Protein Alignment CG3309 and DENND6A

DIOPT Version :9

• Sequence 1: NP_572216.1
• Gene: CG3309 / 31450
• FlyBaseID: FBgn0029756
• Length: 634
• Species: Drosophila melanogaster
• Sequence 2: NP_689891.1
• Gene: DENND6A / 201627
• HGNCID: 26635
• Length: 608
• Species: Homo sapiens
• Alignment Length: 598
• Identity: 240/598 - (40%)
• Similarity: 354/598 - (59%)
• Gaps: 55/598 - (9%)

  Fly    40 WVNFSQWMHCFCVVTFDLNLGQALEHVYPPAFMPSDQEVSNICYMAFPDSNSGCMGDTKFHMRLR 104
            |.:||.|:||.|||.|||.||||:|.:||.....:|:|.:||||::||||||||:|||:|..|.|
Human    55 WDSFSAWLHCVCVVGFDLELGQAVEVIYPQHSKLTDREKTNICYLSFPDSNSGCLGDTQFCFRFR 119

  Fly   105 CTT-RRDS----LPGYNAECSPALRQDGSHYWGFVYFRQKRDANLPRGYFQKSFIIITRLPFFNL 164
            .:: ||.|    |..::.:....|::|.::::|:|||||.||..|.|||||||.::|::||:.:.
Human   120 QSSGRRVSLHCLLDQFDKDLPVYLKKDPAYFYGYVYFRQVRDKTLKRGYFQKSLVLISKLPYIHF 184

  Fly   165 YYDILSQLAPRYFEEGTDVLRLASEQINRQWPGLRVGKPLQLPLLDCSYQICIPRTSSSRKSTAD 229
            ::.:|.|:||.|||:....|..|...::| ||....||.|.||::....::.|| |...:..|..
Human   185 FHTVLKQIAPEYFEKNEPYLEAACNDVDR-WPAPVPGKTLHLPIMGVVMKVRIP-TCHDKPGTTQ 247

  Fly   230 GGIAGGAVESPPAMAACPAAKVLASVNEIELFRSLDFVMEQLYTLWELVITAEPIVVVGTSPADC 294
                   :...........:.:|.:|:|:::||....|......|||||:..||:||:..||::.
Human   248 -------IVQLTQQVDTNISVILPTVHEVDIFRCFCPVFLHSQMLWELVLLGEPLVVMAPSPSES 305

  Fly   295 SHMVQTLLAMIAPLEYCAEARPYFTIHDSEFREFTQECSSKTTLPACILGVTNPFFVKLLKDWPH 359
            |..|..|:..|:||:|.::.|||||||||||:|:|....:.   |:.|||||||||.|.|:.|||
Human   306 SETVLALVNCISPLKYFSDFRPYFTIHDSEFKEYTTRTQAP---PSVILGVTNPFFAKTLQHWPH 367

  Fly   360 MLRLVDNQKNMQQQQHLLLGQKHARNIASATSFSSSTELGGRIALKSNTNLNGSSSSSNGSGDAS 424
            ::|:.|                          ...:.|:..::.:|...||....         |
Human   368 IIRIGD--------------------------LKPTGEIPKQVKVKKLKNLKTLD---------S 397

  Fly   425 SAGLHSKYRPYLKKDKALIKKVLLGMKTKRPEHVQTALIRRHLLELTQSFMIPLERYMASLMPLQ 489
            ..|:::.|:|||.:|:.:||::..|::.|||...|:.::||:.|||||||:||||||:|||||||
Human   398 KPGVYTSYKPYLNRDEEIIKQLQKGVQQKRPSEAQSVILRRYFLELTQSFIIPLERYVASLMPLQ 462

  Fly   490 KDISPFKSAPNANSFKLDDFLGTLETAGPQLTSPLKGDWKGLYRRFFRSPNFRGWYGARHRELQL 554
            |.|||:||.|....|..::|:.|||..||||||.:||||.||||.|.:||||.||:..|.:|:..
Human   463 KSISPWKSPPQLRQFLPEEFMKTLEKTGPQLTSRIKGDWIGLYRHFLKSPNFDGWFKTRRKEMTQ 527

  Fly   555 TLQDLQLQALSVANLEHWAHDKQEVEIIDMILKLKQKLNLYGDKATQLEGNNGSTQQQIRAQIEC 619
            .|:.|.|:||...:|..|.....|||.:|::||||.|| |..|:  :.......|.:::|..|:.
Human   528 KLEALHLEALCEEDLLLWIQKHTEVETVDLVLKLKNKL-LQADR--EHLPVKPDTMEKLRTHIDA 589

  Fly   620 MKGLLPPDLKNVV 632
            :...||.||:.::
Human   590 IILALPEDLQGIL 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3309	NP_572216.1	SPA	270..368	CDD:285780	48/97 (49%)
DENND6A	NP_689891.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..48
		Avl9	64..>201	CDD:331426	66/136 (49%)
		DENN	171..359	CDD:325068	72/199 (36%)
		SPA	270..373	CDD:312210	50/105 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159093
Domainoid	1	1.000	222	1.000	Domainoid score	I2600
eggNOG	1	0.900	-	-		E1_KOG2432
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13503
Inparanoid	1	1.050	490	1.000	Inparanoid score	I1428
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55704
OrthoDB	1	1.010	-	-		D174763at33208
OrthoFinder	1	1.000	-	-		FOG0003104
OrthoInspector	1	1.000	-	-		otm42031
orthoMCL	1	0.900	-	-		OOG6_102254
Panther	1	1.100	-	-	O	PTHR13677
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2076
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770