DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SK and kcnl-2

DIOPT Version :9

Sequence 1:	NP_001284887.1	Gene:	SK / 31456	FlyBaseID:	FBgn0029761	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	NP_001293204.1	Gene:	kcnl-2 / 172602	WormBaseID:	WBGene00008570	Length:	855	Species:	Caenorhabditis elegans

Alignment Length:	975	Identity:	325/975 - (33%)
Similarity:	466/975 - (47%)	Gaps:	242/975 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 QVKSNSTNGPTTGASTSSSGSV-----SGGGGG-------SGSGGGS--------------ASGS 80
            |::.|.:      .::||:|.|     :.||.|       ||..|..              ::.|
Worm    11 QIQRNES------VTSSSAGDVNEIPKTNGGPGHPIVRRKSGMMGKKFPSLQVSHYPVLLLSNSS 69

  Fly    81 AAGASKP----TLMRQDRTSTYLTSPQQSQHARMGSEESM---RGGASGAAGHDEDVEQGLV--R 136
            |..::.|    |.....:|.|..|.|:.       .|||:   |..:||       ::|..|  |
Worm    70 ADNSTNPHPSVTWKTSQQTDTEPTRPEI-------LEESLPKVRKSSSG-------LKQSSVSAR 120

  Fly   137 SSIVPDIEVHEEDQEQHSQQLNATTMATMTNNQQQQQPTISIMNLSLKP----GDSHSHSSSPGS 197
            :|:        :.:|:......:||.:|::       ||      |.||    |.|.|.|....:
Worm   121 NSL--------DFRERPRFVRTSTTTSTLS-------PT------SEKPPMPLGQSCSSSGRLHA 164

  Fly   198 HPNLGTSSYQNLASSIPPSVPSRCRACRNCSRRASTTPTTLIDRSASRDSVKSAFQQGNLSG-SM 261
            .|.:..||.                                         |:...:...|.| ..
Worm   165 SPKISFSSV-----------------------------------------VQQTMKWNELGGMGS 188

  Fly   262 AICISNSALPQQQQLQQQYHLQQQQQQHYQLQQHHLHQQQLQQSQQQVPPVLITSSPTNGSRIIR 326
            ..|:| ||.|..         ..::||.:....||....:...|.:.    |..|.....:...:
Worm   189 GRCLS-SASPIS---------AAERQQLWGSSMHHSFDDRPSASSED----LFASCNDIDNAYRQ 239

  Fly   327 QSSQPESSSTAICCGPHS-----ACVG------HAHSHSHTVPNVSLKQLRES--SGDGIAGIAA 378
            |..:....|.|...|.|.     ||.|      ...|:....|.:..:..:.|  |...:|.|:.
Worm   240 QRKRRAGISGAATGGSHQRDGPFACAGGNGYSSAGFSNGRGFPPLGGRSPQSSFDSNQDVAQISM 304

  Fly   379 DSLRING---GMRPF--------------------------KQLRKPASTLSIPG---------- 404
            :.:|:||   .:|||                          ...|..|:..||.|
Worm   305 NWMRMNGLGPSLRPFLNSGNHTPKKTVIHNSQSTNHISRIGSLRRMHAADASIDGKLSLSGTQGE 369

  Fly   405 --SMKTPSIANREQISSGCNEEAAEALVGIHSDYPRYMEERALTGGNTSRKPSTNSAKHKPNVGY 467
              |.|:.|||....:.:|.....|   :|..|..| .|:|:                  ..|.|.
Worm   370 TASRKSVSIAYSNDLEAGGKGNGA---IGDDSTVP-LMDEK------------------DDNSGG 412

  Fly   468 RLGKRKALFEKRKRISDYALVMGMFGIIVMVIENELSSAGVYTKASFYSTALKTLISVSTVILLG 532
            ||.:|:.|.|||:.:||.||...:.|||:|:|||||.:|.|....|..|..||..|..:|..||.
Worm   413 RLIRREILHEKRRHVSDRALAFAIMGIILMIIENELRTAYVIRPGSSLSHLLKFFIIFTTTALLS 477

  Fly   533 LIVAYHALEVQVRLFMIDNCADDWRIAMTWQRISQIGLELFICAIHPIPGEYYFQWTTKLANKNK 597
            .:..:|.:|:|  |||..|.||||.:|::::|..||||||.||.:.|:|.|:...:.....: :|
Worm   478 FVGYFHVIEIQ--LFMNANAADDWMVALSFRRTCQIGLELLICMLCPLPIEFIAPFMNDRFH-DK 539

  Fly   598 TIGTEMVPYDVALSLPMFLRLYLICRVMLLHSKLFTDASSRSIGALNRINFNTRFVLKTLMTICP 662
            |    :...:|.||:.||.|||.:||||||||::|||||||||..|||:|||.||:|||||||||
Worm   540 T----LYAVNVFLSIMMFFRLYWLCRVMLLHSRVFTDASSRSIAGLNRVNFNARFILKTLMTICP 600

  Fly   663 GTVLLVFMVSLWIIASWTLRQCER-------FHDEEHANLLNAMWLIAITFLSVGFGDIVPNTYC 720
            ||:|::|...|||||.|.||.|||       ::|   .|.:|::||:||||||||:|||||.|.|
Worm   601 GTMLMIFTAFLWIIAGWILRLCEREYMTPDKYND---INYVNSIWLVAITFLSVGYGDIVPKTNC 662

  Fly   721 GRGIAVSTGIMGAGCTALLVAVVSRKLELTRAEKHVHNFMMDTQLTKRLKNAAANVLRETWLIYK 785
            ||.:|:.|||:|...::::|||::||||||||||||||||.||||||:||::|||||||||.|:|
Worm   663 GRSMAIVTGILGTCASSMVVAVIARKLELTRAEKHVHNFMQDTQLTKQLKHSAANVLRETWFIFK 727

  Fly   786 HTRLVKRVNPGRVRTHQRKFLLAIYALRKVKMDQRKLMDNANTITDMAKTQNTVYEIISDMSSRQ 850
            ..:||::.:.|::|.||||||||||.:|:|:.|||||.:|..::.|:|||.:..||::.|:.|.|
Worm   728 FRKLVEKPDFGKIRKHQRKFLLAIYEMRRVRRDQRKLAENLVSLGDVAKTSSNTYELVHDVHSTQ 792

  Fly   851 DAIEERLTNLEDKMQSIQEHMESLPDLLSRCLTQHQERIEQRRNFLHPDTAAVAPIQA-PTPQSM 914
            :.:..|:|.:|.::..|...:.||.:||       :...|||:.     :..:....| ||||.:
Worm   793 EGLSLRITAIEHQLSDISRELSSLAELL-------RGSNEQRKK-----SVVIGGESAPPTPQQI 845

Fly 915 914
Worm 846 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SK	NP_001284887.1	SK_channel	472..582	CDD:281522	50/109 (46%)
		Ion_trans_2	669..748	CDD:285168	44/85 (52%)
		CaMBD	762..834	CDD:280961	42/71 (59%)
kcnl-2	NP_001293204.1	SK_channel	417..525	CDD:367547	50/109 (46%)
		Ion_trans_2	608..690	CDD:369572	43/84 (51%)
		CaMBD	704..779	CDD:198121	45/74 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160748
Domainoid	1	1.000	105	1.000	Domainoid score	I4184
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H135651
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265878at33208
OrthoFinder	1	1.000	-	-		FOG0001440
OrthoInspector	1	1.000	-	-		oto19527
orthoMCL	1	0.900	-	-		OOG6_102955
Panther	1	1.100	-	-	LDO	PTHR10153
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4617
SonicParanoid	1	1.000	-	-		X1159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880