Protein Alignment Mcm3 and MCM5

DIOPT Version :9

• Sequence 1: NP_511048.2
• Gene: Mcm3 / 31449
• FlyBaseID: FBgn0284442
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_013376.1
• Gene: MCM5 / 850980
• SGDID: S000004264
• Length: 775
• Species: Saccharomyces cerevisiae
• Alignment Length: 707
• Identity: 234/707 - (33%)
• Similarity: 349/707 - (49%)
• Gaps: 110/707 - (15%)

  Fly     4 EGEQFIKDIQREYVDFLDDEEDQGIYAGHVKDMIAEKSKRLIVNVNDLKRKNPQRALGLLSNAAD 68
            :..:.||..:...::|..|  .|.||...:::.|..|:..|.||:..|...|......|....:|
Yeast    23 DNTEIIKSFKNFILEFRLD--SQFIYRDQLRNNILVKNYSLTVNMEHLIGYNEDIYKKLSDEPSD 85

  Fly    69 EQLAFGRALKEYASTV--------------DPGYAKMHED-LFVGFEGCF-----GNRHVTP-RS 112
            ....|..|:.:.|..:              ||....|..| |.:.....|     .|.:..| |.
Yeast    86 IIPLFETAITQVAKRISILSRAQSANNNDKDPENTSMDTDSLLLNSLPTFQLILNSNANQIPLRD 150

  Fly   113 LTSIYLGNMVCVEGIVTKVSLIRPKVVRSVHYCPNTRKVMERKYTDLTSFE----AVPSGAAYPT 173
            |.|.::..:|.:.||:...|::..:.......|.|.|........:..|..    ::|.......
Yeast   151 LDSEHVSKIVRLSGIIISTSVLSSRATYLSIMCRNCRHTTSITINNFNSITGNTVSLPRSCLSTI 215

  Fly   174 KDEDGNLLETEYG------------------LSVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDD 220
            :.|.....|:..|                  .|.:.|.|.|.:||:||..|.|::||::.:.||.
Yeast   216 ESESSMANESNIGDESTKKNCGPDPYIIIHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDR 280

  Fly   221 DLVDRCKPGDRVQIVGSYRCLPGKRG------GYTSGTFRTVLLANNISLLSKESNLDIS----- 274
            .|.::..||.||.|||.|.....|.|      |..:|.....:....|.:|..:|:::.|
Yeast   281 YLTNKVIPGTRVTIVGIYSIYNSKNGAGSGRSGGGNGGSGVAIRTPYIKILGIQSDVETSSIWNS 345

  Fly   275 -------REDIMLCKKLAKNNDIFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTRLRG 332
                   .|:..|  :|::|..::|:|:.|:||||.|:..:|:||:|||:||.:||||:|.||||
Yeast   346 VTMFTEEEEEEFL--QLSRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMRLRG 408

  Fly   333 DINVLLIGDPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLAD 397
            ||||||:|||..||||||::|...:|.|:.|:|:|||..||||:|..|..|.|..||.|||||||
Yeast   409 DINVLLLGDPGTAKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLAD 473

  Fly   398 RGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPME 462
            .|||||||||||.|.||.||||.|||..::|:||||...||:|.||||||||:|||||..|:|.:
Yeast   474 GGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGD 538

  Fly   463 NIGLQDSLLSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVS 527
            ||..|.::|||||::|::.|..:.:.|..|::||:.:|              .|::.|     :.
Yeast   539 NIDFQTTILSRFDMIFIVKDDHNEERDISIANHVINIH--------------TGNANA-----MQ 584

  Fly   528 SSEEKKDTEVYEKYDALLHGKSRQRHEKILSVEFMRKYIHIA--KCMKPKLGEQACEAIANEYSR 590
            :.:|:..:|:                    |:|.|::||...  || .|:|..||.|.:::.:..
Yeast   585 NQQEENGSEI--------------------SIEKMKRYITYCRLKC-APRLSPQAAEKLSSNFVT 628

  Fly   591 LRSQ---EAVETDVARTQPITARTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQ 644
            :|.|   ..:|:....:.|||.|.||.:||::.:.|:..:|..........||.|.|
Yeast   629 IRKQLLINELESTERSSIPITIRQLEAIIRITESLAKLELSPIAQERHVDEAIRLFQ 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	22/97 (23%)
		MCM	106..648	CDD:214631	208/585 (36%)
MCM5	NP_013376.1	MCM_N	29..>101	CDD:405270	18/73 (25%)
		MCM	144..689	CDD:214631	208/584 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810