DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm3 and mcm8

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001072344.1	Gene:	mcm8 / 779797	XenbaseID:	XB-GENE-961372	Length:	843	Species:	Xenopus tropicalis

Alignment Length:	727	Identity:	212/727 - (29%)
Similarity:	353/727 - (48%)	Gaps:	102/727 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FIKDIQREYVDFLDDEEDQGIYAGHVKDMIAEKSKRLIVNVNDLKRKNPQRALGLLSNAADEQLA 72
            |.|.|  |..| .|:.|.:|......||::.::.....:.::...::.|::.|..:..|..:.|.
Frog    95 FTKQI--ELYD-KDEIERKGSILVDYKDLLQDEDLSASIPMSSELKEMPEKILECMGLAIHQVLT 156

  Fly    73 FGRALKEYASTVDPGYAKMHEDLFVGFEG-----------------CFGNRHVTP-RSLTSIYLG 119
              :.|:.:|       |::.|.     ||                 .|....:|| ::|.:...|
Frog   157 --KDLERHA-------AELQEQ-----EGLRTEEAPIVNVPFIHARVFNYDPLTPLKNLRASLYG 207

  Fly   120 NMVCVEGIVTKVSLIRPKVVRSVHYCPNTRKVMERKYTDLTSFE------AVPSGAAYPTKDEDG 178
            ..|.:.|.|.:||.|:|..|:....|        ....|:.||.      |||:....|......
Frog   208 KYVALRGTVVRVSNIKPLCVKMAFSC--------NMCGDIQSFPFPDGKYAVPTKCPVPECRGRS 264

  Fly   179 NLLETEYGLSVYKDHQTLTIQEM--PEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSYRCL 241
            ........|:|..|.||:.:||:  .::..||::||:|:.....||||.|.|||.|.:.|..:..
Frog   265 FTANRSSPLTVTVDWQTIKVQELMSDDQREAGRIPRTVECELIQDLVDSCVPGDMVTVTGIVKVS 329

  Fly   242 PGKRGGYTSGTFRTVLL----ANNIS------------LLSKESNLDISREDIMLCKKLAKNNDI 290
            ..:.||:.:...:.:.|    ||::|            ..|..:::|.|.:|:...:::....::
Frog   330 NTRDGGFKNKNNKCMFLLYIEANSVSNSKGHKIKSTDDSESHGASMDFSLKDLYAIQEIQAQENL 394

  Fly   291 FELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTR--LRGDINVLLIGDPSVAKSQLLRYV 353
            |:|:..||.|:|:||..||..:...|.||.:|...:..|  :|||.::|::|||.:.|||:|:.|
Frog   395 FQLIVNSLCPTIYGHELVKAGLSLALFGGCQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAV 459

  Fly   354 LNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIH 418
            .|.|||.:...|..::..|||..::.|..||:..|||||::|.|:|:..|||||||.: ...|:.
Frog   460 CNVAPRGVYVCGNTTTTSGLTVTLSRDSATGDFGLEAGALILGDQGICGIDEFDKMGN-QHQALL 523

  Fly   419 EVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDV 483
            |.|||..::::||||..||.||.|::||||||.|.|::.||..||:.:..:|||||||:|::||.
Frog   524 EAMEQQSISLAKAGIVCSLPARTSIIAAANPVGGHYNKGKTVSENLKMGSALLSRFDLVFILLDT 588

  Fly   484 IDSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKDTEVY-----EKYDA 543
            .:.|.|.::|:||:.|.  ...||.....|:..::...:.|.:....|:...|..     |.:|.
Frog   589 PNEDHDHLLSEHVMAMR--AGAKEMQSADLTCPTTQNSNTSVLEEPSERPLGERLKLRPGEHFDP 651

  Fly   544 LLHGKSRQRHEKILSVEFMRKYIHIAKCMKPKLGEQACEAIANEYSRLRSQ-EAVETDVARTQPI 607
            :.|...|:      .|.:.|:|:|      |.|...|.:.:.:.|..||.| :.::     :.||
Frog   652 IPHQLLRK------YVGYARQYVH------PTLSPDAAQVLQDFYLELRKQNQGID-----STPI 699

  Fly   608 TARTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDKDRPSKRRRNSGSDAEDDN 672
            |.|.||:||||:.|.||..:.:..|.|||...:::::::......|:.......|:       .:
Frog   700 TTRQLESLIRLTEARARLELREKATKDDAEEVVQIMKYSLLGTFSDEFGKLDFHRS-------QH 757

  Fly   673 GEASSQRSPSRR 684
            |...|.||.:::
Frog   758 GSGMSNRSKAKK 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	14/82 (17%)
Mcm3	NP_511048.2	MCM	106..648	CDD:214631	185/574 (32%)
mcm8	NP_001072344.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		Mcm2	93..769	CDD:224162	212/725 (29%)
		MCM8	397..738	CDD:350665	132/360 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920