DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NAAT1 and Slc6a20a

DIOPT Version :9

Sequence 1:	NP_572219.1	Gene:	NAAT1 / 31457	FlyBaseID:	FBgn0029762	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_631881.1	Gene:	Slc6a20a / 102680	MGIID:	2143217	Length:	592	Species:	Mus musculus

Alignment Length:	618	Identity:	195/618 - (31%)
Similarity:	302/618 - (48%)	Gaps:	118/618 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 RTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENGGGAFLIPYIIVLFLIGKPMYYLEMIMGQFT 102
            |..||:.|:|:.:|||.:||||||||||:.....|||:||:||||:|.:.|.|:.|||:.:||..
Mouse     5 RPQWGHPLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQRM 69

  Fly   103 SQGTVKIW-SVVPGFVGVGYGQAFGTICIISYYSSLLALTLYYLFVSFQSELPWSYCRDEWTNCV 166
            .||::..| ::.|...|||......:..:..||:.:.|...:|||.|||..||||.|.      :
Mouse    70 RQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWGFWYLFHSFQDPLPWSVCP------L 128

  Fly   167 NSRPQEYVDNLLTGVSLANESARNLSGIVANDETEKLQSSSELYFLNVVIKEKLDISDGV---GD 228
            ||....|                       ::|.||..|:...::     ::.|:||..:   |.
Mouse   129 NSNHTGY-----------------------DEECEKASSTQYFWY-----RKTLNISPSIQENGG 165

  Fly   229 PDWKLTLALFVAWVVIFLVIMRGVKSSGKAAYFLALFPYVVLFVLLIRAVTLEGARDGILFFLEP 293
            ..|:..|.|.:||::::|.|:||.:|:||..||.|..||.||.:.|:|.:||.||.:|:::...|
Mouse   166 VQWEPALCLTLAWLMVYLCILRGTESTGKVVYFTASMPYCVLIIYLVRGLTLHGATNGLMYMFTP 230

  Fly   294 QWGELLNPTVWKEAVVQCFFSLAVGSGPIIMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIF 358
            :..:|.||..|..|..|.||||.:|.|.:|.|||||...:...:.|:||:.:::.||:...|..|
Mouse   231 KMEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSIINSSTSIFASIVTF 295

  Fly   359 AILG--------------------------------NL---------------------AHNLQI 370
            :|.|                                ||                     ..|..:
Mouse   296 SIYGFKATFNYENCLNKVILLLTNSFDLEDGFLTVSNLEEVKNYLASTYPNKYSEVFPHIRNCSL 360

  Fly   371 ENIRDVVRSGTGLAFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVTIICDQFKG 435
            |:..|....|||||||.|.:||...: |.||:|||:||||.:|||||::...:.|:|.:.|....
Mouse   361 ESELDTAVQGTGLAFIVYTEAIKNME-VSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKVI 424

  Fly   436 WKYW-KVALTTSVC--GFLMGLVYVTPGGQWILTLVDFYGGTYVVFILAIFELAGIVWVYGLQNF 497
            ..|. |.|::..||  ...:|:|:....|.:...:.:.|..|..:.::.:.|...:.:||||:.|
Mouse   425 SSYLPKEAISGLVCLINCAVGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLKRF 489

  Fly   498 CDDIEFMCNRRVSLYWRVCWSFFTPVMMIIIFIYSM---VTIEPIKY-----------SELYFPE 548
            ..|:..|..|.:|.||:|.|:|.:|::::.:||:.:   :....::|           ::.|.|.
Mouse   490 ESDLRAMTGRTLSWYWKVMWAFVSPLLIVGLFIFYLSDYILTGTLQYQAWDATQGQLVTKDYPPH 554

  Fly   549 AANIAGWLLFAIGAAQFPLWGLWYISRHPQGTY 581
            |..:.| ||.|......||..|        ||:
Mouse   555 ALAVIG-LLVASSTMCIPLVAL--------GTF 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	181/552 (33%)
Slc6a20a	NP_631881.1	SLC5-6-like_sbd	2..577	CDD:294310	193/615 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810