DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm3 and MCM9

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001318221.1	Gene:	MCM9 / 815890	AraportID:	AT2G14050	Length:	651	Species:	Arabidopsis thaliana

Alignment Length:	735	Identity:	206/735 - (28%)
Similarity:	313/735 - (42%)	Gaps:	200/735 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EYVDFLDDE------------------EDQGIYA-----GHVKDMIAEK---SKRLI-VNVNDLK 52
            ||.:.:||.                  :|..|.|     .|:| ...||   .||.| |.:|  .
plant    44 EYAELVDDNPSLARQVFSDPEHYLRQFDDSAILAHKIALEHMK-KFEEKIGIEKRFIHVRIN--T 105

  Fly    53 RKNPQRALGLLSNAADEQLAFGRALKEY--------ASTVDPGYAKMHEDLFVGFEG-----CFG 104
            ..:|      |..:.:...:.||...::        .:.:..|..||       :||     |..
plant   106 SGSP------LERSPETFPSIGRVRVKHRGILMMLKGTVIRSGAVKM-------YEGEKMYRCRK 157

  Fly   105 NRHVTP--RSLTSIYLGNMVCVEGIVTKVSLIRPKVVRSVHYCPNTRKVMERKYTDLTSFEAVPS 167
            .:|:.|  ..|.||.              |:::|.      :||:.|.    |..:.|:|:.|
plant   158 CKHMFPIFPELESIN--------------SIVKPP------FCPSQRS----KACEGTNFDPV-- 196

  Fly   168 GAAYPTKDEDGNLLETEYGLSVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRV 232
                     |..:..        .|:|.:.|||..:....|.:|||:.:|..|||||..|.||.|
plant   197 ---------DDTVTR--------HDYQEIKIQENTQVLGVGVIPRSILVVLKDDLVDNVKAGDDV 244

  Fly   233 QIVG-----------SYRCLPGKRGGYTSGTFRTVLLANNISLLSK-ESNLDISREDIMLCKK-- 283
            .:.|           ..||           ....:|:||::...:: :|.:|||.:.|...|.
plant   245 VVSGILTSKWSHDLKDVRC-----------DLEPMLIANHVRRTNELKSEIDISDDLIEKFKNFW 298

  Fly   284 -------LAKNNDIFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTRLRGDINVLLIGD 341
                   |...|.|.    :.:.|.:.|...||.|:...|:|||:.:..:||::||:.::|||||
plant   299 SHFRDTPLKGRNAIL----RGICPQVFGLFTVKLAVALTLIGGVQHVDASGTKVRGESHLLLIGD 359

  Fly   342 PSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEF 406
            |...|||.|::....:.||:.|||.||:..|||  ||..::.||..|||||:||||.|:.|||||
plant   360 PGTGKSQFLKFAAKLSNRAVITTGLGSTSAGLT--VTAVKDGGEWMLEAGALVLADGGLCCIDEF 422

  Fly   407 DKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLL 471
            |.|.:.||..|||.|||..::::|||:..:|:.:..|..|.|| .|:||..::...|..|...||
plant   423 DSMREHDRATIHEAMEQQSISVAKAGLVTTLSTKTIVFGATNP-KGQYDPDQSLSVNTALSGPLL 486

  Fly   472 SRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPKEADG----EPLSMGSSYADSLSFVSSSEEK 532
            ||||::.|:||..:.:.|.::|.|::...:....:|.|.    .||.|
plant   487 SRFDIVLVLLDTKNPEWDAVVSSHILAEVQIEQDREVDDLTTIWPLPM----------------- 534

  Fly   533 KDTEVYEKYDALLHGKSRQRHEKILSVEFMRKYIH-IAKCMKPKLGEQACEAIANEYSRLRSQEA 596
                                         :::||. :.|..:|.|.::| |.|.:.|.||:.:.:
plant   535 -----------------------------LQRYIQFVKKNFRPVLSKEA-EEIISSYYRLQRRSS 569

  Fly   597 VETDVARTQPITARTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAY-FKKVLDKDRPSKR 660
            .. :.|||   |.|.||:||||:.||||......||..||..||..::.:. ...::|.   ...
plant   570 TH-NAART---TVRMLESLIRLAQAHARLMFRNEVTRLDAITAILCIESSMTISAIVDS---MGN 627

  Fly   661 RRNSGSDAEDDNGEASSQRS 680
            ..:|....|.|...|..:||
plant   628 ALHSNFSEEPDQEYAKQERS 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	21/117 (18%)
Mcm3	NP_511048.2	MCM	106..648	CDD:214631	173/570 (30%)
MCM9	NP_001318221.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266497at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820