DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm3 and MCM6

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001331629.1	Gene:	MCM6 / 834492	AraportID:	AT5G44635	Length:	857	Species:	Arabidopsis thaliana

Alignment Length:	847	Identity:	248/847 - (29%)
Similarity:	392/847 - (46%)	Gaps:	192/847 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EQFIKDIQREYVDF-----LDDEEDQGIYAGHVKDMIAEKSKRLIVNVNDLKRKNP--QRALGLL 63
            ||.|: ::..:::|     ||..:.:..|...::.:...:|..:.::.:.:...|.  |:|:
plant    11 EQAIQ-VENVFLEFLKSFRLDANKPELYYEAEIEAIRGGESTMMYIDFSHVMGFNDALQKAI--- 71

  Fly    64 SNAADEQLAF----GRALKEYASTVDPGYAK---MHEDLFVGFEGCFGNRHVTPRSLTSIYLGNM 121
               |||.|.|    ..|.|.:...::|.:..   .::|:.|.|......:.:  |.||:..:|.:
plant    72 ---ADEYLRFEPYLRNACKRFVIEMNPSFISDDTPNKDINVSFYNLPFTKRL--RELTTAEIGKL 131

  Fly   122 VCVEGIVTKVSLIRPKVVRSVHYCPNTRKVMER-----KYTDLTSFEAVPSGAAYPT--KDEDGN 179
            |.|.|:||:.|.:||:::.....|.:...|::.     |||.       |:....||  ......
plant   132 VSVTGVVTRTSEVRPELLYGTFKCLDCGSVIKNVEQQFKYTQ-------PTICVSPTCLNRARWA 189

  Fly   180 LLETEYGLSVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVG-------- 236
            ||..|   |.:.|.|.:.:||..::.|||.||||:|::...::|::.:.||.|...|
plant   190 LLRQE---SKFADWQRVRMQETSKEIPAGSLPRSLDVILRHEIVEQARAGDTVIFTGTVVVIPDI 251

  Fly   237 SYRCLPGKRG----------GYTSG---------------TFRTVLLANNISLLSKESNLDI--- 273
            |....||:|.          ..|:|               ::|...:||::.:.....|.|:
plant   252 SALAAPGERAECRRDSSQQKSSTAGHEGVQGLKALGVRDLSYRLAFIANSVQIADGSRNTDMRNR 316

  Fly   274 ------------SREDIMLCKKLAKNNDIFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPN 326
                        :.|::...:::....|.|..|..|:||::.||..:|:|:|.:|||||.|....
plant   317 QNDSNEDDQQQFTAEELDEIQQMRNTPDYFNKLVGSMAPTVFGHQDIKRAVLLMLLGGVHKTTHE 381

  Fly   327 GTRLRGDINVLLIGDPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAG 391
            |..|||||||.::||||.||||.|:|.....||::.|:|:.||..||||.|..:.||||..:|||
plant   382 GINLRGDINVCIVGDPSCAKSQFLKYTAGIVPRSVYTSGKSSSAAGLTATVAKEPETGEFCIEAG 446

  Fly   392 AMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQ 456
            |::|||.|:.||||||||...|:.||||.|||..::|:||||.|:||||.|:|||||||.||||:
plant   447 ALMLADNGICCIDEFDKMDIKDQVAIHEAMEQQTISITKAGIQATLNARTSILAAANPVGGRYDK 511

  Fly   457 YKTPMENIGLQDSLLSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYAD 521
            .|....|:.|..::||||||::||:|..|...|..|:.|:||:|
plant   512 SKPLKYNVNLPPAILSRFDLVYVMIDDPDEVTDYHIAHHIVRVH--------------------- 555

  Fly   522 SLSFVSSSEEKKDTEVYEKYDALLHGKSRQRHEKILSVEF----MRKYIHIAKCMKPKLGEQACE 582
                                         |:||..||.||    :::||..||.:||||..:|.:
plant   556 -----------------------------QKHEAALSPEFTTVQLKRYIAYAKTLKPKLSPEARK 591

  Fly   583 AIANEYSRLRSQEAVE-TDVARTQPITARTLETLIRLSTAHARARMSKSVTIDDAHA--AIELVQ 644
            .:...|..||..:... |.||  ..:|.|.||.|||||.|.||:.:  .:.:..:|.  |:.|::
plant   592 LLVESYVALRRGDTTPGTRVA--YRMTVRQLEALIRLSEAIARSHL--EILVKPSHVLLAVRLLK 652

  Fly   645 FAYFKKVLDKDRPSKRRRNSG----SDAEDDNGEASSQRSPSRRSKRTRTATVGADSDEEDIEPP 705
            .:....            .||    |:.:|.||:..                    .|.:|||.|
plant   653 TSVISV------------ESGDIDLSEYQDANGDNM--------------------DDTDDIENP 685

  Fly   706 QPDAGDLTRRETRRSLPARSVAMLMASPSSEEQSVATSTTEPAIISDARLGEFKNNLQRLFREAR 770
            .....|   ::...:.||.:.    |...:..|.:..|..|...|:.|.:...:.:.:.:.::::
plant   686 VDGEED---QQNGAAEPASAT----ADNGAAAQKLVISEEEYDRITQALVIRLRQHEETVNKDSK 743

  Fly   771 EQ 772
            :|
plant   744 QQ 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	19/96 (20%)
Mcm3	NP_511048.2	MCM	106..648	CDD:214631	205/603 (34%)
MCM6	NP_001331629.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266497at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820