DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NAAT1 and Slc6a20

DIOPT Version :9

Sequence 1:	NP_572219.1	Gene:	NAAT1 / 31457	FlyBaseID:	FBgn0029762	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_579830.1	Gene:	Slc6a20 / 113918	RGDID:	621651	Length:	616	Species:	Rattus norvegicus

Alignment Length:	626	Identity:	196/626 - (31%)
Similarity:	308/626 - (49%)	Gaps:	121/626 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DAEKPTAERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENGGGAFLIPYIIVLFLIGKPMYYL 94
            |.||   .|..|||.|:|:.:|||.:||||||||||:.....|||:||:||:|:|.:.|.|:.||
  Rat    24 DMEK---ARPQWGNPLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYLIMLIVEGMPLLYL 85

  Fly    95 EMIMGQFTSQGTVKIW-SVVPGFVGVGYGQAFGTICIISYYSSLLALTLYYLFVSFQSELPWSYC 158
            |:.:||...||::..| ::.|...|||......:..:..||:.:.|...:|||.|||..||||.|
  Rat    86 ELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWGFWYLFHSFQDPLPWSVC 150

  Fly   159 RDEWTNCVNSRPQEYVDNLLTGVSLANESARNLSGIVANDETEKLQSSSELYFLNVVIKEKLDIS 223
            .      :||....|                       ::|.||..|:...::     ::.|:||
  Rat   151 P------LNSNRTGY-----------------------DEECEKASSTQYFWY-----RKTLNIS 181

  Fly   224 DGV---GDPDWKLTLALFVAWVVIFLVIMRGVKSSGKAAYFLALFPYVVLFVLLIRAVTLEGARD 285
            ..:   |...|:..|.|.:||::::|.|:||.:|:||..||.||.||.||.:.|:|.:||.||.:
  Rat   182 PSIQENGGVQWEPALCLTLAWLMVYLCILRGTESTGKVVYFTALMPYCVLIIYLVRGLTLHGATN 246

  Fly   286 GILFFLEPQWGELLNPTVWKEAVVQCFFSLAVGSGPIIMFASYNRFDHGIYRDAMIVTTLDTLTS 350
            |:::...|:..:|.||..|..|..|.||||.:|.|.:|.|||||...:...:.|:||:.:::.||
  Rat   247 GLMYMFTPKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNDCQKHAVIVSVINSSTS 311

  Fly   351 LLGGITIFAILG--------NLAHNL------------------QIENIRDVVRS---------- 379
            :...|..|:|.|        |..:.:                  .:|.::|.:.|
  Rat   312 IFASIVTFSIYGFKATFNYENCLNKVILLLTNSFDLEDGFLTASNLEEVKDYLASTYPNKYSEVF 376

  Fly   380 -----------------GTGLAFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVT 427
                             |||||||.|.:||...: |.||:|||:||||.:||:||::...:.|:|
  Rat   377 PHIRNCSLESELNTAVQGTGLAFIVYAEAIKNME-VSQLWSVLYFFMLLMLGMGSMLGNTAAILT 440

  Fly   428 IICDQFKGWKYW-KVALTTSVC--GFLMGLVYVTPGGQWILTLVDFYGGTYVVFILAIFELAGIV 489
            .:.|......|. |.|::..||  ...:|:|:....|.:...:.:.|..|..:.::.:.|...:.
  Rat   441 PLTDSKVISSYLPKEAISGLVCLINCAVGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVC 505

  Fly   490 WVYGLQNFCDDIEFMCNRRVSLYWRVCWSFFTPVMMIIIFIYSM---VTIEPIKY---------- 541
            :||||:.|..|:..|..|.::.||:..|:|.:|:::|.:||:.:   :....::|
  Rat   506 YVYGLRRFESDLRAMTGRPLNWYWKAMWAFVSPLLIIGLFIFYLSDYILTGTLQYQAWDATQGQL 570

  Fly   542 -SELYFPEAANIAGWLLFAIGAAQFPLWGLWYISRHPQGTY 581
             ::.|.|.|..:.| ||.|......||..|        ||:
  Rat   571 VTKDYPPHALAVIG-LLVASSTMCIPLVAL--------GTF 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	179/552 (32%)
Slc6a20	NP_579830.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		1/1 (100%)
Slc6a20	NP_579830.1	SLC5-6-like_sbd	26..601	CDD:294310	193/621 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810