Protein Alignment XRCC1 and xrcc1

DIOPT Version :10

• Sequence 1: NP_572217.1
• Gene: XRCC1 / 31451
• FlyBaseID: FBgn0026751
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_001003988.3
• Gene: xrcc1 / 445480
• ZFINID: ZDB-GENE-040822-30
• Length: 618
• Species: Danio rerio
• Alignment Length: 639
• Identity: 207/639 - (32%)
• Similarity: 299/639 - (46%)
• Gaps: 142/639 - (22%)

  Fly     1 MPIALFKSVREVSSEDAVHVAANLLKENAGKKWRTKAPGEKSAYVVLEFEEPQQITGIDIGNEHA 65
            ||....|.|...||||..|.|.|||..:..:||:...||||...|:|:.|:.:||..||||||.:
Zfish     1 MPELKLKHVVSCSSEDNTHKADNLLSSDTYRKWKAARPGEKQVSVILQLEKEEQIHSIDIGNEGS 65

  Fly    66 AFIEVLVSR-TGCQADDFRELLLSSSFMTPIESKNSSNPNRVRCFSSTSLAESALPEKWKLLQIV 129
            |||||||.. |..:..||..||::||||:|.||:|.:|.||||.|....|.::...|||..::||
Zfish    66 AFIEVLVGHSTSVKDQDFEVLLVTSSFMSPTESRNGTNTNRVRFFGPGQLVKAQSQEKWDRVKIV 130

  Fly   130 CTQPFNRHVPYGLSFVKVH-------VVAAAAPKVKSLVPQGVMQFGTFKLREESPDSETDNQ-- 185
            |:||:::.:.||:||:|:|       ...:..||:..|        |.|::::|||.:.::.|
Zfish   131 CSQPYSKTIAYGISFIKLHSPPDGNEAPVSTPPKLTKL--------GQFRVKDESPSAGSNVQPG 187

  Fly   186 ---VNRFHSWKKQTQHK-SPAISATS-TAAAIRDAGSTALRRLSAGKVSSLAASPKTSTSPSPVL 245
               .:|..|.|..|..| ||.....| .|||::..||:             ..:|.:.|..:||
Zfish   188 ALFFSRDTSAKSSTGLKVSPPNERLSYAAAALKTEGSS-------------THTPASDTQQAPV- 238

  Fly   246 NALRSVSPTPLDAKPLDRNRASLLFGDDDEDVKDAEVNAKKQRLSKHLEADKDRRRLEQEKERES 310
                                                                 :|:.|..|||
Zfish   239 -----------------------------------------------------KRKFEFSKER-- 248

  Fly   311 RKKKSSRHSLDKSISKEDKPPAKEHNSSSREKSTAKEEKEQLRKEERSHSKEEKSRRKEKSKHDH 375
                     |:.|     .||||:.:||:..::|.|       .:.||......|.|...::...
Zfish   249 ---------LEAS-----GPPAKKPSSSASAETTPK-------AKARSSMGTSPSSRASPAQKSS 292

  Fly   376 RSSDTSNSKESSRPTAQKRHSSPTAVAVTPAKKQKIVDTAIQYRPLNQLLKGVVLVISGIQNPDR 440
            ...::..:|..|:|..:.:..|..:|                  |.|::|:|||.|:||.|||.|
Zfish   293 DKRESPKTKPESKPKPKPKPKSSESV------------------PFNRILEGVVFVLSGFQNPFR 339

  Fly   441 ADLRSKAVALGAKYKADWGSGCTHLICAFKNTPKYNQVKGKGKIVTR-SWIEKCYELKKYLPWRR 504
            ||||.||:||||:|:.||....|||||||.|||||:|||..|.|:.| .|:..|::.|:.:..:|
Zfish   340 ADLRDKALALGARYRPDWTPDATHLICAFANTPKYSQVKAAGGIIVRKEWVMDCHKNKQKISCKR 404

  Fly   505 YALD------TNDIGQPESDEELCDEAT---RPRRDSSKDDVAMLEDSKLTALADQNDVEMNPDA 560
            |.:|      .::..|.||::|.....|   :|.....:..|...|:.:........|.|...|.
Zfish   405 YLMDGAESSSESEAEQDESEDETPKVKTPEKKPVTPKKQQPVEEEEEEEEEEYGGSTDEEGPGDD 469

  Fly   561 LSGIDTEDELQRVAEENKTKKAKLRTTVKTKSQDIYEVSTDEE-DYLELKKKQI 613
            .||:||||||.||...::.|||..::..|.|::|.|..||||. |..|.:.|.|
Zfish   470 GSGMDTEDELNRVEMASRKKKAAEQSADKGKNEDPYGGSTDENTDAEEEEDKPI 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XRCC1	NP_572217.1	XRCC1_N	1..144	CDD:460356	67/143 (47%)
		U2AF_lg	285..>379	CDD:273727	19/93 (20%)
		BRCT_XRCC1_rpt1	427..505	CDD:349357	44/78 (56%)
xrcc1	NP_001003988.3	None