Protein Alignment SK and kcnl-3

DIOPT Version :9

• Sequence 1: NP_001284887.1
• Gene: SK / 31456
• FlyBaseID: FBgn0029761
• Length: 1174
• Species: Drosophila melanogaster
• Sequence 2: NP_001367414.1
• Gene: kcnl-3 / 182164
• WormBaseID: WBGene00015387
• Length: 692
• Species: Caenorhabditis elegans
• Alignment Length: 628
• Identity: 198/628 - (31%)
• Similarity: 312/628 - (49%)
• Gaps: 119/628 - (18%)

  Fly   341 GPHSACVGHAHSHSHTVPNVSLKQ----------------LRESSGDGIAGIAADSLRINGGMRP 389
            ||..|.........:..|..|...                |..|..:.:..::||.||:||..:.
 Worm    73 GPTIASAPSVEQEDYRTPRPSFDSNGYVGKSFDFSSAQHGLTASESNALVKVSADFLRLNGSRQQ 137

  Fly   390 FKQL---RK--------------------------------PASTLSIPGSMK-----TPSIANR 414
            ||.|   ||                                |..|:...||..     .||: |:
 Worm   138 FKNLLSARKKLGSLPPAYTRIDYSRESLDSHSARGIPNHHGPVITVEDTGSQLRINNIKPSV-NQ 201

  Fly   415 EQISSGCNEEAAEALVGIHSDYPRYMEERALTGGNTSRKPSTNSAKHKPNVG-------YRLGKR 472
            ..:.|.|:.|  :.:|      .:.....::|..|||.....|::::...:.       ||:  |
 Worm   202 HLLESSCSFE--KTMV------TQCESNGSVTSHNTSSAFQRNNSRYGVPIDSTAVKQVYRV--R 256

  Fly   473 KALFEKRKRISDYALVMGMFGIIVMVIENELSSAGVY--TKASFYSTALKTLISVSTVILLGLIV 535
            ......|.||:|.:|.:.:||:|:|::|:|:::...|  :|..:.|.:|:..::.||:.||..|:
 Worm   257 SERLTNRVRITDRSLYLALFGVILMLVESEITAEKFYGVSKTHWISQSLRVGVTCSTIALLYHII 321

  Fly   536 AYHALEVQVRLFMIDNCADDWRIAMTWQRISQIGLELFICAIHPIPGEYYFQWT-------TKLA 593
            .||..::.:.|  :|..|||||:.:|.:|:.|..:|...|.|.|:||....:||       ....
 Worm   322 LYHLNDIVLEL--VDCGADDWRVVVTTERVIQFCIEFICCGICPLPGSGEMKWTFIEPSLHKDGP 384

  Fly   594 NKNKTIGTEM--VPYDVALSLPMFLRLYLICRVMLLHSKLFTDASSRSIGALNRINFNTRFVLKT 656
            ::.:|:.|..  ||.||.||..|..|.||..|.|:||||.|.|||:|::.|||||..|..||:||
 Worm   385 SEERTVQTRNVDVPVDVILSCFMLCRSYLFARFMVLHSKQFQDASTRTLAALNRIQVNFSFVIKT 449

  Fly   657 LMTICPGTVLLVFMVSLWIIASWTLRQCER--FHDEEHANLL--NAMWLIAITFLSVGFGDIVPN 717
            .:...|...|..|....|||.||...||||  |..:...::|  |::|.|||||:..|:|||||.
 Worm   450 SLDQQPVLFLTTFTFIFWIIMSWMFVQCERYGFSGKNPQSILYSNSLWFIAITFMLNGYGDIVPQ 514

  Fly   718 TYCGRGIAVSTGIMGAGCTALLVAVVSRKLELTRAEKHVHNFMMDTQLTKRLKNAAANVLRETWL 782
            |..||.||:..|::||..:::|:||:||.:.|::.:::|:|||.|::|.:..|.|||.||:.||.
 Worm   515 TNAGRFIAIFVGVVGAVISSILIAVISRNILLSQGQRNVNNFMYDSKLAREHKEAAARVLQHTWH 579

  Fly   783 IYKHTRLVKRVNPG--RVRTHQRKFLLAIYALRKVKMDQRKLMDNANTITDMAKTQNT--VYEII 843
            |:|   .::..:.|  |:||:|||||.||:..|.||.:.|:..:|        .:||.  :..::
 Worm   580 IHK---CLQGSDGGNRRLRTYQRKFLKAIHKFRSVKSEMREFSEN--------NSQNNPQMTRLV 633

  Fly   844 SDMSSRQDAIEERLTNLEDKM--------QSIQEH-MESLPDL 877
            :||.:..    :||.|::|:|        ||::.| |.|.|::
 Worm   634 TDMHTSM----QRLLNVQDEMRMQIEVLQQSVRNHYMHSTPNV 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SK	NP_001284887.1	SK_channel	472..582	CDD:281522	37/111 (33%)
		Ion_trans_2	669..748	CDD:285168	38/82 (46%)
		CaMBD	762..834	CDD:280961	28/73 (38%)
kcnl-3	NP_001367414.1	SK_channel	256..366	CDD:397547	37/111 (33%)
		Ion_trans_2	462..542	CDD:400301	36/79 (46%)
		CaMBD	559..632	CDD:198121	30/83 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160749
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3684
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3712
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265878at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102955
Panther	1	1.100	-	-	O	PTHR10153
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.660