Protein Alignment NAAT1 and Slc6a12

DIOPT Version :10

• Sequence 1: NP_572219.1
• Gene: NAAT1 / 31457
• FlyBaseID: FBgn0029762
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_598422.2
• Gene: Slc6a12 / 14411
• MGIID: 95628
• Length: 628
• Species: Mus musculus
• Alignment Length: 613
• Identity: 218/613 - (35%)
• Similarity: 326/613 - (53%)
• Gaps: 54/613 - (8%)

  Fly    37 ERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENGGGAFLIPYIIVLFLIGKPMYYLEMIMGQF 101
            :|..|.|.:||::|.....:|||||||||:..|:||||||.|||.|..|..|.|:::||:.:||:
Mouse    49 DRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVALGQY 113

  Fly   102 TSQGTVKIW-SVVPGFVGVGYGQAFGTICIISYYSSLLALTLYYLFVSFQSELPWSYCRDEWT-- 163
            :|||:|..| .:.|...|:|.........:..||..:||..|:|||.||..||||:.|.:.|.
Mouse   114 SSQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTCTNSWNTE 178

  Fly   164 NCVNSRPQEYVDNLLTGVSLANESARNLSGIVANDETEKLQSSSELYFLNVVI----KEKLDISD 224
            :||:              .|.:.|||.:             |||| .|.:.|:    :..|.|:.
Mouse   179 HCVD--------------FLNHSSARGV-------------SSSE-NFTSPVMEFWERRVLGITS 215

  Fly   225 GV---GDPDWKLTLALFVAWVVIFLVIMRGVKSSGKAAYFLALFPYVVLFVLLIRAVTLEGARDG 286
            |:   |...|:|.|.|.:||::.:..|.:||||:||..||.|.|||::|.:||||.|||.||..|
Mouse   216 GIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIILLIRGVTLPGAYQG 280

  Fly   287 ILFFLEPQWGELLNPTVWKEAVVQCFFSLAVGSGPIIMFASYNRFDHGIYRDAMIVTTLDTLTSL 351
            |:|:|:|....|.:|.||.:|..|.|||.|:..|.:....|||::.:..|||::.:..|::.||.
Mouse   281 IVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRDSIALCFLNSATSF 345

  Fly   352 LGGITIFAILGNLAHNLQIENIRDVVRSGTGLAFISYPDAISKFQAVPQLFSVLFFFMLFVLGIG 416
            :.|..:|:|||.::....|. |.:|..||.|||||::|.|:: ...:.||:|.|||.||..||:.
Mouse   346 VAGFVVFSILGFMSQEQGIP-ISEVAESGPGLAFIAFPKAVT-MMPLSQLWSCLFFIMLLFLGLD 408

  Fly   417 SIVALQSTIVTIICDQF-----KGWKYWKVALTTSVCGFLMGLVYVTPGGQWILTLVDFYGGTYV 476
            |.......:||...|.|     |..:...:.|..||..:||||:.||.||.:|..|.|:|..:.:
Mouse   409 SQFVCMECLVTASMDMFPQQLRKSGRRELLILAISVLCYLMGLLLVTEGGMYIFQLFDYYASSGI 473

  Fly   477 -VFILAIFELAGIVWVYGLQNFCDDIEFMCNRRVSLYWRVCWSFFTPVMMIIIFIYSMVTIEPIK 540
             :..|::||:..|.||||...|.|::|.|...|.....::.|.|.||.:.:..|.:|:....|:|
Mouse   474 CLLFLSLFEVICIGWVYGADRFYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPLK 538

  Fly   541 YSELY-FPEAANIAGWLLFAIGAAQFPLWGLWYISRHPQGTYWKSLKASLKPSDRWGPANPEIRR 604
            |:.:| :|......||||.....|..||:.:....: .||::.|.|:..:.|.    |:.|:..|
Mouse   539 YNNVYMYPSWGYSIGWLLAFSSMACVPLFIIITFLK-TQGSFKKRLRRLITPD----PSLPQPGR 598

  Fly   605 EWVIFKNQKAAQRATQKDTSKLGFFWRK 632
            ...  ::..:||..:.....:....|.|
Mouse   599 RPP--QDGSSAQNCSSSPAKQELIAWEK 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	192/508 (38%)
Slc6a12	NP_598422.2	SLC5-6-like_sbd	49..589	CDD:444915	210/570 (37%)