DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SK and Kcnn3

DIOPT Version :9

Sequence 1:	NP_001284887.1	Gene:	SK / 31456	FlyBaseID:	FBgn0029761	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	NP_062188.3	Gene:	Kcnn3 / 54263	RGDID:	2964	Length:	731	Species:	Rattus norvegicus

Alignment Length:	793	Identity:	379/793 - (47%)
Similarity:	483/793 - (60%)	Gaps:	118/793 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 HSHSSSPGS--------HPNLGTSSYQNL---ASSIPPSVPSRCRACRNCSRRASTTPTTLIDRS 242
            |.|.|..|.        .|:.|....|..   ..|.||:||.:             .|..|:.
  Rat     6 HFHDSGVGDLDEDPKCPCPSSGDEQQQQQQPPPPSAPPAVPQQ-------------PPGPLLQ-- 55

  Fly   243 ASRDSVKSAFQQGNLSGSMAICISNSALPQQQQLQQQYHLQQQQQQHYQLQQHHLHQ-QQLQQSQ 306
                                        ||..|||||...||||||..|.||..||. .||.|.|
  Rat    56 ----------------------------PQPPQLQQQQQQQQQQQQQQQQQQAPLHPLPQLAQLQ 92

  Fly   307 QQ-VPPVLITSSPT--------NGSRII----RQSSQ-----------PESSSTAICCGPHSACV 347
            .| |.|.|:.||||        |.:.|:    ||.||           |.|::|:   ||
  Rat    93 SQLVHPGLLHSSPTAFRAPNSANSTAILHPSSRQGSQLNLNDHLLGHSPSSTATS---GP----- 149

  Fly   348 GHAHSHSHTVPNVSLKQLRESSGDGIAGIAADSLRINGG-MRPFKQLRKPASTL------SIPGS 405
            |....|....|   |...|:|  :....||..|.:.:|| |:|..:|......|      ..|..
  Rat   150 GGGSRHRQASP---LVHRRDS--NPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAEPEGQPLQ 209

  Fly   406 MKTPSIANREQISSGCNEEAAEALVGIHSDYPRYMEERALTGGNTSRKPSTNSAKHKPNVGYRLG 470
            :.:||......|||..:..|.:.|  :|.....:..:.|.|...::..|..|..|:: |:||:||
  Rat   210 LFSPSNPPEIIISSREDNHAHQTL--LHHPNATHNHQHAGTTAGSTTFPKANKRKNQ-NIGYKLG 271

  Fly   471 KRKALFEKRKRISDYALVMGMFGIIVMVIENELSSAGVYTKASFYSTALKTLISVSTVILLGLIV 535
            .|:||||||||:|||||:.|||||:|||||.|| |.|:|:|.|.:|.|||.|||:||:||||||:
  Rat   272 HRRALFEKRKRLSDYALIFGMFGIVVMVIETEL-SWGLYSKDSMFSLALKCLISLSTIILLGLII 335

  Fly   536 AYHALEVQVRLFMIDNCADDWRIAMTWQRISQIGLELFICAIHPIPGEYYFQWTTKLANKNKTIG 600
            |||..|||  ||:|||.|||||||||::||..|.||:.:||||||||||.|.||.:|| .:.|..
  Rat   336 AYHTREVQ--LFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLA-FSYTPS 397

  Fly   601 TEMVPYDVALSLPMFLRLYLICRVMLLHSKLFTDASSRSIGALNRINFNTRFVLKTLMTICPGTV 665
            ......|:.||:|||||||||.||||||||||||||||||||||:||||||||:|||||||||||
  Rat   398 RAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTV 462

  Fly   666 LLVFMVSLWIIASWTLRQCERFHDEEH--ANLLNAMWLIAITFLSVGFGDIVPNTYCGRGIAVST 728
            ||||.:||||||:||:|.|||:||::.  :|.|.|||||:|||||:|:||:||:||||:|:.:.|
  Rat   463 LLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLT 527

  Fly   729 GIMGAGCTALLVAVVSRKLELTRAEKHVHNFMMDTQLTKRLKNAAANVLRETWLIYKHTRLVKRV 793
            ||||||||||:||||:||||||:|||||||||||||||||:||||||||||||||||||:|:|::
  Rat   528 GIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKI 592

  Fly   794 NPGRVRTHQRKFLLAIYALRKVKMDQRKLMDNANTITDMAKTQNTVYEIISDMSSRQDAIEERLT 858
            :..:||.||||||.||:.||.|||:||||.|.|||:.|::|.||.:|::|::::.|.:.:|:::.
  Rat   593 DHAKVRKHQRKFLQAIHQLRGVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIG 657

  Fly   859 NLEDKMQSIQEHMESLPDLLSRCLTQHQER-----IEQRRNFLHPDTAAVAPIQAPTPQSMFNAA 918
            :||.|::.:.....|||.|::..|.|.|::     :|.|     ..:.||....||...|....:
  Rat   658 SLESKLEHLTASFNSLPLLIADTLRQQQQQLLTAFVEAR-----GISVAVGTSHAPPSDSPIGIS 717

  Fly   919 PMLFPHSSVPSSN 931
            ...||.....||:
  Rat   718 STSFPTPYTSSSS 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SK	NP_001284887.1	SK_channel	472..582	CDD:281522	77/109 (71%)
		Ion_trans_2	669..748	CDD:285168	54/80 (68%)
		CaMBD	762..834	CDD:280961	51/71 (72%)
Kcnn3	NP_062188.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	102..161		18/69 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..259		3/18 (17%)
		SK_channel	273..380	CDD:397547	77/109 (71%)
		Ion_trans_2	468..547	CDD:400301	53/78 (68%)
		Calmodulin-binding. /evidence=ECO:0000250	561..637		53/75 (71%)
		CaMBD	561..636	CDD:198121	52/74 (70%)
		Prefoldin	<601..673	CDD:415586	31/71 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	703..731		7/28 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343268
Domainoid	1	1.000	168	1.000	Domainoid score	I3718
eggNOG	1	0.900	-	-		E1_KOG3684
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	614	1.000	Inparanoid score	I870
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265878at33208
OrthoFinder	1	1.000	-	-		FOG0001440
OrthoInspector	1	1.000	-	-		otm45389
orthoMCL	1	0.900	-	-		OOG6_102955
Panther	1	1.100	-	-	O	PTHR10153
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1159
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760