DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm3 and MCM8

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001268450.1	Gene:	MCM8 / 84515	HGNCID:	16147	Length:	880	Species:	Homo sapiens

Alignment Length:	773	Identity:	210/773 - (27%)
Similarity:	343/773 - (44%)	Gaps:	167/773 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DIQRE---YVDFLDDEEDQGIYAGHVKDMIAEKSKRLIVNVNDLKRKNPQRALGLLSNAADEQLA 72
            :|:|:   .|||.:..|     .|.|.::|.:.:..|        |..|::.|..:..|..:.|.
Human   114 EIERKGSILVDFKELTE-----GGEVTNLIPDIATEL--------RDAPEKTLACMGLAIHQVLT 165

  Fly    73 FGRALKEYASTVDPGYAKMHEDLFVGFEGCFGNRHVTPR-----SLTSI------YLGNMVCVEG 126
              :.|:.:|:.:     :..|.|....|......|:..|     .||.:      |.|..:.:.|
Human   166 --KDLERHAAEL-----QAQEGLSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRG 223

  Fly   127 IVTKVSLIRPKVVRSVHYCPNTRKVM-----ERKYTDLT----------SFEAVPSGAAYPTKDE 176
            .|.:||.|:|...:....|....::.     :.||:..|          ||.|:.|..
Human   224 TVVRVSNIKPLCTKMAFLCAACGEIQSFPLPDGKYSLPTKCPVPVCRGRSFTALRSSP------- 281

  Fly   177 DGNLLETEYGLSVYKDHQTLTIQEM--PEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSYR 239
                      |:|..|.|::.|||:  .::..||::||:::.....||||.|.|||.|.|.|..:
Human   282 ----------LTVTMDWQSIKIQELMSDDQREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVK 336

  Fly   240 CLPGKRGGYTSG---TFRTVLLANNIS------LLSKESN------LDISREDIMLCKKLAKNND 289
            ....:.|.....   .|...:.||:||      ..|.|..      ::.|.:|:...:::....:
Human   337 VSNAEEGSRNKNDKCMFLLYIEANSISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEEN 401

  Fly   290 IFELLSK---SLAP------SIHGHA-------------------------------YVKQAILC 314
            :|:|:.|   :|:|      :|..|.                               .||..:..
Human   402 LFKLIVKWSLALSPRLEYSGAISAHCNLHLPSSNSSPTSACRVAGTTGMRHQTQLLLLVKAGLAL 466

  Fly   315 LLLGGVEKILPNGTR--LRGDINVLLIGDPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAAV 377
            .|.||.:|...:..|  :|||.::|::|||.:.|||:|:...|.|||.:...|..::..|||..:
Human   467 ALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGNTTTTSGLTVTL 531

  Fly   378 TTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARCS 442
            :.|..:|:..|||||:||.|:|:..|||||||.: ...|:.|.|||..::::|||:..||.||.|
Human   532 SKDSSSGDFALEAGALVLGDQGICGIDEFDKMGN-QHQALLEAMEQQSISLAKAGVVCSLPARTS 595

  Fly   443 VLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVIDSDVDQMISDHV--VRMHRYRNP 505
            ::||||||.|.|::.||..||:.:..:|||||||:|::||..:...|.::|:||  :|..:.|..
Human   596 IIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAGKQRTI 660

  Fly   506 KEADGEPLSMGSSYADSLSFVSSSEEKKDTEVY--EKYDALLHGKSRQRHEKILSVEFMRKYIHI 568
            ..|....::...|....|..||.....:..:|.  |..|.:.|             :.:||||..
Human   661 SSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDPIPH-------------QLLRKYIGY 712

  Fly   569 AK-CMKPKLGEQACEAIANEYSRLRSQEAVETDVARTQPITARTLETLIRLSTAHARARMSKSVT 632
            |: .:.|:|..:|...:.:.|..||.|    :....:.|||.|.||:||||:.|.||..:.:..|
Human   713 ARQYVYPRLSTEAARVLQDFYLELRKQ----SQRLNSSPITTRQLESLIRLTEARARLELREEAT 773

  Fly   633 IDDAHAAIELVQFAYFKKV------LDKDRPSKRRRNSGSDAEDDNGEASSQRSPSRR 684
            .:||...:|:::::.....      ||.:|             ..:|...|.||.::|
Human   774 KEDAEDIVEIMKYSMLGTYSDEFGNLDFER-------------SQHGSGMSNRSTAKR 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	16/82 (20%)
Mcm3	NP_511048.2	MCM	106..648	CDD:214631	182/631 (29%)
MCM8	NP_001268450.1	MCM_N	98..223	CDD:291233	26/128 (20%)
		Mcm2	139..877	CDD:224162	201/743 (27%)
		AAA	475..633	CDD:99707	71/158 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820