.|.:||::.:..|.:||||:
  Rat   180 VTSENATSPVIEFWE--------RRVLKISDGIQHLGSLRWELVLCLLLAWIICYFCIWKGVKST 236

  Fly   256 GKAAYFLALFPYVVLFVLLIRAVTLEGARDGILFFLEPQWGELLNPTVWKEAVVQCFFSLAVGSG 320
            ||..||.|.|||::|.|||||.|||.||..||.|:|.|....|.:|.||.:|..|.|||.|:..|
  Rat   237 GKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNITRLWDPQVWMDAGTQIFFSFAICLG 301

  Fly   321 PIIMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVRSGTGLAF 385
            .:....|||::.:..|||.:.:..|::.||.:.|..||:|||.::....:. |.:|..||.||||
  Rat   302 CLTALGSYNKYHNNCYRDCVALCILNSSTSFVAGFAIFSILGFMSQEQGVP-ISEVAESGPGLAF 365

  Fly   386 ISYPDAISKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVTIICDQF-----KGWKYWKVALTT 445
            |:||.|:......| |::..||||:.:||:.|......::||.:.|.:     |..:...:.|..
  Rat   366 IAYPRAVVMLPFSP-LWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVFRKKNRREILILIV 429

  Fly   446 SVCGFLMGLVYVTPGGQWILTLVDFY--GGTYVVFILAIFELAGIVWVYGLQNFCDDIEFMCNRR 508
            ||..|.:||:.:|.||.::..|.|:|  .|..::|: ||||...:.||||...|.|:||.|...:
  Rat   430 SVVSFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFV-AIFESLCVAWVYGASRFYDNIEDMIGYK 493

  Fly   509 VSLYWRVCWSFFTPVMMIIIFIYSMVTIEPIKYSELY-FPEAANIAGWLLFAIGAAQFPLWGLWY 572
            .....:.||.||||.:.:..|::|::...|:.|::.| :|...:..||||........|.|.::.
  Rat   494 PWPLIKYCWLFFTPAVCLATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSIYK 558

  Fly   573 ISRHPQGTYWKSLKASLK 590
            :         ::||..|:
  Rat   559 L---------RTLKGPLR 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	191/511 (37%)
Slc6a13	XP_006237280.2	SLC5-6-like_sbd	32..581	CDD:382020	206/573 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820