DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NAAT1 and slc6a14

DIOPT Version :9

Sequence 1:	NP_572219.1	Gene:	NAAT1 / 31457	FlyBaseID:	FBgn0029762	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001313379.1	Gene:	slc6a14 / 100150665	ZFINID:	ZDB-GENE-130411-2	Length:	614	Species:	Danio rerio

Alignment Length:	605	Identity:	221/605 - (36%)
Similarity:	337/605 - (55%)	Gaps:	40/605 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LKGVQPSNGSSNGSGNGATNAASTEKTDAEKPTAERTNWGNGLEFLMSCISVSVGLGNVWRFPFT 67
            ::||...|  |.|.......:...|........::|.||.:..|:::|.|..:||||||||||:.
Zfish     9 IRGVLFKN--SVGDEQDKDKSDKAEHVVQNDENSDRGNWSSKREYMLSMIGYAVGLGNVWRFPYL 71

  Fly    68 AYENGGGAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIWSVVPGFVGVGYGQAFGTICIIS 132
            ||::|||||||||.|:|.:.|.|::::|...|||.|||.:.:|..||...|||......:..:..
Zfish    72 AYKHGGGAFLIPYTIMLAVSGLPLFFMESSFGQFCSQGPINVWKAVPILQGVGITMMLVSTFVAI 136

  Fly   133 YYSSLLALTLYYLFVSFQSELPWSYCRDEWTNCVNSRPQEYVDNLLTGVSLANESARNLSGIVAN 197
            ||:.::|.::||||.|||..||||.     .||                   |.:|.|:|....|
Zfish   137 YYNVIIAYSIYYLFASFQDPLPWSI-----KNC-------------------NTTASNISTAAVN 177

  Fly   198 DETEKL--QSSSELYFLNVVIKEKLDISDGVGDPDWKLTLALFVAWVVIFLVIMRGVKSSGKAAY 260
            ....::  ||.||.|:..|.::....: |..|...|.|.|.|.::|:::...:.:|:|||||..|
Zfish   178 VSCGQISGQSLSEKYWDEVALQRSSSM-DETGPVVWHLALCLLLSWILVGAALFKGIKSSGKVVY 241

  Fly   261 FLALFPYVVLFVLLIRAVTLEGARDGILFFLEPQWG--ELLNPTVWKEAVVQCFFSLAVGSGPII 323
            |.|.|||:||.:||||..|||||:|||.|::..|..  :|....|||:|..|.||||::..|.::
Zfish   242 FTATFPYIVLLILLIRGATLEGAKDGIEFYIGSQSNLTKLAEAEVWKDAATQIFFSLSIAWGGLM 306

  Fly   324 MFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVRSGTGLAFISY 388
            ..:|||:|.:..|:|:::|...:..||:..|..||::||::||..| ..:.:|..:|..||||:|
Zfish   307 ALSSYNKFYNNCYQDSIVVCVTNCGTSIFAGFAIFSVLGHMAHVYQ-RPVSEVADAGFALAFIAY 370

  Fly   389 PDAISKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVTIICDQF-KGWKYWKVALTTSVC--GF 450
            |||:||....| |:|:||||||..||:.|..|....|.|.:.|.: :..|..:..:||:||  .|
Zfish   371 PDALSKLPISP-LWSILFFFMLITLGLDSQFAGIEVISTCLLDAYPEVLKSKRGLVTTAVCIILF 434

  Fly   451 LMGLVYVTPGGQWILTLVDFYGGTYVVFILAIFELAGIVWVYGLQNFCDDIEFMCNRRVSLY--- 512
            |:||..||..|.:.:.|:|.:...:::.:..:.|:.|:..:||...|..|||.|...:.||:
Zfish   435 LLGLPCVTRAGIYWVNLIDTFSAGWILLVAGLLEVLGLCILYGGNRFIKDIEMMIGTKSSLFWLW 499

  Fly   513 WRVCWSFFTPVMMIIIFIYSMVTIEPIKYSELYFPEAANIAGWLLFAIGAAQFPLWGLWYISRHP 577
            ||.||.|.|||::.||.|:|:.|.....||.:.:|:.....||.:.|......|:..:|.:.: .
Zfish   500 WRACWFFITPVVLSIILIWSLYTFTSPTYSSVAYPDWGISLGWCITAFSLMWIPIVAVWKVCK-A 563

  Fly   578 QGTYWKSLKASLKPSDRWGP 597
            :|..|:.:|::..|::.|||
Zfish   564 RGGLWQRIKSACSPTEDWGP 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	197/502 (39%)
slc6a14	NP_001313379.1	SLC6sbd_ATB0	42..612	CDD:271391	215/570 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920