Protein Alignment HMBS and Hmbs

DIOPT Version :10

• Sequence 1: NP_000181.2
• Gene: HMBS / 3145
• HGNCID: 4982
• Length: 361
• Species: Homo sapiens
• Sequence 2: NP_612103.1
• Gene: Hmbs / 46140
• FlyBaseID: FBgn0010786
• Length: 652
• Species: Drosophila melanogaster
• Alignment Length: 330
• Identity: 166/330 - (50%)
• Similarity: 210/330 - (63%)
• Gaps: 24/330 - (7%)

Human    15 SPKMRVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTK 79
            |.:.:|||||:|||:||.|||..|:..|:..||..:|||..|||.||::|:.:|.|||||||||:
  Fly     2 SAQEKVIRVGSRKSELALIQTKHVIGRLQKLYPKQKFEIHTMSTFGDRVLNVSLPKIGEKSLFTR 66

Human    80 ELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPEKSVVG 144
            :||.||....||.||||||||||.||.|..|||:.:||:..||:|....|.|.|:.:||:.||:|
  Fly    67 DLEDALRNGGVDFVVHSLKDLPTALPTGMAIGAVLEREDARDALVLRENFKGHTIASLPKGSVIG 131

Human   145 TSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLD-EQQEFSAIILATAGLQRMGWHNRVGQILHP 208
            ||||||.||::|.:|||....|||||||||.||| ...:||.||||.|||.||||.:|:.|:|.|
  Fly   132 TSSLRRTAQIRRMYPHLTVCDIRGNLNTRLAKLDAADSKFSGIILAQAGLVRMGWMSRISQVLEP 196

Human   209 EECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTAMK- 272
            .:.:||||||||.||.||.|..:|.::..|....|..|.:|||:||:.|.||||.||||.:.:|
  Fly   197 TDLLYAVGQGALAVECRANDDQVLAMLQKLMCLNTTCRILAERSFLKTLGGGCSAPVAVWSNLKG 261

Human   273 ---DGQ-----LYLTGGVWSLDGSDSIQETMQATIHVPAQHEDGPEDDPQLVGITARNIPRGPQL 329
               :|.     |.|||.||||||:..|:..:..     |.:|...|.|.:         .||.|.
  Fly   262 EPLNGNSQEVGLSLTGAVWSLDGAIEIRNHLAC-----ALNEQKLEGDQR---------KRGAQE 312

Human   330 AAQNL 334
            |...|
  Fly   313 ATSQL 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HMBS	NP_000181.2	PBP2_HuPBGD_like	20..299	CDD:270363	156/288 (54%)
Hmbs	NP_612103.1	PBP2_HuPBGD_like	7..296	CDD:270363	156/293 (53%)