Protein Alignment Mcm3 and MCM6

DIOPT Version :9

• Sequence 1: NP_511048.2
• Gene: Mcm3 / 31449
• FlyBaseID: FBgn0284442
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_011314.2
• Gene: MCM6 / 852673
• SGDID: S000003169
• Length: 1017
• Species: Saccharomyces cerevisiae
• Alignment Length: 930
• Identity: 256/930 - (27%)
• Similarity: 397/930 - (42%)
• Gaps: 259/930 - (27%)

  Fly     6 EQFIKDIQREYVDFLDDEEDQGIYAGHVKDMIAEKSKRLIVNVNDLK-RKNPQRALGLLSNAADE 69
            |||::|..   |...|..|.:.:|...::.|.......:.::...|. |:|     |.|:.|..|
Yeast   116 EQFLEDFS---VQSTDTGEVEKVYRAQIEFMKIYDLNTIYIDYQHLSMREN-----GALAMAISE 172

  Fly    70 Q----LAF-----GRALKEYA------------STVDPGYAKMHEDLFVGFEG------------ 101
            |    |.|     .|.:::||            |..|.|.|...|.......|
Yeast   173 QYYRFLPFLQKGLRRVVRKYAPELLNTSDSLKRSEGDEGQADEDEQQDDDMNGSSLPRDSGSSAA 237

  Fly   102 ------CFGNRHVTP------------------------RSLTSIYLGNMVCVEGIVTKVSLIRP 136
                  ....|.:|.                        |.:.|..:|:::.:.|.||:.|.:||
Yeast   238 PGNGTSAMATRSITTSTSPEQTERVFQISFFNLPTVHRIRDIRSEKIGSLLSISGTVTRTSEVRP 302

  Fly   137 KVVRSVHYCPNTRKVMER-----KYTDLTSFEAVPSGAAYPTKDEDGNLLETEYGLSVYKDHQTL 196
            ::.::...|...|.:::.     |||:.| |...||       .|:..........|.:.|.|.:
Yeast   303 ELYKASFTCDMCRAIVDNVEQSFKYTEPT-FCPNPS-------CENRAFWTLNVTRSRFLDWQKV 359

  Fly   197 TIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVG--------SYRCLPG--------KR 245
            .|||...:.|.|.:||::|::...|.|:|.|||||.:..|        :...|||        .|
Yeast   360 RIQENANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDVTQLGLPGVKPSSTLDTR 424

  Fly   246 G------GYTSG------------TFRTVLLA-------NNISLLSKESNLD------------- 272
            |      |..||            |::...||       :||...|.::|.:
Yeast   425 GISKTTEGLNSGVTGLRSLGVRDLTYKISFLACHVISIGSNIGASSPDANSNNRETELQMAANLQ 489

  Fly   273 ------------------ISREDIMLCKKLAKNNDIFELLSKSLAPSIHGHAYVKQAILCLLLGG 319
                              :|.::|...|::.|:..|::.|.:|:||::.||..||:.||..:|||
Yeast   490 ANNVYQDNERDQEVFLNSLSSDEINELKEMVKDEHIYDKLVRSIAPAVFGHEAVKKGILLQMLGG 554

  Fly   320 VEKILPNGTRLRGDINVLLIGDPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETG 384
            |.|....|.:||||||:.::||||.:|||.|:||:..|||::.|:|:.||..||||||..|:|.|
Yeast   555 VHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSGKASSAAGLTAAVVRDEEGG 619

  Fly   385 ERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARCSVLAAANP 449
            :..:||||::|||.|:.||||||||...|:.||||.|||..::|:||||||:||||.|:||||||
Yeast   620 DYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEAMEQQTISIAKAGIHATLNARTSILAAANP 684

  Fly   450 VYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPKEADGEPLS 514
            |.|||::..:...|:.:...::|||||.||:||..:..:|..::.|:|.:|.
Yeast   685 VGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCNEKIDTELASHIVDLHM------------- 736

  Fly   515 MGSSYADSLSFVSSSEEKKDTEVYEKYDALLHGKSRQRHEKILSVEFMRKYIHIAKCMKPKLGEQ 579
                             |:|..:                |...|.|.:|:||..|:..||.|.::
Yeast   737 -----------------KRDEAI----------------EPPFSAEQLRRYIKYARTFKPILTKE 768

  Fly   580 ACEAIANEYSRLRSQEAVETDVARTQ-PITARTLETLIRLSTAHARARMSKSVTIDDAHAAIELV 643
            |...:..:|..||..:|  ...:|:. .||.|.||::||||.|.|||.....:|......|.:|:
Yeast   769 ARSYLVEKYKELRKDDA--QGFSRSSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLL 831

  Fly   644 QFAYFKKVLDKDRPSKRRRNSGSDAEDDNGEASSQRSPSRRSKRTRTATVGADSDEED------- 701
            :.:..:..:|         :...|.|.||.|:.|.            |..|.:.|.:|
Yeast   832 RQSIIRVDVD---------DVEMDEEFDNIESQSH------------AASGNNDDNDDGTGSGVI 875

  Fly   702 -IEPPQPDAGDLTRRETRRSLPARSVAMLMASPSSEEQSVATSTTEPAIISDARLGEFKNNLQRL 765
             .|||    .|:...::..:          |.|.:.|:...|.|.:          ::.:.:..:
Yeast   876 TSEPP----ADIEEGQSEAT----------ARPGTSEKKKTTVTYD----------KYVSMMNMI 916

  Fly   766 FREAREQSLALARITTAINV 785
            .|:..|.....|...||:::
Yeast   917 VRKIAEVDREGAEELTAVDI 936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	22/104 (21%)
		MCM	106..648	CDD:214631	203/643 (32%)
MCM6	NP_011314.2	MCM_N	112..205	CDD:405270	22/96 (23%)
		MCM	272..836	CDD:214631	201/619 (32%)
		MCM6_C	900..1007	CDD:408078	7/47 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810