DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NAAT1 and Slc6a9

DIOPT Version :9

Sequence 1:	NP_572219.1	Gene:	NAAT1 / 31457	FlyBaseID:	FBgn0029762	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001342104.1	Gene:	Slc6a9 / 14664	MGIID:	95760	Length:	652	Species:	Mus musculus

Alignment Length:	615	Identity:	231/615 - (37%)
Similarity:	353/615 - (57%)	Gaps:	38/615 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PSNGSSNG-------SGNGATNAASTEKTDAEKPTAERTNWGNGLEFLMSCISVSVGLGNVWRFP 65
            |...|:.|       ..|||..:.:|:|..    ...|.||||.:||:::.:..:||||||||||
Mouse    13 PGMASAQGPVATPSPEQNGAVPSEATKKDQ----NLTRGNWGNQIEFVLTSVGYAVGLGNVWRFP 73

  Fly    66 FTAYENGGGAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIWSVVPGFVGVGYGQAFGTICI 130
            :..|.||||||:.||.|:|...|.|::::|:..|||.|||.:.:|.:.|.|.|||||....:..|
Mouse    74 YLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYI 138

  Fly   131 ISYYSSLLALTLYYLFVSFQSELPWSYCRDEWT--NCVNSRPQEYVDNLLTGVSLANES-ARNLS 192
            ..||:.::.:..||.|.|....|||:||.:.|.  :|.         .:|...:|.|.| ...||
Mouse   139 GIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTPDCA---------GVLDASNLTNGSRPAALS 194

  Fly   193 GIVAN--DETEKLQSSSELYFLNVVIKEKLDISDGVGD-PDWKLTL--ALFVAWVVIFLVIMRGV 252
            |.:::  :.|.:..|.||.|:...|:|    :||.:|: .:.:|.|  .|.|:|||:||.::|||
Mouse   195 GNLSHLFNYTLQRTSPSEEYWRLYVLK----LSDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGV 255

  Fly   253 KSSGKAAYFLALFPYVVLFVLLIRAVTLEGARDGILFFLEPQWGELLNPTVWKEAVVQCFFSLAV 317
            |||||..||.|.||||||.:|.:|.||||||..||:::|.|||.::|...||.:|..|.|:||..
Mouse   256 KSSGKVVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLTPQWDKILEAKVWGDAASQIFYSLGC 320

  Fly   318 GSGPIIMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVRSGTG 382
            ..|.:|..||||:|.:..|||::|::..:..||:..|..||:|||.:|::|.:: :..|...|.|
Mouse   321 AWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVD-VSRVADHGPG 384

  Fly   383 LAFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVTIICDQF-KGW---KYWKVAL 443
            |||::||:|::.....| |:|:||||||.:||:|:...|..|:||.|.|:. ..|   |...|.|
Mouse   385 LAFVAYPEALTLLPISP-LWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTL 448

  Fly   444 TTSVCGFLMGLVYVTPGGQWILTLVDFYGGTYVVFILAIFELAGIVWVYGLQNFCDDIEFMCNRR 508
            ..:|.|||:|:...:..|.:.|.|:|.|..::.:.:::......|:::||.:|:..||:.|....
Mouse   449 GVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVSIMYIYGHRNYFQDIQMMLGFP 513

  Fly   509 VSLYWRVCWSFFTPVMMIIIFIYSMVTIEPIKYSELYFPEAANIAGWLLFAIGAAQFPLWGLWYI 573
            ..|::::||.|.:|.::..|.|::::...||.|:...:|..|...|:|:........||:.|:.:
Mouse   514 PPLFFQICWRFVSPAIIFFILIFTVIQYRPITYNHYQYPGWAVAIGFLMALSSVICIPLYALFQL 578

  Fly   574 SRHPQGTYWKSLKASLKPSDRWGPANPEIR 603
            .|....|..:.||.:.|||..||||..|.|
Mouse   579 CRTDGDTLLQRLKNATKPSRDWGPALLEHR 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	199/504 (39%)
Slc6a9	NP_001342104.1	SLC6sbd_GlyT1	30..613	CDD:212067	228/598 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820