DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment XRCC1 and Xrcc1

DIOPT Version :9

Sequence 1:	NP_572217.1	Gene:	XRCC1 / 31451	FlyBaseID:	FBgn0026751	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_033558.3	Gene:	Xrcc1 / 22594	MGIID:	99137	Length:	631	Species:	Mus musculus

Alignment Length:	657	Identity:	203/657 - (30%)
Similarity:	295/657 - (44%)	Gaps:	192/657 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPIALFKSVREVSSEDAVHVAANLLKENAGKKWRTKAPGEKSAYVVLEFEEPQQITGIDIGNEHA 65
            ||....:.|...||:|:.|.|.||||.:..:|||....|||:..|||:.|:.:||..:||||:.:
Mouse     1 MPEISLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTISVVLQLEKEEQIHSVDIGNDGS 65

  Fly    66 AFIEVLV--SRTGCQA--DDFRELLLSSSFMTPIESKNSSNPNRVRCFSSTSLAESALPEKWKLL 126
            ||:||||  |..|..|  .|:..||::||||:|.||::.|||||||.|....|..:|..::|..:
Mouse    66 AFVEVLVGSSAGGATAGEQDYEVLLVTSSFMSPSESRSGSNPNRVRIFGPDKLVRAAAEKRWDRV 130

  Fly   127 QIVCTQPFNRHVPYGLSFVKVH------VVAAAAPKVKSLVPQGVMQFGTFKLREESPDSETDNQ 185
            :|||:||:::..||||||||.|      ...|.:.||.      |.:.|.|:::||...:.:...
Mouse   131 KIVCSQPYSKDSPYGLSFVKFHSPPDKDEAEATSQKVT------VTKLGQFRVKEEDDSANSLKP 189

  Fly   186 VNRFHSWKKQTQHKSPAISATSTAAAIRDAGSTALRRLSAGKVSSLAASPKTSTSPSPVLNALRS 250
            ...|.|          .|:.||:|:....||.           |..||:.:.|::.|       |
Mouse   190 GALFFS----------RINKTSSASTSDPAGP-----------SYAAATLQASSAAS-------S 226

  Fly   251 VSPTPLDAKPLDRNRASLLFGDDDEDVKDAEVNAKKQRLSKHLEADKDRRRLEQEKERESRKKKS 315
            .||.|            .:.|..                ||..|..|.:|:|:
Mouse   227 ASPVP------------KVVGSS----------------SKPQEPPKGKRKLD------------ 251

  Fly   316 SRHSLDKSISKED-KPPAKEHNSSSREKSTAKEEKEQLRKEERSHSKEEKSRRKEKSKHDHRSSD 379
                    :|.|| |||:|    .|...||.|..|
Mouse   252 --------LSLEDRKPPSK----PSAGPSTLKRPK------------------------------ 274

  Fly   380 TSNSKESSRPTAQKRHSSPTAVAVTPAKKQKIVDTAIQYRP----------------LNQLLKGV 428
              .|..|..|.|        |.|.|||::      |:..:|                |.::|:||
Mouse   275 --LSVPSRTPAA--------APASTPAQR------AVPGKPRGEGTEPRGARTGPQELGKILQGV 323

  Fly   429 VLVISGIQNPDRADLRSKAVALGAKYKADWGSGCTHLICAFKNTPKYNQVKG-KGKIVTRSWIEK 492
            |:|:||.|||.|::||.||:.|||||:.||....|||||||.|||||:||.| .|:||.:.|:..
Mouse   324 VVVLSGFQNPFRSELRDKALELGAKYRPDWTPDSTHLICAFANTPKYSQVLGLGGRIVRKEWVLD 388

  Fly   493 CYELKKYLPWRRYAL-----DTNDIG-------------------QPESDEELCDEATRPRRDSS 533
            |:.:::.||.|||.:     .:.|.|                   ||::..:....::.||..:.
Mouse   389 CHHMRRRLPSRRYLMAGLGSSSEDEGDSHSESGEDEAPKLPQKRPQPKAKTQAAGPSSPPRPPTP 453

  Fly   534 KDDVAML---EDSKLTALADQNDVEMNPDALSGIDTEDELQRVAEENKTKKAKLRTTVKTKSQDI 595
            |:..|..   :|:..|. .::::...|....|| ||||||:|||::.:.::.   ...:...:|.
Mouse   454 KETKAPSPGPQDNSDTE-GEESEGRDNGAEDSG-DTEDELRRVAKQREQRQP---PAPEENGEDP 513

  Fly   596 YEVSTDE 602
            |..||||
Mouse   514 YAGSTDE 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
XRCC1	NP_572217.1	XRCC1_N	1..144	CDD:280080	67/146 (46%)
XRCC1	NP_572217.1	BRCT	420..494	CDD:278934	43/90 (48%)
Xrcc1	NP_033558.3	XRCC1_N	1..150	CDD:280080	69/148 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..315		35/194 (18%)
		BRCT	318..389	CDD:278934	41/70 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..537		28/121 (23%)
		BRCT	538..613	CDD:214602
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837143
Domainoid	1	1.000	136	1.000	Domainoid score	I4923
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52684
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007184
OrthoInspector	1	1.000	-	-		oto93649
orthoMCL	1	0.900	-	-		OOG6_106425
Panther	1	1.100	-	-	LDO	PTHR11370
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5875
SonicParanoid	1	1.000	-	-		X6063
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.970