Protein Alignment Mcm3 and MCM3

DIOPT Version :10

• Sequence 1: NP_511048.2
• Gene: Mcm3 / 31449
• FlyBaseID: FBgn0284442
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_010882.1
• Gene: MCM3 / 856680
• SGDID: S000000758
• Length: 971
• Species: Saccharomyces cerevisiae
• Alignment Length: 925
• Identity: 391/925 - (42%)
• Similarity: 535/925 - (57%)
• Gaps: 130/925 - (14%)

  Fly    16 YVDFLDDEEDQGIYAGHVKDMIAEKSK------------RLIVNVNDLKRKNPQRALGLLSNAAD 68
            |.|..||.:::.:......|.:.::.|            |:|::::||:..:.....|:|...|.
Yeast    56 YNDDQDDADERDLLGDDDGDDLEKEKKAASSTSLNILPHRIIISLDDLREFDRSFWSGILVEPAY 120

  Fly    69 EQLAFGRALKEYASTVD----PGYAKM--HEDLFVGFEGCFGNRHVTPRSLTSIYLGNMVCVEGI 127
            ......:||.:.|.::|    |..:.:  .....:.|:|.||...::||:||:.:|..:|.||||
Yeast   121 FIPPAEKALTDLADSMDDVPHPNASAVSSRHPWKLSFKGSFGAHALSPRTLTAQHLNKLVSVEGI 185

  Fly   128 VTKVSLIRPKVVRSVHYCPNTRKVMERKYTDLTS--FEAVPSGAAYPTKDEDGNLLETEYGLSVY 190
            |||.||:|||::|||||...|.:...|.|||.|:  ...:|:.|.|||:|.:||.|.||||.|.:
Yeast   186 VTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYSTF 250

  Fly   191 KDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSYRCL-PGKRGGYTSGT-- 252
            .|||.:|:|||||.|||||||||:|::.||||||:.||||||.:||.::.| .|......|.|
Yeast   251 IDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKSLGAGGMNQSNSNTLI 315

  Fly   253 -FRTVLLANNISLLSKESNLDISRE-----DIMLCKKLAKNNDIFELLSKSLAPSIHGHAYVKQA 311
             |:|::|.|.:..|...|....:|:     ||....||:|..|||::||:||||||:||.::|:|
Yeast   316 GFKTLILGNTVYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIFDILSQSLAPSIYGHDHIKKA 380

  Fly   312 ILCLLLGGVEKILPNGTRLRGDINVLLIGDPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAA 376
            ||.:|:|||||.|.||:.||||||:|::||||.|||||||:|||||..||.||||||||||||||
Yeast   381 ILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAA 445

  Fly   377 VTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARC 441
            ||||:||||||||||||||||||||||||||||:|:||.||||||||..|||:|||||.:|||||
Yeast   446 VTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGIHTTLNARC 510

  Fly   442 SVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPK 506
            ||:||||||:|:||..:.|.:||.|.||||||||||||:.|.|:...|:.||:||:|.|||..|.
Yeast   511 SVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRDRSISEHVLRTHRYLPPG 575

  Fly   507 EADGEP--------LSMG-------SSYADSLSFVSSSEEKKDTEVYEKYDALLH-----GKSRQ 551
            ..:|||        |::|       ..:::|.:.|.:..|..:..|:||::.||.     .|::.
Yeast   576 YLEGEPVRERLNLSLAVGEDADINPEEHSNSGAGVENEGEDDEDHVFEKFNPLLQAGAKLAKNKG 640

  Fly   552 RHE-----KILSVEFMRKYIHIAK-CMKPKLGEQACEAIANEYSRLRSQEAVETDVARTQPITAR 610
            .:.     |::::.|:|||:..|| .:.|:|.::|...|...|:.||:.     |..:..|||||
Yeast   641 NYNGTEIPKLVTIPFLRKYVQYAKERVIPQLTQEAINVIVKNYTDLRND-----DNTKKSPITAR 700

  Fly   611 TLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAY---------------FKKVLDK----DR 656
            ||||||||:||||:.|:||:|...||..|..|::||.               :::.|.|    ..
Yeast   701 TLETLIRLATAHAKVRLSKTVNKVDAKVAANLLRFALLGEDIGNDIDEEESEYEEALSKRSPQKS 765

  Fly   657 PSKRRR------NSGSDAEDD--NGEASSQR---SPSRRSKRTRTATVGADSDEEDIEPPQP--- 707
            |.||:|      ||||..:..  ...|||..   |.:||..|.:.....|..|:.||..|.|
Yeast   766 PKKRQRVRQPASNSGSPIKSTPRRSTASSVNATPSSARRILRFQDDEQNAGEDDNDIMSPLPADE 830

  Fly   708 ----------------------------DAGDLTRRETRRSLPARSVAMLMASPSSEEQSVAT-S 743
                                        .:|.||...|.| ||..|.|   .....::|||.: .
Yeast   831 EAELQRRLQLGLRVSPRRREHLHAPEEGSSGPLTEVGTPR-LPNVSSA---GQDDEQQQSVISFD 891

  Fly   744 TTEPAIISDARLGEFKNNLQRLFREA--REQSLALARITTAIN--VGSQEPFTAGEIEAAVHRMT 804
            ..||..||..||......:.||.:..  .|:|..:|.:...||  :..:|.|:|.|..|.:..|:
Yeast   892 NVEPGTISTGRLSLISGIIARLMQTEIFEEESYPVASLFERINEELPEEEKFSAQEYLAGLKIMS 956

  Fly   805 EDNQIMVADDIVFLI 819
            :.|.:|||||.|:.:
Yeast   957 DRNNLMVADDKVWRV 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	13..101	CDD:464206	19/102 (19%)
		MCM	106..648	CDD:214631	308/593 (52%)
MCM3	NP_010882.1	MCM_N	25..143	CDD:464206	17/86 (20%)
		MCM	166..738	CDD:475121	308/576 (53%)