Protein Alignment SK and KCNN2

DIOPT Version :10

• Sequence 1: NP_001284887.1
• Gene: SK / 31456
• FlyBaseID: FBgn0029761
• Length: 1174
• Species: Drosophila melanogaster
• Sequence 2: XP_054208537.1
• Gene: KCNN2 / 3781
• HGNCID: 6291
• Length: 858
• Species: Homo sapiens
• Alignment Length: 891
• Identity: 383/891 - (42%)
• Similarity: 498/891 - (55%)
• Gaps: 177/891 - (19%)

  Fly   141 PDIEVHEEDQ-----EQ----------HSQQLNATTMATMTNNQQQQQPTISIMNLSLKPGDSHS 190
            ||:|...:.|     ||          |.||            |||.|.         ||....:
Human    65 PDMETPLQFQRGFFPEQPPPPPRSSHLHCQQ------------QQQSQD---------KPCPPFA 108

  Fly   191 HSSSPGSHPNLGTSSYQNLASSIPPSVPSRCRACRNCSRRASTTPT-------TLIDRSASRDSV 248
            ....|..||:|   ::|..||    ...|.|..|.:|:  :|..|.       :|:.|::|....
Human   109 PLPHPHHHPHL---AHQQPAS----GGSSPCLRCNSCA--SSGAPAAGAGDNLSLLLRTSSPGGA 164

  Fly   249 KSAFQQGNLSGSMAICISNSALPQQQ-------------QLQQQYHLQQQQQQHYQLQQHHLHQQ 300
            ........||||...|...|:....|             .|:|||..|..||.....|.|..|.
Human   165 FRTRTSSPLSGSSCCCCCCSSRRGSQLNVSELTPSSHASALRQQYAQQSAQQSASASQYHQCHS- 228

  Fly   301 QLQQSQQQVPPVLITSSPTNGSRIIRQSSQPESSSTAICCGPHSACVGHAHSHSHTVPNVSLKQL 365
                                    ::.::.|..|..::..||.   :.|.|.|.|...:...:..
Human   229 ------------------------LQPAASPTGSLGSLGSGPP---LSHHHHHPHPAHHQHHQPQ 266

  Fly   366 RESSGDGIAGIAADSLRINGG-MRPFKQLR----------------KPASTLSIPGSMKTPSIAN 413
            .....:....||..|.|.||| |||...|.                :|.:::...|...:||.|
Human   267 ARRESNPFTEIAMSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAA- 330

  Fly   414 REQISSGCNEEAAEALVGIHSDYPRYMEER---------ALTG----------------GNTSRK 453
                       ||.|...:.|..|..:..:         ||.|                |:.|..
Human   331 -----------AAAAAAAVSSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSS 384

  Fly   454 PSTNSAKHKPNVGYRLGKRKALFEKRKRISDYALVMGMFGIIVMVIENELSSAGVYTKASFYSTA 518
            .:.:|.|...|:||:||.|:||||||||:|||||:.|||||:|||||.|| |.|.|.|||.||.|
Human   385 GTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETEL-SWGAYDKASLYSLA 448

  Fly   519 LKTLISVSTVILLGLIVAYHALEVQVRLFMIDNCADDWRIAMTWQRISQIGLELFICAIHPIPGE 583
            ||.|||:||:||||||:.|||.|:|  |||:||.|||||||||::||..|.||:.:||||||||.
Human   449 LKCLISLSTIILLGLIIVYHAREIQ--LFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGN 511

  Fly   584 YYFQWTTKLANKNKTIGTEMVPYDVALSLPMFLRLYLICRVMLLHSKLFTDASSRSIGALNRINF 648
            |.|.||.:|| .:....|.....|:.||:|||||||||.||||||||||||||||||||||:|||
Human   512 YTFTWTARLA-FSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINF 575

  Fly   649 NTRFVLKTLMTICPGTVLLVFMVSLWIIASWTLRQCERFHDEEH--ANLLNAMWLIAITFLSVGF 711
            |||||:|||||||||||||||.:||||||:||:|.|||:||::.  :|.|.|||||:|||||:|:
Human   576 NTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGY 640

  Fly   712 GDIVPNTYCGRGIAVSTGIMGAGCTALLVAVVSRKLELTRAEKHVHNFMMDTQLTKRLKNAAANV 776
            ||:|||||||:|:.:.|||||||||||:||||:||||||:|||||||||||||||||:|||||||
Human   641 GDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANV 705

  Fly   777 LRETWLIYKHTRLVKRVNPGRVRTHQRKFLLAIYALRKVKMDQRKLMDNANTITDMAKTQNTVYE 841
            |||||||||:|:|||:::..:||.||||||.||:.||.|||:||||.|.|||:.|:|||||.:|:
Human   706 LRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYD 770

  Fly   842 IISDMSSRQDAIEERLTNLEDKMQSIQEHMESLPDLLSRCLTQHQERIEQRRNFLHPDTAAVAPI 906
            :|||::.|.:..|:|:..||.|::::...:.:||.|:|:.:.|      |:|:|:.      |.:
Human   771 MISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQ------QQRDFIE------AQM 823

  Fly   907 QAPTPQSMFNAAPMLFPHSSVPSSNNAAATYHWPTSPILPPISSRT 952
            ::......:||            ..:.:::....:|...||.||.:
Human   824 ESYDKHVTYNA------------ERSRSSSRRRRSSSTAPPTSSES 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SK	NP_001284887.1	SK_channel	469..581	CDD:460958	79/111 (71%)
		Ion_trans_2	669..748	CDD:462301	55/80 (69%)
		CaMBD	762..836	CDD:460739	53/73 (73%)
KCNN2	XP_054208537.1	SK_channel	400..509	CDD:460958	79/111 (71%)
		Ion_trans_2	598..677	CDD:462301	54/78 (69%)
		CaMBD	691..766	CDD:198121	54/74 (73%)