Protein Alignment Mcm3 and MCM2

DIOPT Version :10

• Sequence 1: NP_511048.2
• Gene: Mcm3 / 31449
• FlyBaseID: FBgn0284442
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_009530.1
• Gene: MCM2 / 852258
• SGDID: S000000119
• Length: 868
• Species: Saccharomyces cerevisiae
• Alignment Length: 708
• Identity: 238/708 - (33%)
• Similarity: 366/708 - (51%)
• Gaps: 111/708 - (15%)

  Fly    10 KDIQREYVDFL---DDEEDQGIYAGHVKDMIAEKSKRLIVNVNDLKRKNPQRALGLLSNAADEQL 71
            :.|.||...||   .||..:.:|...::.:....|:.|.||...|.......|| .|:...:|.|
Yeast   205 RTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSESLEVNYRHLAESKAILAL-FLAKCPEEML 268

  Fly    72 -AFGRALKEYASTVDPGYAKMHEDLFVGFEGCFGNRHVTPRSLTSIY---------LGNMVCVEG 126
             .|.....|......|.||::|.::           ||......:||         |.::|.|.|
Yeast   269 KIFDLVAMEATELHYPDYARIHSEI-----------HVRISDFPTIYSLRELRESNLSSLVRVTG 322

  Fly   127 IVTKVSLIRPKVVRSVHYCPNTRKVMERKYTDLTSFEAVPSGAAYPTKDEDGNLLETEYGLS--- 188
            :||:.:.:.|::                ||   ..|..:..|:......:|.|   .|..:|
Yeast   323 VVTRRTGVFPQL----------------KY---VKFNCLKCGSILGPFFQDSN---EEIRISFCT 365

  Fly   189 ---------------VYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSY 238
                           ||:::|.:|:||.|...|.|:|||..:::...||||..|||:.|::.|.|
Yeast   366 NCKSKGPFRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKPGEEVEVTGIY 430

  Fly   239 R-----CLPGKRGGYTSGTFRTVLLANNISLLSKESN--------LDI---SREDIMLCKKLAKN 287
            :     .|..|.|   ...|.|::.||:|.  .:|.|        ||:   :.|:....:|::::
Yeast   431 KNNYDGNLNAKNG---FPVFATIIEANSIK--RREGNTANEGEEGLDVFSWTEEEEREFRKISRD 490

  Fly   288 NDIFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTRLRGDINVLLIGDPSVAKSQLLRY 352
            ..|.:.:..|:||||:||..:|.|:.|.|.|||.|.:.....:||||||||:|||..||||:|:|
Yeast   491 RGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVLLLGDPGTAKSQILKY 555

  Fly   353 VLNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAI 417
            |..||.||:..||:|:|.|||||:|..|..|.|..||.||:||||:||..|||||||:|.|||:|
Yeast   556 VEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSI 620

  Fly   418 HEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLD 482
            ||.|||..::||||||..:|.||||::|||||..|||:......:|:.|.:.:|||||:|.|:.|
Yeast   621 HEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNSTLPLAQNVSLTEPILSRFDILCVVRD 685

  Fly   483 VIDSDVDQMISDHVVRMH---RYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKDTEVYEKYDAL 544
            ::|.:.|:.::..||..|   ...|.::.:||.|....         .|:.|:.:.|:.|:.:|.
Yeast   686 LVDEEADERLATFVVDSHVRSHPENDEDREGEELKNNG---------ESAIEQGEDEINEQLNAR 741

  Fly   545 LHGKSRQR--HEKILSV--EFMRKYIHIAKC-MKPKLGEQACEAIANEYSRLRSQEAVETDVART 604
            .....|||  .|:|..:  |.:.||||.|:. :.|||.:...:.::..|:.|| :|::.|.   :
Yeast   742 QRRLQRQRKKEEEISPIPQELLMKYIHYARTKIYPKLHQMDMDKVSRVYADLR-RESISTG---S 802

  Fly   605 QPITARTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDKDRPSKRRR 662
            .|||.|.||:::|::.:.|:.|:|:.|:..|...||::|..::    :|..:.|.||:
Yeast   803 FPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKVVVDSF----VDAQKVSVRRQ 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	13..101	CDD:464206	23/91 (25%)
		MCM	106..648	CDD:214631	210/592 (35%)
MCM2	NP_009530.1	MCM2_N	49..193	CDD:403724
		MCM_N	209..299	CDD:464206	25/101 (25%)
		MCM	302..846	CDD:214631	208/587 (35%)