DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NAAT1 and slc6a7

DIOPT Version :9

Sequence 1:	NP_572219.1	Gene:	NAAT1 / 31457	FlyBaseID:	FBgn0029762	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	XP_002940131.3	Gene:	slc6a7 / 100487063	XenbaseID:	XB-GENE-479449	Length:	634	Species:	Xenopus tropicalis

Alignment Length:	587	Identity:	233/587 - (39%)
Similarity:	336/587 - (57%)	Gaps:	42/587 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DAEKPTAERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENGGGAFLIPYIIVLFLIGKPMYYL 94
            |.|.| .:|.||...|:||:|||...||||||||||:.||.||||||||||.|:|.:.|.|::::
Frog    30 DIEYP-EDRGNWSGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLIPYFIMLAICGIPLFFM 93

  Fly    95 EMIMGQFTSQGTVKIWSVVPGFVGVGYGQAFGTICIISYYSSLLALTLYYLFVSFQSELPWSYCR 159
            |:.:|||:|.|.:.:|.:.|.|.|||.|.......:..||:.::|..|:|||.|..|.|||.:|.
Frog    94 ELSLGQFSSLGPLAVWKISPLFKGVGMGMLLIVALVAIYYNMIIAYVLFYLFASLTSSLPWEHCG 158

  Fly   160 DEWTN--CVNSRPQEYVDNLLTGVSLANESAR--NLSGIVANDETEKLQSSSELYFLNVVIKEKL 220
            :.|..  |::..           |..|:.||.  |:|..|         |.||.|:...|:  .:
Frog   159 NWWNTDLCLDHH-----------VIRASNSALLVNISNTV---------SPSEEYWSRYVL--HI 201

  Fly   221 DISDGVGDPD---WKLTLALFVAWVVIFLVIMRGVKSSGKAAYFLALFPYVVLFVLLIRAVTLEG 282
            ..|.|:|||.   |||.|.|.::|.:::|.|::|||||||..||.|.|||::|.:||||.|||||
Frog   202 QGSSGIGDPGQLRWKLCLCLLLSWTIVYLCILKGVKSSGKVVYFTATFPYIILVMLLIRGVTLEG 266

  Fly   283 ARDGILFFLEPQWGELLNPTVWKEAVVQCFFSLAVGSGPIIMFASYNRFDHGIYRDAMIVTTLDT 347
            |..||.|:|.||:..||...||.||.:|.|:||.||.|.::.|||||.|...||||..|||..:.
Frog   267 AWIGIKFYLTPQFEHLLTSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNA 331

  Fly   348 LTSLLGGITIFAILGNLAHNLQIENIRDVVRSGTGLAFISYPDAISKFQAVPQLFSVLFFFMLFV 412
            .||:|.|..||::||.::..|.:. :..|.::|.||||:.||.|::.....| .:|.||||||..
Frog   332 FTSILAGFAIFSVLGYMSQELGVP-VDQVAKAGPGLAFVVYPQAMTMLPLSP-FWSFLFFFMLLT 394

  Fly   413 LGIGSIVALQSTIVTIICDQFKGWKYW----KVALTTSVCG--FLMGLVYVTPGGQWILTLVDFY 471
            ||:.|..|...||||.|.|:|   .|:    |...:..:|.  ||:||:..|.||.:.|.|:|.|
Frog   395 LGLDSQFAFMETIVTAITDEF---PYYLRPKKAVFSAIICVALFLLGLILATDGGMYWLVLLDDY 456

  Fly   472 GGTYVVFILAIFELAGIVWVYGLQNFCDDIEFMCNRRVSLYWRVCWSFFTPVMMIIIFIYSMVTI 536
            ...:.:.::.|.....:..|||::|||.||:.|...:..||::.||.|.:||.::.:..||::..
Frog   457 SAGFGLLVIVITFCLSVSRVYGIKNFCRDIQMMLGFKPGLYFKACWIFLSPVTLMCLLAYSILKY 521

  Fly   537 EPIKYSELYFPEAANIAGWLLFAIGAAQFPLWGLWYISRHPQGTYWKSLKASLKPSDRWGPANPE 601
            :|.:|....||..:...|.|:..:.....|: |:.......:|:.|:.::.:.:|:..|||:..|
Frog   522 QPSQYGSYKFPLWSEALGILMGLLSCMMIPI-GMLVAILKEEGSLWERIRQASRPAMDWGPSMEE 585

  Fly   602 IR 603
            .|
Frog   586 NR 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	212/505 (42%)
slc6a7	XP_002940131.3	SLC5-6-like_sbd	37..581	CDD:382020	226/571 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110