DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SK and kcnn2

DIOPT Version :9

Sequence 1:	NP_001284887.1	Gene:	SK / 31456	FlyBaseID:	FBgn0029761	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	XP_693120.4	Gene:	kcnn2 / 564698	ZFINID:	ZDB-GENE-091116-41	Length:	677	Species:	Danio rerio

Alignment Length:	668	Identity:	338/668 - (50%)
Similarity:	445/668 - (66%)	Gaps:	77/668 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 QLQQQYHLQQQQQQHYQLQQHHLHQQQ--------------LQQSQQQVP----PV--LITSSPT 319
            |||..::.:||||||.: .||:..:::              .:.:::..|    |:  |.|.|.:
Zfish     6 QLQNNFYPEQQQQQHCK-YQHYCGREEERSIRHCTCNNSSTCEDARKSQPLHGTPLGTLRTPSVS 69

  Fly   320 NGSRIIRQSSQPESSSTAICCGPHSACVGHAHSHSHTVPNVSLKQLRES------SGDGIAGIAA 378
            :.:|...|.|:...||..      |:...|.|.|.|...:.:.:|:|.|      ..:....||.
Zfish    70 SSTRQGAQYSEFTPSSHG------SSSRHHHHHHHHPHRDHNRQQIRGSPASSHRESNSYTQIAM 128

  Fly   379 DSLRINGG-MRPFKQLRKPASTLSIPGSMKTPSIANREQISSGCNEEAAEALVGIHSDYPRYMEE 442
            .|.|.||| |||...|......|....|...|    .:.:|:.   :|::.|    :..|   |.
Zfish   129 SSCRYNGGVMRPLSNLSSSRRNLHEFDSESQP----LQPVSAA---DASDTL----ASKP---EN 179

  Fly   443 RALT--------------GGNTSRKPSTNSAKHKPNVGYRLGKRKALFEKRKRISDYALVMGMFG 493
            .:.|              ||..|...|.:..|...|:|.:||.|:||||||||:|||||:.||||
Zfish   180 NSSTLMPYATGDGGGGGGGGGCSHSGSKSGKKKNQNIGQKLGHRRALFEKRKRLSDYALIFGMFG 244

  Fly   494 IIVMVIENELSSAGVYTKASFYSTALKTLISVSTVILLGLIVAYHALEVQVRLFMIDNCADDWRI 558
            |:|||||.|| |.|.|.|.|.||.|||.|||:||:||||||:.|||.|:|  |||:||.||||||
Zfish   245 IVVMVIETEL-SWGAYGKESLYSLALKCLISLSTIILLGLIIIYHAREIQ--LFMVDNAADDWRI 306

  Fly   559 AMTWQRISQIGLELFICAIHPIPGEYYFQWTTKLANKNKTIGTEMVPYDVALSLPMFLRLYLICR 623
            |||::||..|.||:.:||||||||.|.|.||.:||.......|: ...|:.||:|||||||||.|
Zfish   307 AMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSKTD-ADVDIILSIPMFLRLYLIAR 370

  Fly   624 VMLLHSKLFTDASSRSIGALNRINFNTRFVLKTLMTICPGTVLLVFMVSLWIIASWTLRQCERFH 688
            |||||||||||||||||||||:||||||||:|||||||||||||||.:||||||:||:|.|||:|
Zfish   371 VMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFTISLWIIAAWTVRACERYH 435

  Fly   689 D--EEHANLLNAMWLIAITFLSVGFGDIVPNTYCGRGIAVSTGIMGAGCTALLVAVVSRKLELTR 751
            |  :..:|.|.|||||:||||::|:||:|||||||:|:.:.|||||||||||:||||::|||||:
Zfish   436 DNMDVTSNFLGAMWLISITFLTIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVAKKLELTK 500

  Fly   752 AEKHVHNFMMDTQLTKRLKNAAANVLRETWLIYKHTRLVKRVNPGRVRTHQRKFLLAIY---ALR 813
            |||||||||||||||||:||.|||||||||||||:|:||::::..:||.||||||.||:   .||
Zfish   501 AEKHVHNFMMDTQLTKRVKNTAANVLRETWLIYKNTKLVRKMDHAKVRKHQRKFLQAIHQARKLR 565

  Fly   814 KVKMDQRKLMDNANTITDMAKTQNTVYEIISDMSSRQDAIEERLTNLEDKMQSIQEHMESLPDLL 878
            .|||:||||.|.||::.|:|||||.:|:::||::.|.:.:|:|:..||.|::::..::::||.|:
Zfish   566 SVKMEQRKLNDQANSLVDLAKTQNVMYDLVSDLNERGEDMEKRIALLETKLETLLSNLQALPGLI 630

  Fly   879 SRCLTQHQERIEQRRNFL 896
            |:.::|      |.|:||
Zfish   631 SQVISQ------QHRDFL 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SK	NP_001284887.1	SK_channel	472..582	CDD:281522	77/109 (71%)
		Ion_trans_2	669..748	CDD:285168	53/80 (66%)
		CaMBD	762..834	CDD:280961	48/74 (65%)
kcnn2	XP_693120.4	SK_channel	223..330	CDD:281522	77/109 (71%)
		Ion_trans_2	416..497	CDD:285168	53/80 (66%)
		CaMBD	511..589	CDD:198121	51/77 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583572
Domainoid	1	1.000	166	1.000	Domainoid score	I3827
eggNOG	1	0.900	-	-		E1_KOG3684
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	579	1.000	Inparanoid score	I994
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265878at33208
OrthoFinder	1	1.000	-	-		FOG0001440
OrthoInspector	1	1.000	-	-		otm24811
orthoMCL	1	0.900	-	-		OOG6_102955
Panther	1	1.100	-	-	LDO	PTHR10153
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4617
SonicParanoid	1	1.000	-	-		X1159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.830