DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3309 and dennd6aa

DIOPT Version :9

Sequence 1:	NP_572216.1	Gene:	CG3309 / 31450	FlyBaseID:	FBgn0029756	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	XP_021335275.1	Gene:	dennd6aa / 449814	ZFINID:	ZDB-GENE-041010-63	Length:	600	Species:	Danio rerio

Alignment Length:	609	Identity:	250/609 - (41%)
Similarity:	362/609 - (59%)	Gaps:	64/609 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 EPSASDWVNFSQWMHCFCVVTFDLNLGQALEHVYPPAFMPSDQEVSNICYMAFPDSNSGCMGDTK 98
            ||....|..||.|:||.|||.|||.||||:|.:||.....:::|.::|||::||||||||:|||:
Zfish    42 EPLLLPWDRFSSWLHCICVVGFDLELGQAVEVIYPHHSKLTEKEKTSICYLSFPDSNSGCLGDTQ 106

  Fly    99 FHMRLRCTTRRDS-----LPGYNAECSPALRQDGSHYWGFVYFRQKRDANLPRGYFQKSFIIITR 158
            |..|.|....|.|     |..::.:...:|::|..:|:|:|||||.||.:|.|||||||.::|::
Zfish   107 FCFRFRQAAGRKSSLGCFLEHFDRDAPVSLKKDQGYYYGYVYFRQVRDKSLKRGYFQKSLVLISK 171

  Fly   159 LPFFNLYYDILSQLAPRYFEEGTDVLRLASEQINRQWPGLRVGKPLQLPLLDCSYQICIPRTSSS 223
            ||:...::.:|..:||.|||:....|..|...|:| ||....||.|.||::....::.|| |...
Zfish   172 LPYVTFFHSLLKLIAPEYFEKQEPCLEAACNDIDR-WPTPCPGKILSLPIMGVVMKLRIP-TCYD 234

  Fly   224 RKSTADGGIAGGAVESPPAMAACPAAKVLASVNEIELFRSLDFVMEQLYTLWELVITAEPIVVVG 288
            :..|:.      .|:|.|:.:  ..:.:|.:|:|::|||....|...:..|||||:..|.:||:.
Zfish   235 KPGTSQ------LVQSTPSDS--QVSIILPTVHEVDLFRCFHPVFFHIQMLWELVLLGEALVVMA 291

  Fly   289 TSPADCSHMVQTLLAMIAPLEYCAEARPYFTIHDSEFREFTQECSSKTTLPACILGVTNPFFVKL 353
            .|||:.|..|..|::.|:||.||::.|||||||||||:|:|....:.   |:.|||||||||.|.
Zfish   292 PSPAESSDTVLALVSCISPLRYCSDFRPYFTIHDSEFKEYTTRTQAP---PSVILGVTNPFFAKT 353

  Fly   354 LKDWPHMLRLVDNQKNMQQQQHLLLGQKHARNIASATSFSSSTELGGRIALKSNTNLNGSSSSSN 418
            |:.|||::|:.|                          ..::.|:..::.:|...||....
Zfish   354 LQHWPHIIRIGD--------------------------MKTAGEMAKQMKVKKLKNLKTLD---- 388

  Fly   419 GSGDASSAGLHSKYRPYLKKDKALIKKVLLGMKTKRPEHVQTALIRRHLLELTQSFMIPLERYMA 483
                 |..|:::.|:|:|.||:.:||::..|::.|||...|.|::||:.|||||||:||||||:|
Zfish   389 -----SKPGVYTAYKPFLNKDEDIIKQLQKGVQQKRPSAAQNAILRRYFLELTQSFIIPLERYVA 448

  Fly   484 SLMPLQKDISPFKSAPNANSFKLDDFLGTLETAGPQLTSPLKGDWKGLYRRFFRSPNFRGWYGAR 548
            |||||||.|||:||.|....|..|:|:.|||.|||||||.|||||.||||:|.|||||.||:..|
Zfish   449 SLMPLQKSISPWKSPPQLRPFNQDEFMKTLEKAGPQLTSRLKGDWIGLYRQFLRSPNFDGWFRNR 513

  Fly   549 HRELQLTLQDLQLQALSVANLEHWAHDKQEVEIIDMILKLKQKLNLYGDKATQLEGN----NGST 609
            .:|:...|:.|.|:||...:|........|||.:|::||||:||       ||.|.:    ...|
Zfish   514 RKEMLQKLEALHLEALCEEDLTLRIQKHTEVETVDLVLKLKEKL-------TQAEKDQLPVKAGT 571

  Fly   610 QQQIRAQIECMKGLLPPDLKNVVN 633
            ..:::|.|:.:...||.||:.:::
Zfish   572 LAKLQAHIDTIILTLPEDLQGILH 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3309	NP_572216.1	SPA	270..368	CDD:285780	49/97 (51%)
dennd6aa	XP_021335275.1	Avl9	57..>191	CDD:331426	61/133 (46%)
		DENN	164..351	CDD:325068	77/199 (39%)
		SPA	262..367	CDD:312210	53/133 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595147
Domainoid	1	1.000	199	1.000	Domainoid score	I3010
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	456	1.000	Inparanoid score	I1561
OMA	1	1.010	-	-		QHG55704
OrthoDB	1	1.010	-	-		D174763at33208
OrthoFinder	1	1.000	-	-		FOG0003104
OrthoInspector	1	1.000	-	-		otm24612
orthoMCL	1	0.900	-	-		OOG6_102254
Panther	1	1.100	-	-	O	PTHR13677
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3543
SonicParanoid	1	1.000	-	-		X2076
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.940