DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SK and kcnn2

DIOPT Version :9

Sequence 1:	NP_001284887.1	Gene:	SK / 31456	FlyBaseID:	FBgn0029761	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	XP_012811747.1	Gene:	kcnn2 / 100145581	XenbaseID:	XB-GENE-6077411	Length:	743	Species:	Xenopus tropicalis

Alignment Length:	736	Identity:	366/736 - (49%)
Similarity:	471/736 - (63%)	Gaps:	83/736 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 IPPSVPSRCRACRNCSRRASTTPTTLIDRSASRDSVKSAFQQGNLSGSMAICISNSA-LPQQQQL 276
            :.|:..:||..    |..|...|::.::..|    :.|:.....||.....|..||: :....|.
Frog     6 VRPTNRTRCLD----STGAEMAPSSRVEGFA----IPSSAHCAGLSAWQDSCSFNSSDMDTSLQF 62

  Fly   277 QQQYHLQQQQQQHYQLQQHHLH-----QQQLQQS------------QQQVPPVLITSSPTNGSRI 324
            |:.:   ..:|||...:..|||     :|.|.|:            |....|:|.||||..|:
Frog    63 QRGF---SPEQQHSLPRPQHLHCQSPDEQLLYQADGPCVQCNSCSFQGDNLPLLRTSSPIIGA-- 122

  Fly   325 IRQSSQPESSSTA----------ICCGPHSACVGH------------AHSHSHTVPNVSLKQLRE 367
            .|..|.|.||.::          :....|::...|            .||.....|:.|  |.||
Frog   123 FRTGSSPLSSGSSRQGSQLNVSELTPSSHASSSRHPQYQSQYHQYHQCHSRQQASPSSS--QRRE 185

  Fly   368 SSGDGIAGIAADSLRINGG-MRPFKQLRKPASTLSIPGSMKTPSIANREQISSGCNEEAAEALV- 430
            |  :....||..|.|.||| |||...|......|....|...|    .:.:||.  ..|.|.:|
Frog   186 S--NPFTEIAMSSCRYNGGVMRPLSNLSASRRNLHELDSESQP----LQPVSSA--SAAPEIVVS 242

  Fly   431 ----GIHSDYPRYMEERALTGGNTSRKPSTNSAKHKPNVGYRLGKRKALFEKRKRISDYALVMGM 491
                ..:|..|....||  .||..:....:...|:: |:||:||.|:||||||||:|||||:.||
Frog   243 KPEHNSNSLAPYGSGER--PGGQQNNGAKSGKKKNQ-NIGYKLGHRRALFEKRKRLSDYALIFGM 304

  Fly   492 FGIIVMVIENELSSAGVYTKASFYSTALKTLISVSTVILLGLIVAYHALEVQVRLFMIDNCADDW 556
            |||:|||||.|| |.|.|.|.|.||.|||.|||:||:||||||:.|||.|:|  |||:||.||||
Frog   305 FGIVVMVIETEL-SWGAYDKGSLYSLALKCLISLSTIILLGLIIVYHAREIQ--LFMVDNGADDW 366

  Fly   557 RIAMTWQRISQIGLELFICAIHPIPGEYYFQWTTKLANKNKTIGTEMVPYDVALSLPMFLRLYLI 621
            |||||::||..|.||:.:||||||||.|.|.||.:|| .:.|..|.....|:.||:|||||||||
Frog   367 RIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLA-FSYTPSTTTADVDIILSIPMFLRLYLI 430

  Fly   622 CRVMLLHSKLFTDASSRSIGALNRINFNTRFVLKTLMTICPGTVLLVFMVSLWIIASWTLRQCER 686
            .||||||||||||||||||||||:||||||||:|||||||||||||||.:||||||:||:|.|||
Frog   431 ARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACER 495

  Fly   687 FHDEEH--ANLLNAMWLIAITFLSVGFGDIVPNTYCGRGIAVSTGIMGAGCTALLVAVVSRKLEL 749
            :||::.  :|.|.|||||:|||||:|:||:|||||||:|:.:.|||||||||||:||||:|||||
Frog   496 YHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLEL 560

  Fly   750 TRAEKHVHNFMMDTQLTKRLKNAAANVLRETWLIYKHTRLVKRVNPGRVRTHQRKFLLAIY---A 811
            |:|||||||||||||||||:||||||||||||||||:|:|||:::..|||.||||||.||:   .
Frog   561 TKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHARVRKHQRKFLQAIHQARK 625

  Fly   812 LRKVKMDQRKLMDNANTITDMAKTQNTVYEIISDMSSRQDAIEERLTNLEDKMQSIQEHMESLPD 876
            ||.|||:||||.|.|||:.|:|||||.:|::|||::.|.:..|:|:..||.|::::...:::||.
Frog   626 LRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVVLETKLETLIGSIQALPG 690

  Fly   877 LLSRCLTQHQ-ERIE-QRRNF 895
            |:|:.::|.| :.:| |.:|:
Frog   691 LISQTISQQQRDLVEVQLQNY 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SK	NP_001284887.1	SK_channel	472..582	CDD:281522	77/109 (71%)
		Ion_trans_2	669..748	CDD:285168	55/80 (69%)
		CaMBD	762..834	CDD:280961	52/74 (70%)
kcnn2	XP_012811747.1	SK_channel	285..392	CDD:281522	77/109 (71%)
		Ion_trans_2	480..559	CDD:285168	54/78 (69%)
		CaMBD	573..648	CDD:280961	52/74 (70%)
		Prefoldin	610..688	CDD:298833	38/77 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	164	1.000	Domainoid score	I3893
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	601	1.000	Inparanoid score	I938
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265878at33208
OrthoFinder	1	1.000	-	-		FOG0001440
OrthoInspector	1	1.000	-	-		otm48468
Panther	1	1.100	-	-	LDO	PTHR10153
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160