DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm3 and MCM5

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_178812.1	Gene:	MCM5 / 815415	AraportID:	AT2G07690	Length:	727	Species:	Arabidopsis thaliana

Alignment Length:	779	Identity:	252/779 - (32%)
Similarity:	367/779 - (47%)	Gaps:	131/779 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 REYVDFLDDEEDQGIYAGHVKDMIAEKSKRLIVNVNDLK----------RKNPQRALGLLSNAAD 68
            :|::...:.|::...|    ::.:.:..|||:|::.||.          |..|...|.:...||.
plant    36 KEFIRNFEIEQNCFPY----REALLDNPKRLVVHLEDLLSFDSDLPSLIRSAPADYLPVFEKAAG 96

  Fly    69 EQLAFGRALKEYASTVDPGYAKMHEDLFVGFEGCFGNRH--VTPRSLTSIYLGNMVCVEGIVTKV 131
            |.|. |..::|    .:.| ..|.|.|....:....:|.  |:.|.|.:.|:..:|.:.||....
plant    97 EVLT-GLKMRE----ANEG-GVMEEPLTRDVQILLTSREDPVSMRLLGAQYISKLVKISGISIAA 155

  Fly   132 SLIRPKVVRSVHYCPNTRKVMERKYTDLTSFEAVP-----SGAAYPTKDE------------DGN 179
            |.::.|.......|.|.:|..|           ||     .||..|...:            |..
plant   156 SRVKAKATYVFLVCKNCKKTRE-----------VPCRPGLGGAIVPRSCDNIPQPGEEPCPLDPW 209

  Fly   180 LLETEYGLSVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSYRCLPGK 244
            ::..:  .|.|.|.|||.:||.||..|.|:|||::.:..|..||....||.|:.::|.|......
plant   210 MVVPD--RSQYVDQQTLKLQENPEDVPTGELPRNMLLSVDRHLVQTIVPGTRLTVMGIYSIFQAS 272

  Fly   245 RGGYT-SGT-------FRTVLLANNISLLSK-ESNLDISREDIMLCKKLAKNNDIFELLSKSLAP 300
            ....: .|.       .|.|.|.:.....|: .:|.....|:..  ||.|.:.|:::.:...:||
plant   273 SSSNSHKGAVAIRQPYIRVVGLEDTNEASSRGPANFTPDEEEEF--KKFADSQDVYKNICTKIAP 335

  Fly   301 SIHGHAYVKQAILCLLLGGVEKILPNGTRLRGDINVLLIGDPSVAKSQLLRYVLNTAPRAIPTTG 365
            ||.||..||:|..|||.||..|.||:|.:|||||||||:||||.||||.|::|..|||.|:.|:|
plant   336 SIFGHEDVKRAAACLLFGGSRKSLPDGVKLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSG 400

  Fly   366 RGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISK 430
            :|||..||||:|..|..|.|..||.|||||||.|||||||||||...||.||||.|||..::|:|
plant   401 KGSSAAGLTASVIRDSSTREFYLEGGAMVLADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAK 465

  Fly   431 AGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVIDSDVDQMISDH 495
            |||...||:|.||||||||..||||..||..:||.||.::||||||:|::.|:.....|:.|:.|
plant   466 AGITTVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDIRKYSQDKEIASH 530

  Fly   496 VVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKDTEVYEKYDALLHGKSRQRHEKILSVE 560
            ::|:|...|             .::|     .:::.|:|                         .
plant   531 IIRVHASAN-------------KFSD-----ENTDSKED-------------------------N 552

  Fly   561 FMRKYIHI--AKCMKPKLGEQACEAIANEYSRLR---SQEAVETDVARTQPITARTLETLIRLST 620
            ::::||..  |:| .|:|.:.|.|.:..:|..:|   .:.|.||..|...|||.|.||.::|||.
plant   553 WLKRYIQYCRARC-HPRLSKDAAENLQRKYVTIRMDMKRRAHETGEAAPIPITVRQLEAIVRLSE 616

  Fly   621 AHARARMSKSVTIDDAHAAIELVQFAYFKKVLDKDRPSKRRRNSGSDAE-DDNGEASSQRSPSRR 684
            :.|:.|:|...|.||...|.:|    :....:|..|       ||.:.: :..||.:::...:..
plant   617 SLAKMRLSHEATPDDVDKAFKL----FDTSTMDAAR-------SGINQQINITGEMANEIKQAET 670

  Fly   685 SKRTRTATVGADSDEEDIEPPQPDAGDLTRRETRRSLPARSVAMLMASPSSEEQSVATSTTEPA 748
            ..:.|.......|:...||       ||.|.....|:..|::.::......|.|....|....|
plant   671 QIKRRMGIGARLSERRLIE-------DLARMGMNDSMVRRALLIMHQRGEVEYQRERRSIVRKA 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	21/92 (23%)
Mcm3	NP_511048.2	MCM	106..648	CDD:214631	211/574 (37%)
MCM5	NP_178812.1	MCM_N	35..127	CDD:379644	22/100 (22%)
MCM5	NP_178812.1	MCM	131..644	CDD:214631	210/575 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266497at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820