DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SK and kcnn3

DIOPT Version :9

Sequence 1:	NP_001284887.1	Gene:	SK / 31456	FlyBaseID:	FBgn0029761	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	XP_001921794.2	Gene:	kcnn3 / 570138	ZFINID:	ZDB-GENE-100921-56	Length:	771	Species:	Danio rerio

Alignment Length:	835	Identity:	352/835 - (42%)
Similarity:	480/835 - (57%)	Gaps:	146/835 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 MATMTNNQQQQQ----PTISIMNLSLK---PGDSHSHSSSPGSHPNLGTSSYQNLASSIPPSVPS 219
            :|.::.::.::|    |...|.:.||.   ||.:||:.:.       |.||.:.|..:..|:.|:
Zfish     9 LALLSGSEDEEQRLPLPLGGISHASLSGNYPGTNHSNHTG-------GNSSLERLNGTPSPTTPN 66

  Fly   220 RCRACRNCSRRASTTPTTLIDRSASRDSVKSAFQQGNLSGSMAICISNSALPQQQQLQQQYHLQQ 284
            ...|... ....||||                    .||..:...:..::.|....|..|:.|..
Zfish    67 LPPASLP-KLPLSTTP--------------------QLSTPIPNALHPTSTPLSSCLGSQHSLSG 110

  Fly   285 QQQQHYQLQQHHLHQQQLQQSQQQVPPVLITSSPTNGSRIIRQSSQPESSSTAICCGPHSACVGH 349
            :....|....:..|....::.:::                                  ...|
Zfish   111 ETSPVYNALFYSSHSPSTERERER----------------------------------ERGC--- 138

  Fly   350 AHSHSHTVPNVSLKQLRESSGDGIAGIAADSLRINGG-MRPFKQLRKPASTL--SIPGSMKTPSI 411
              .|....|   |...|:|  :....||..|.:.:|| |:|..:|......|  |..||......
Zfish   139 --KHRQASP---LVHRRDS--NPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIESDSGSDTKEGG 196

  Fly   412 ANREQISSGCNEEA-------AEALVGIHSDYPR---------------YMEERALT-------- 446
            |:..|:::..::.:       .|.::....|.|.               |.:..||:
Zfish   197 ASTSQVTAASSQHSQPQPQNPPEIVISSKEDPPYGHAYELEASANQMSIYHQNHALSESRSVLGG 261

  Fly   447 ---GGNTSRK------PSTNSAK----HKPNVGYRLGKRKALFEKRKRISDYALVMGMFGIIVMV 498
               ||...|:      |...::|    ...|:||:||.|:||||||||:|||||:.|||||:|||
Zfish   262 AAGGGTNGRRGGAAGGPGRTASKAPKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMV 326

  Fly   499 IENELSSAGVYTKASFYSTALKTLISVSTVILLGLIVAYHALEVQVRLFMIDNCADDWRIAMTWQ 563
            ||.|| |.|||:|:|.||.|||.|||:||:||||||:||||.|||  ||:|||.|||||||||.:
Zfish   327 IETEL-SWGVYSKSSMYSLALKCLISLSTIILLGLIIAYHAREVQ--LFVIDNGADDWRIAMTME 388

  Fly   564 RISQIGLELFICAIHPIPGEYYFQWTTKLANKNKTIGTEMVPYDVALSLPMFLRLYLICRVMLLH 628
            |:..|.|||.:.|:||:||::.|.|..:||........| ...|:.||:|||||||||.||||||
Zfish   389 RVLLIALELIVSAVHPVPGDFKFMWRARLAFSYAPSQAE-ADLDMVLSVPMFLRLYLIARVMLLH 452

  Fly   629 SKLFTDASSRSIGALNRINFNTRFVLKTLMTICPGTVLLVFMVSLWIIASWTLRQCERFHDEEH- 692
            ||||||||||||||||:::||||||:|||||||||||||||.:||||||:||:|.|||:||.:.
Zfish   453 SKLFTDASSRSIGALNKVHFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDAQDV 517

  Fly   693 -ANLLNAMWLIAITFLSVGFGDIVPNTYCGRGIAVSTGIMGAGCTALLVAVVSRKLELTRAEKHV 756
             :|.|.|||||:|||||:|:||:||:||||:|:.:.|||||||||||:||||:||||||:|||||
Zfish   518 TSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHV 582

  Fly   757 HNFMMDTQLTKRLKNAAANVLRETWLIYKHTRLVKRVNPGRVRTHQRKFLLAIYALRKVKMDQRK 821
            ||||||||||||:||||||||||||||||||:|:|:::..|||.||||||.||:.||.|||:|||
Zfish   583 HNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLMKKIDHSRVRKHQRKFLQAIHQLRSVKMEQRK 647

  Fly   822 LMDNANTITDMAKTQNTVYEIISDMSSRQDAIEERLTNLEDKMQSIQEHMESLPDLLSRCL-TQH 885
            |.|.|||:.|::|.|:.:||::|:::.|.:.:|.::.:||.:::.:.....:||..||..| :||
Zfish   648 LSDQANTLVDLSKMQSVMYELMSELNDRSEDLERQMLSLEQRVERLTAGFNALPAHLSATLSSQH 712

  Fly   886 QERIEQRRNFLHPDTAAVAP----IQAPTPQSMFNAAPMLFPHS---SVPSSNNA 933
            ...::..|   ..|...::|    ..:||..|:    |:..|.|   |:||:..|
Zfish   713 AALVQLLR---ERDAKVLSPTVPSALSPTAASL----PLANPPSGSGSIPSTQPA 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SK	NP_001284887.1	SK_channel	472..582	CDD:281522	77/109 (71%)
		Ion_trans_2	669..748	CDD:285168	54/80 (68%)
		CaMBD	762..834	CDD:280961	52/71 (73%)
kcnn3	XP_001921794.2	SK_channel	300..407	CDD:281522	77/109 (71%)
		Ion_trans_2	495..574	CDD:285168	53/78 (68%)
		CaMBD	588..660	CDD:280961	52/71 (73%)
		TDA11	<623..>764	CDD:293689	54/145 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583574
Domainoid	1	1.000	166	1.000	Domainoid score	I3827
eggNOG	1	0.900	-	-		E1_KOG3684
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	579	1.000	Inparanoid score	I994
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265878at33208
OrthoFinder	1	1.000	-	-		FOG0001440
OrthoInspector	1	1.000	-	-		otm24811
orthoMCL	1	0.900	-	-		OOG6_102955
Panther	1	1.100	-	-	O	PTHR10153
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1159
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.760