DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm3 and MCM3

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_010882.1	Gene:	MCM3 / 856680	SGDID:	S000000758	Length:	971	Species:	Saccharomyces cerevisiae

Alignment Length:	925	Identity:	391/925 - (42%)
Similarity:	535/925 - (57%)	Gaps:	130/925 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 YVDFLDDEEDQGIYAGHVKDMIAEKSK------------RLIVNVNDLKRKNPQRALGLLSNAAD 68
            |.|..||.:::.:......|.:.::.|            |:|::::||:..:.....|:|...|.
Yeast    56 YNDDQDDADERDLLGDDDGDDLEKEKKAASSTSLNILPHRIIISLDDLREFDRSFWSGILVEPAY 120

  Fly    69 EQLAFGRALKEYASTVD----PGYAKM--HEDLFVGFEGCFGNRHVTPRSLTSIYLGNMVCVEGI 127
            ......:||.:.|.::|    |..:.:  .....:.|:|.||...::||:||:.:|..:|.||||
Yeast   121 FIPPAEKALTDLADSMDDVPHPNASAVSSRHPWKLSFKGSFGAHALSPRTLTAQHLNKLVSVEGI 185

  Fly   128 VTKVSLIRPKVVRSVHYCPNTRKVMERKYTDLTS--FEAVPSGAAYPTKDEDGNLLETEYGLSVY 190
            |||.||:|||::|||||...|.:...|.|||.|:  ...:|:.|.|||:|.:||.|.||||.|.:
Yeast   186 VTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYSTF 250

  Fly   191 KDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSYRCL-PGKRGGYTSGT-- 252
            .|||.:|:|||||.|||||||||:|::.||||||:.||||||.:||.::.| .|......|.|
Yeast   251 IDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKSLGAGGMNQSNSNTLI 315

  Fly   253 -FRTVLLANNISLLSKESNLDISRE-----DIMLCKKLAKNNDIFELLSKSLAPSIHGHAYVKQA 311
             |:|::|.|.:..|...|....:|:     ||....||:|..|||::||:||||||:||.::|:|
Yeast   316 GFKTLILGNTVYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIFDILSQSLAPSIYGHDHIKKA 380

  Fly   312 ILCLLLGGVEKILPNGTRLRGDINVLLIGDPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAA 376
            ||.:|:|||||.|.||:.||||||:|::||||.|||||||:|||||..||.||||||||||||||
Yeast   381 ILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAA 445

  Fly   377 VTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARC 441
            ||||:||||||||||||||||||||||||||||:|:||.||||||||..|||:|||||.:|||||
Yeast   446 VTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGIHTTLNARC 510

  Fly   442 SVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPK 506
            ||:||||||:|:||..:.|.:||.|.||||||||||||:.|.|:...|:.||:||:|.|||..|.
Yeast   511 SVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRDRSISEHVLRTHRYLPPG 575

  Fly   507 EADGEP--------LSMG-------SSYADSLSFVSSSEEKKDTEVYEKYDALLH-----GKSRQ 551
            ..:|||        |::|       ..:::|.:.|.:..|..:..|:||::.||.     .|::.
Yeast   576 YLEGEPVRERLNLSLAVGEDADINPEEHSNSGAGVENEGEDDEDHVFEKFNPLLQAGAKLAKNKG 640

  Fly   552 RHE-----KILSVEFMRKYIHIAK-CMKPKLGEQACEAIANEYSRLRSQEAVETDVARTQPITAR 610
            .:.     |::::.|:|||:..|| .:.|:|.::|...|...|:.||:.     |..:..|||||
Yeast   641 NYNGTEIPKLVTIPFLRKYVQYAKERVIPQLTQEAINVIVKNYTDLRND-----DNTKKSPITAR 700

  Fly   611 TLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAY---------------FKKVLDK----DR 656
            ||||||||:||||:.|:||:|...||..|..|::||.               :::.|.|    ..
Yeast   701 TLETLIRLATAHAKVRLSKTVNKVDAKVAANLLRFALLGEDIGNDIDEEESEYEEALSKRSPQKS 765

  Fly   657 PSKRRR------NSGSDAEDD--NGEASSQR---SPSRRSKRTRTATVGADSDEEDIEPPQP--- 707
            |.||:|      ||||..:..  ...|||..   |.:||..|.:.....|..|:.||..|.|
Yeast   766 PKKRQRVRQPASNSGSPIKSTPRRSTASSVNATPSSARRILRFQDDEQNAGEDDNDIMSPLPADE 830

  Fly   708 ----------------------------DAGDLTRRETRRSLPARSVAMLMASPSSEEQSVAT-S 743
                                        .:|.||...|.| ||..|.|   .....::|||.: .
Yeast   831 EAELQRRLQLGLRVSPRRREHLHAPEEGSSGPLTEVGTPR-LPNVSSA---GQDDEQQQSVISFD 891

  Fly   744 TTEPAIISDARLGEFKNNLQRLFREA--REQSLALARITTAIN--VGSQEPFTAGEIEAAVHRMT 804
            ..||..||..||......:.||.:..  .|:|..:|.:...||  :..:|.|:|.|..|.:..|:
Yeast   892 NVEPGTISTGRLSLISGIIARLMQTEIFEEESYPVASLFERINEELPEEEKFSAQEYLAGLKIMS 956

  Fly   805 EDNQIMVADDIVFLI 819
            :.|.:|||||.|:.:
Yeast   957 DRNNLMVADDKVWRV 971

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	18/100 (18%)
Mcm3	NP_511048.2	MCM	106..648	CDD:214631	308/593 (52%)
MCM3	NP_010882.1	MCM_N	25..>137	CDD:405270	16/80 (20%)
MCM3	NP_010882.1	MCM	166..738	CDD:214631	308/576 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346383
Domainoid	1	1.000	319	1.000	Domainoid score	I183
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1791
Inparanoid	1	1.050	592	1.000	Inparanoid score	I137
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53768
OrthoFinder	1	1.000	-	-		FOG0004045
OrthoInspector	1	1.000	-	-		oto100028
orthoMCL	1	0.900	-	-		OOG6_101598
Panther	1	1.100	-	-	LDO	PTHR11630
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R693
SonicParanoid	1	1.000	-	-		X2791
TreeFam	1	0.960	-	-
	15	14.790