DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3309 and dennd6b

DIOPT Version :9

Sequence 1:	NP_572216.1	Gene:	CG3309 / 31450	FlyBaseID:	FBgn0029756	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_956359.1	Gene:	dennd6b / 337436	ZFINID:	ZDB-GENE-030131-9382	Length:	575	Species:	Danio rerio

Alignment Length:	629	Identity:	257/629 - (40%)
Similarity:	369/629 - (58%)	Gaps:	61/629 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MAPSLDTTEREREHQNVDATNSNSEPSASDWVNFSQWMHCFCVVTFDLNLGQALEHVYPPAFMPS 74
            |.|...:...|...:.|..|...|||    |..||.|:.|.|||||||.||||:|.|||.....:
Zfish     1 MDPFDSSESLEGPSKAVATTAEFSEP----WSRFSAWLECVCVVTFDLELGQAIELVYPHDVKLT 61

  Fly    75 DQEVSNICYMAFPDSNSGCMGDTKFHMRLRCTTRRDSL-----PGYNAECSPALRQDGSHYWGFV 134
            ::|.::|||::||||.|||:|||:|..|||.:..|.|.     ..||.:...:|:::.:|..|:|
Zfish    62 EKEKTSICYLSFPDSYSGCLGDTQFSFRLRQSVGRSSSWFGQEDVYNRDAPVSLQKEHAHLHGYV 126

  Fly   135 YFRQKRDANLPRGYFQKSFIIITRLPFFNLYYDILSQLAPRYFEEGTDVLRLASEQINRQWPGLR 199
            ||||.:||.:.|||||||.::::||||.||::.:|..:||.|||:....|.....:|: |||...
Zfish   127 YFRQVKDATVKRGYFQKSLVVVSRLPFVNLFHSLLQVIAPEYFEKLEPCLETVCNEID-QWPAPV 190

  Fly   200 VGKPLQLPLLDCSYQICIPRTSSSRKSTADGGIAGGAVESPPAMAACPAAKVLASVNEIELFRSL 264
            .|:.|.||::....||.||    |:..||:    |..|:........||..||.||:|::||:..
Zfish   191 PGQTLNLPVMGVVMQIRIP----SKVETAE----GSPVKQQQTENLLPAPTVLPSVHELDLFKCF 247

  Fly   265 DFVMEQLYTLWELVITAEPIVVVGTSPADCSHMVQTLLAMIAPLEYCAEARPYFTIHDSEFREFT 329
            ..|:..:..||||::..||:|::..||...|..|..|::.|.||.|..:.|||||||||||:|:|
Zfish   248 QSVLIHVQMLWELMLLGEPVVIMAPSPTVSSETVLALVSSIDPLHYFGDYRPYFTIHDSEFKEYT 312

  Fly   330 QECSSKTTLPACILGVTNPFFVKLLKDWPHMLRLVDNQKNMQQQQHLLLGQKHARNIASATSFSS 394
            ....:.   |..|||||||||:|..:.|||::||.:                          ...
Zfish   313 TRTQAP---PNVILGVTNPFFIKTFQSWPHIIRLGE--------------------------LKM 348

  Fly   395 STELGGRIALKSNTNLNGSSSSSNGSGDASSAGLHSKYRPYLKKDKALIKKVLLGMKTKRPEHVQ 459
            |.:|..::.:|....|....:.:         |:::.|:.:|.|||.|||::|.|::.|||..||
Zfish   349 SGDLPKQVKIKKLAKLKTLDTKT---------GIYTAYKTFLHKDKTLIKRLLKGIQKKRPSEVQ 404

  Fly   460 TALIRRHLLELTQSFMIPLERYMASLMPLQKDISPFKSAPNANSFKLDDFLGTLETAGPQLTSPL 524
            :|::||||||.||||::|||:|:.:|||.|:.:||:|:.|...||..|:|:.|||.||||||  |
Zfish   405 SAILRRHLLEQTQSFILPLEQYLETLMPPQRSVSPWKTPPQIRSFNQDEFMKTLEQAGPQLT--L 467

  Fly   525 KGDWKGLYRRFFRSPNFRGWYGARHRELQLTLQDLQLQALSVANLEHWAHDKQEVEIIDMILKLK 589
            |||:.|||||||:||||.|||..||||:...::.|.|:|:..|:|..|..||.||||:|:||||:
Zfish   468 KGDFTGLYRRFFKSPNFDGWYRFRHREMSQKVECLHLEAICAADLLTWTKDKSEVEIVDLILKLR 532

  Fly   590 QKLNLYGDKATQLEGNNGSTQQQIRAQIECMKGLLPPDLKNVVN 633
            :|  |...:..||.... ...:::...|:.:...||.||:.|::
Zfish   533 EK--LMRARKHQLPVKE-ELLERLEQSIQTIISSLPEDLQTVLH 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3309	NP_572216.1	SPA	270..368	CDD:285780	45/97 (46%)
dennd6b	NP_956359.1	DENN	143..>293	CDD:299760	57/158 (36%)
dennd6b	NP_956359.1	SPA	242..348	CDD:285780	48/134 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595146
Domainoid	1	1.000	199	1.000	Domainoid score	I3010
eggNOG	1	0.900	-	-		E1_KOG2432
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	456	1.000	Inparanoid score	I1561
OMA	1	1.010	-	-		QHG55704
OrthoDB	1	1.010	-	-		D174763at33208
OrthoFinder	1	1.000	-	-		FOG0003104
OrthoInspector	1	1.000	-	-		otm24612
orthoMCL	1	0.900	-	-		OOG6_102254
Panther	1	1.100	-	-	LDO	PTHR13677
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3543
SonicParanoid	1	1.000	-	-		X2076
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800