DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SK and Kcnn1

DIOPT Version :9

Sequence 1:	NP_001284887.1	Gene:	SK / 31456	FlyBaseID:	FBgn0029761	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	NP_062186.1	Gene:	Kcnn1 / 54261	RGDID:	2962	Length:	536	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	296/525 - (56%)
Similarity:	367/525 - (69%)	Gaps:	69/525 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   433 HSDYPRYMEERALTGGNTSRKPSTNSAKHKPNVGYRLGKRKALFEKRKRISDYALVMGMFGIIVM 497
            ||......||........|.||        |.|.:|||.|:||||||||:|||||:.|||||:||
  Rat    61 HSQAQEEEEEEEDEDRPGSGKP--------PTVSHRLGHRRALFEKRKRLSDYALIFGMFGIVVM 117

  Fly   498 VIENELSSAGVYTKASFYSTALKTLISVSTVILLGLIVAYHALEVQVRLFMIDNCADDWRIAMTW 562
            |.|.|| |.|||||.|..|.|||.|||:||||||||::.|||.|:|  ||::||.||||||||||
  Rat   118 VTETEL-SWGVYTKESLCSFALKCLISLSTVILLGLVILYHAREIQ--LFLVDNGADDWRIAMTW 179

  Fly   563 QRISQIGLELFICAIHPIPGEYYFQWTTKLANKNKTIGTEMVP------YDVALSLPMFLRLYLI 621
            :|:|.|.|||.:|||||:||.|.|.||.:||       ..:||      .||.||:||||||||:
  Rat   180 ERVSLISLELAVCAIHPVPGHYRFTWTARLA-------FSLVPSAAEADVDVLLSIPMFLRLYLL 237

  Fly   622 CRVMLLHSKLFTDASSRSIGALNRINFNTRFVLKTLMTICPGTVLLVFMVSLWIIASWTLRQCER 686
            .|||||||::||||||||||||||:.||||||.|||||||||||||||.:|.||:|:||:|.|||
  Rat   238 ARVMLLHSRIFTDASSRSIGALNRVTFNTRFVTKTLMTICPGTVLLVFSISSWIVAAWTVRVCER 302

  Fly   687 FHDEEH--ANLLNAMWLIAITFLSVGFGDIVPNTYCGRGIAVSTGIMGAGCTALLVAVVSRKLEL 749
            :||::.  :|.|.|||||:|||||:|:||:||:||||:|:.:.|||||||||||:||||:|||||
  Rat   303 YHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLEL 367

  Fly   750 TRAEKHVHNFMMDTQLTKRLKNAAANVLRETWLIYKHTRLVKRVNPGRVRTHQRKFLLAIY---A 811
            |:|||||||||||||||||:||||||||||||||||||||||:.:..|||.||||||.||:   .
  Rat   368 TKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQSRVRKHQRKFLQAIHQAQK 432

  Fly   812 LRKVKMDQRKLMDNANTITDMAKTQNTVYEIISDMSSRQDAIEERLTNLEDKMQSIQEHMESLPD 876
            ||.||::|.|:.|.|||:.|:||.|:..||::|::.::|:.:|.||..||.::..:...:::||.
  Rat   433 LRTVKIEQGKVNDQANTLADLAKAQSIAYEVVSELQAQQEELEARLAALESRLDVLGASLQALPS 497

  Fly   877 LLSRCLTQHQERIEQRRNFLHPDTAAVAPIQAPTPQSMFNAAPMLFPHSSVPSSNNAAA---TYH 938
            |:::                     |:.|:..|.|.               ||....||   ..|
  Rat   498 LIAQ---------------------AICPLPPPWPG---------------PSHLTTAAQSPQSH 526

  Fly   939 W-PTS 942
            | ||:
  Rat   527 WLPTT 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SK	NP_001284887.1	SK_channel	472..582	CDD:281522	77/109 (71%)
		Ion_trans_2	669..748	CDD:285168	52/80 (65%)
		CaMBD	762..834	CDD:280961	51/74 (69%)
Kcnn1	NP_062186.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..90		10/36 (28%)
		SK_channel	92..199	CDD:397547	77/109 (71%)
		Ion_trans_2	287..366	CDD:400301	51/78 (65%)
		Calmodulin-binding. /evidence=ECO:0000250	380..459		54/78 (69%)
		CaMBD	380..458	CDD:198121	53/77 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..536		7/18 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343264
Domainoid	1	1.000	168	1.000	Domainoid score	I3718
eggNOG	1	0.900	-	-		E1_KOG3684
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	614	1.000	Inparanoid score	I870
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265878at33208
OrthoFinder	1	1.000	-	-		FOG0001440
OrthoInspector	1	1.000	-	-		otm45389
orthoMCL	1	0.900	-	-		OOG6_102955
Panther	1	1.100	-	-	O	PTHR10153
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.800