Protein Alignment SK and KCNN4

DIOPT Version :9

• Sequence 1: NP_001284887.1
• Gene: SK / 31456
• FlyBaseID: FBgn0029761
• Length: 1174
• Species: Drosophila melanogaster
• Sequence 2: NP_002241.1
• Gene: KCNN4 / 3783
• HGNCID: 6293
• Length: 427
• Species: Homo sapiens
• Alignment Length: 455
• Identity: 186/455 - (40%)
• Similarity: 259/455 - (56%)
• Gaps: 56/455 - (12%)

  Fly   469 LGKRKALFEKRKRISDYALVMGMFGIIVMVIENELSSAGVYTKASFYSTALKTLISVSTVILLGL 533
            |.:||.|.|:.|.::.:|||:...||.:||:..|:...|..:.| .|...:|..||:||.:||.|
Human    12 LRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWA-LYLFLVKCTISISTFLLLCL 75

  Fly   534 IVAYHALEVQVRLFMIDNCADDWRIAMTWQRISQIGLELFICAIHPIP--GEYYFQWTTKLANKN 596
            |||:||.|||  |||.||...|||:|:|.::.:||.|||.:|.:||.|  |....|
Human    76 IVAFHAKEVQ--LFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPAPVRGPPCVQ--------- 129

  Fly   597 KTIG---TEMVPY-------DVALSLPMFLRLYLICRVMLLHSKLFTDASSRSIGALNRINFNTR 651
             .:|   |...|:       :..|||.|.|||||:.|.:||.|.:..:||.|||||||::.|...
Human   130 -DLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHW 193

  Fly   652 FVLKTLMTICPGTVLLVFMVSLWIIASWTLRQCERFHDEEHANLLNAMWLIAITFLSVGFGDIVP 716
            ||.|..|...||.:||...:.||:..:|.|...||.......:|.:.:|||.||||::|:||:||
Human   194 FVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVP 258

  Fly   717 NTYCGRGIAVSTGIMGAGCTALLVAVVSRKLELTRAEKHVHNFMMDTQLTKRLKNAAANVLRETW 781
            .|..|:.:.:.||:||..|||||||||:||||..:|||||||||||.|.||.:|.:||.||:|.|
Human   259 GTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAW 323

  Fly   782 LIYKHTRLVKRVNPGRVRTHQRKFLLAIYALRKVKMDQRKLMDNANTITDMAKTQNTVYEIISDM 846
            :.|||||   |......|.||||.|.||.|.|:|::..|||.:..|::.|::|....:|::..::
Human   324 MFYKHTR---RKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNL 385

  Fly   847 SSRQDAIEERLTNLEDKMQSIQEHMESLPDLLSRCLTQHQERIEQRRNFLHPDTAAVAPIQAPTP 911
            ||...|:|:::..|..|       :::|.:|||                     .|:.|.|.|.|
Human   386 SSSHRALEKQIDTLAGK-------LDALTELLS---------------------TALGPRQLPEP 422

  Fly   912  911
            Human   423  422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SK	NP_001284887.1	SK_channel	472..582	CDD:281522	51/111 (46%)
		Ion_trans_2	669..748	CDD:285168	36/78 (46%)
		CaMBD	762..834	CDD:280961	33/71 (46%)
KCNN4	NP_002241.1	SK_channel	15..122	CDD:397547	50/109 (46%)
		Ion_trans_2	<237..290	CDD:400301	30/52 (58%)
		Calmodulin-binding	286..347		37/63 (59%)
		CaMBD	304..376	CDD:198121	34/74 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149388
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265878at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10153
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950