Protein Alignment Mcm3 and MCM7

DIOPT Version :10

• Sequence 1: NP_511048.2
• Gene: Mcm3 / 31449
• FlyBaseID: FBgn0284442
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_009761.4
• Gene: MCM7 / 852501
• SGDID: S000000406
• Length: 845
• Species: Saccharomyces cerevisiae
• Alignment Length: 851
• Identity: 260/851 - (30%)
• Similarity: 388/851 - (45%)
• Gaps: 189/851 - (22%)

  Fly     3 HEGEQFIKDIQR------EYVDFLDDEEDQGIYAGHVKDMIAE----KSKRLIVNVNDLKRKNPQ 57
            |..|.|.:.|..      :.:|:.||          |.|:|..    :::|::.:     |.|..
Yeast   112 HFTELFCRAIDNNMPLPTKEIDYKDD----------VLDVILNQRRLRNERMLSD-----RTNEI 161

  Fly    58 RALGLLSNAADEQLAFGRALKEY----ASTVDPGYAKMHEDLFVGF----EGC--------FGNR 106
            |:..|:....|...:...||:|.    .....|...:.:   |:.|    :.|        ..::
Yeast   162 RSENLMDTTMDPPSSMNDALREVVEDETELFPPNLTRRY---FLYFKPLSQNCARRYRKKAISSK 223

  Fly   107 HVTPRSLTSIYLGNMVCVEGIVTKVSLIRPKVVRSVHYCPNT-----RKVMERKYTDL---TSFE 163
            .::.|.:...:||.::.|.||:|:||.::|.|....:.|...     ::|..|.:|.|   ||.|
Yeast   224 PLSVRQIKGDFLGQLITVRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEE 288

  Fly   164 AVPSGAAYPTKDEDGNLLETEYGLSVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKP 228
            .        ::::....|......|.:...|...|||:.::.|.|.:|||::|..:..||....|
Yeast   289 C--------SQNQTKGQLFMSTRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSP 345

  Fly   229 GDRVQIVGSYRCLPGKRGGY---TSGTFRTVLLANNISLLSKESNLDIS-----REDIMLCKKLA 285
            ||.|.:.|.:  ||....|:   .:|......|........|:.....|     .|.:|   :|.
Yeast   346 GDIVDVTGIF--LPAPYTGFKALKAGLLTETYLEAQFVRQHKKKFASFSLTSDVEERVM---ELI 405

  Fly   286 KNNDIFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTRLRGDINVLLIGDPSVAKSQLL 350
            .:.|::..|:||:||.|:|:..||:|:|.||:|||:|.:.:|.::||||||.|:|||.|||||||
Yeast   406 TSGDVYNRLAKSIAPEIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLL 470

  Fly   351 RYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRT 415
            :.:...:||.:.|||:|||||||||||..|..|.|..||.||:||||.|:.||||||||.:.|||
Yeast   471 KAICKISPRGVYTTGKGSSGVGLTAAVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRT 535

  Fly   416 AIHEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVM 480
            ||||||||..::||||||:.:||||.|:||||||:||||:...:|::||.|..:||||||:||:|
Yeast   536 AIHEVMEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLM 600

  Fly   481 LDVIDSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKDTEVYEKYDALL 545
            ||:...|.|:.:::||..:|.:....:.|..|:                |..|
Yeast   601 LDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPV----------------EPSK------------ 637

  Fly   546 HGKSRQRHEKILSVEFMRKYIHIAKCMKPKLGEQACEAIANEYSRLRSQEAVETDVART-QPITA 609
                            ||:||..||..:|.:.|...:.:...|.|||.....|.|...: ...|.
Yeast   638 ----------------MREYIAYAKTKRPVMSEAVNDYVVQAYIRLRQDSKREMDSKFSFGQATP 686

  Fly   610 RTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDKDRPSKRRRNSGSDAEDDNGE 674
            |||..:||||.|.|:.|::..|.|||...|:.||                  |.|......:..:
Yeast   687 RTLLGIIRLSQALAKLRLADMVDIDDVEEALRLV------------------RVSKESLYQETNK 733

  Fly   675 ASSQRSPSRRSKRTRTATVGADSDEEDIEPPQPDAG--DLTRRETRRSLPARSVAMLMASPSSEE 737
            :....||:     |:..|:        |:....:.|  .|:.....:::..|...||..|...:|
Yeast   734 SKEDESPT-----TKIFTI--------IKKMLQETGKNTLSYENIVKTVRLRGFTMLQLSNCIQE 785

  Fly   738 QSVATSTTEPAIISDARLGEFKNNLQRLFREA--------------REQSLA----LARITTA-I 783
            .|..                   |:..|..|.              :|.||.    ||..||| .
Yeast   786 YSYL-------------------NVWHLINEGNTLKFVDDGTMDTDQEDSLVSTPKLAPQTTASA 831

  Fly   784 NVGSQE 789
            ||.:|:
Yeast   832 NVSAQD 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	13..101	CDD:464206	18/105 (17%)
		MCM	106..648	CDD:214631	208/558 (37%)
MCM7	NP_009761.4	MCM_N	59..138	CDD:464206	7/35 (20%)
		MCM	223..724	CDD:214631	209/575 (36%)