Protein Alignment NAAT1 and Slc6a4

DIOPT Version :10

• Sequence 1: NP_572219.1
• Gene: NAAT1 / 31457
• FlyBaseID: FBgn0029762
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_034614.2
• Gene: Slc6a4 / 15567
• MGIID: 96285
• Length: 630
• Species: Mus musculus
• Alignment Length: 621
• Identity: 208/621 - (33%)
• Similarity: 335/621 - (53%)
• Gaps: 68/621 - (10%)

  Fly     4 KGV----------QPSNG----SSNGSGNGATNA--ASTEKTDAEKPTAERTNWGNGLEFLMSCI 52
            |||          |.|||    .|..:|:.|.::  |:|....||....||..||..::||:|.|
Mouse    29 KGVPTPADKAGPGQISNGYSAVPSTSAGDEAPHSTPAATTTLVAEIHQGERETWGKKMDFLLSVI 93

  Fly    53 SVSVGLGNVWRFPFTAYENGGGAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIW-SVVPGF 116
            ..:|.|||:||||:..|:|||||||:||.|:....|.|::|:|:.:||:...|.:.|| .:.|.|
Mouse    94 GYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWKKICPIF 158

  Fly   117 VGVGYGQAFGTICII-----SYYSSLLALTLYYLFVSFQSELPWSYCRDEWT--NCVNSRPQEYV 174
            .|:||     .||||     |||::::|..||||..||..:|||:.|::.|.  ||.|...|
Mouse   159 KGIGY-----AICIIAFYIASYYNTIIAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFAQ--- 215

  Fly   175 DNLLTGVSLANESARNLSGIVANDETEKLQSSS---ELYFLNVV-IKEKLDISDGVGDPDWKLTL 235
            ||:                      |..|.|:|   |.|..:|: |.:...:.| :|...|:|.|
Mouse   216 DNI----------------------TWTLHSTSPAEEFYLRHVLQIHQSKGLQD-LGTISWQLAL 257

  Fly   236 ALFVAWVVIFLVIMRGVKSSGKAAYFLALFPYVVLFVLLIRAVTLEGARDGILFFLEPQWGELLN 300
            .:.:.:.:|:..|.:|||:|||..:..|.|||:||.|||:|..||.||..|::|:|:|.|.:||.
Mouse   258 CIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLE 322

  Fly   301 PTVWKEAVVQCFFSLAVGSGPIIMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLA 365
            ..||.:|..|.||||..|.|.::.|||||:|::..|:||::.:.::.:||.:.|..||.:||.:|
Mouse   323 TGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMA 387

  Fly   366 HNLQIENIRDVVR-SGTGLAFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVTII 429
             .::.|::.:|.: :|..|.||:|.:||:...| ...|:::||.||..||:.|..|....::|.:
Mouse   388 -EMRNEDVSEVAKDAGPSLLFITYAEAIANMPA-STFFAIIFFLMLITLGLDSTFAGLEGVITAV 450

  Fly   430 CDQFKG-W---KYWKVALTTSVCGFLMGLVYVTPGGQWILTLVDFYGGTYVVFILAIFELAGIVW 490
            .|:|.. |   :.|.|.:....| .|..|:.:|.||.:::||::.|.....|..:|:.|...:.|
Mouse   451 LDEFPHIWAKRREWFVLIVVITC-ILGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVVVSW 514

  Fly   491 VYGLQNFCDDIEFMCNRRVSLYWRVCWSFFTPVMMIIIFIYSMVTIEPIKYSELYFPEAANIAGW 555
            .||:..||.|::.|.......:||:||...:|:.::.|....:::...::..:..:|..:.|.|:
Mouse   515 FYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIILGY 579

  Fly   556 LLFAIGAAQFPLWGLWYISRHPQGTYWKSLKASLKP 591
            .:........|::.::.:...| ||..:.:..|:.|
Mouse   580 CIGTSSVICIPIYIIYRLISTP-GTLKERIIKSITP 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	183/509 (36%)
Slc6a4	NP_034614.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		10/33 (30%)
		5HT_transport_N	24..64	CDD:397524	10/34 (29%)
		SLC6sbd_SERT	79..615	CDD:271399	193/571 (34%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624