DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm3 and PRL

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001190655.1	Gene:	PRL / 828153	AraportID:	AT4G02060	Length:	716	Species:	Arabidopsis thaliana

Alignment Length:	732	Identity:	241/732 - (32%)
Similarity:	369/732 - (50%)	Gaps:	110/732 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KDIQREYVDFLDDEEDQGIYAGHVKDMIAEKSKRLIVNVNDL-------------KRKNPQRALG 61
            |.:.:.:::...|...:..|...::::...|.:.:.|:::||             ..:|.:|.:.
plant    10 KGLAKGFLENFADANGRSKYMEILQEVSNRKIRAIQVDLDDLFNYKDESEEFLGRLTENTRRYVS 74

  Fly    62 LLSNAADEQL-----AFG-------RALKEYASTVDPGYAKMHEDL--------FVGFEGCFGNR 106
            :.|.|.||.|     ||.       ...:....|.:|..:..|:.:        .|.|:.....|
plant    75 IFSAAVDELLPEPTEAFPDDDHDILMTQRADDGTDNPDVSDPHQQIPSEIKRYYEVYFKAPSKGR 139

  Fly   107 HVTPRSLTSIYLGNMVCVEGIVTKVSLIRPKVVRSVHYCPNTRKVMERKYTDLTS------FEAV 165
            ..|.|.:.:.::|.:|.:.||||:.|.::|.:..:|:.|.:....:   |.::||      |:..
plant   140 PSTIREVKASHIGQLVRISGIVTRCSDVKPLMAVAVYTCEDCGHEI---YQEVTSRVFMPLFKCP 201

  Fly   166 PSGAAYPTKDEDGNLLETEYGLSVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGD 230
            .|.....:|  .||.: .:...|.:...|...:||:.|..|.|.:|||:.:....:|..:..|||
plant   202 SSRCRLNSK--AGNPI-LQLRASKFLKFQEAKMQELAEHVPKGHIPRSMTVHLRGELTRKVSPGD 263

  Fly   231 RVQIVGSYRCLP-----GKRGGYTSGTFRTVLLANNISLLSKE-SNLDISREDIMLCKKLAKNND 289
            .|:..|.:..:|     ..|.|..:.|:   |.|.:::...|: ...:..:::.....:||::.|
plant   264 VVEFSGIFLPIPYTGFKALRAGLVADTY---LEATSVTHFKKKYEEYEFQKDEEEQIARLAEDGD 325

  Fly   290 IFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTRLRGDINVLLIGDPSVAKSQLLRYVL 354
            |:..||:||||.|:||..:|:|:|.||:|...:.|.:|.::|||:::.|:|||.|||||||::::
plant   326 IYNKLSRSLAPEIYGHEDIKKALLLLLVGAPHRQLKDGMKIRGDVHICLMGDPGVAKSQLLKHII 390

  Fly   355 NTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHE 419
            |.|||.:.|||:|||||||||||..||.|.|..||.||:||||.|:..|||||||.:.|||||||
plant   391 NVAPRGVYTTGKGSSGVGLTAAVMRDQVTNEMVLEGGALVLADMGICAIDEFDKMDESDRTAIHE 455

  Fly   420 VMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVI 484
            ||||..|:|:||||..|||||.:|||||||.:||||..:||.|||.|..:||||||||:::||..
plant   456 VMEQQTVSIAKAGITTSLNARTAVLAAANPAWGRYDLRRTPAENINLPPALLSRFDLLWLILDRA 520

  Fly   485 DSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKDTEVYEKYDALLHGKS 549
            |.|.|..::.||:.:|:.........||
plant   521 DMDSDLELAKHVLHVHQTEESPALGFEP------------------------------------- 548

  Fly   550 RQRHEKILSVEFMRKYIHIAKCMKPKLGEQACEAIANEYSRLRSQEA-VETDVARTQPITARTLE 613
                   |....:|.||..|:.:.|.:..:..|.||..||.:|.:|| ..|..:.|   |.|||.
plant   549 -------LEPNILRAYISAARRLSPYVPAELEEYIATAYSSIRQEEAKSNTPHSYT---TVRTLL 603

  Fly   614 TLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDKDRPSKRRRNSGSDAEDDNGEASSQ 678
            :::|:|.|.||.|.|:||...|...|:.|:|.:......|.      |:.:|.||..|.  .|..
plant   604 SILRISAALARLRFSESVAQSDVDEALRLMQMSKISLYADD------RQKAGLDAISDT--YSII 660

  Fly   679 RSPSRRSKRTRTATVGA 695
            |..:.|||:|..:...|
plant   661 RDEAARSKKTHVSYANA 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	20/115 (17%)
Mcm3	NP_511048.2	MCM	106..648	CDD:214631	207/554 (37%)
PRL	NP_001190655.1	MCM_N	16..98	CDD:405270	15/81 (19%)
PRL	NP_001190655.1	MCM	139..638	CDD:214631	207/554 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266497at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820