DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm3 and Mcm8

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001277983.1	Gene:	Mcm8 / 66634	MGIID:	1913884	Length:	833	Species:	Mus musculus

Alignment Length:	731	Identity:	212/731 - (29%)
Similarity:	349/731 - (47%)	Gaps:	98/731 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FIKDIQ------REYVDFLD-DE-EDQGIYAGHVKDMI-AEKSKRLIVNVNDLKRKNPQRALGLL 63
            ||:.||      ..::|..| || |.:|......|::. |::...||.::.:..|..|::.|..:
Mouse    85 FIEKIQAFEKFFTRHIDLYDKDEIERKGSILVDFKELTKADEITNLIPDIENALRDAPEKTLACM 149

  Fly    64 SNAADEQLAFGRALKEYASTVDPGYAKMHEDLFVGFEGCFGNRHVTPR-----------SLTSIY 117
            ..|..:.|.  :.|:.:|:.:     :..|.|..|.|......|:..|           ::.:..
Mouse   150 GLAIHQVLT--KDLERHAAEL-----QAQEGLSNGGETMVNVPHIYARVYNYEPLTHLKNIRATC 207

  Fly   118 LGNMVCVEGIVTKVSLIRPKVVRSVHYCPNTRKVM-----ERKYTDLTSFEAVPS--GAAY-PTK 174
            .|..:.:.|.|.:||.|:|........|....::.     :.||| |.:...||:  |.:: |.:
Mouse   208 YGKYISIRGTVVRVSNIKPLCTNMAFQCAACGEIQSFPLPDGKYT-LPTKCPVPACRGRSFAPLR 271

  Fly   175 DEDGNLLETEYGLSVYKDHQTLTIQEMPEKA--PAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGS 237
            ...         |:|..|.|.:.|||:...|  .||::||:::.....||||.|.|||.|.:.|.
Mouse   272 SSP---------LTVTLDWQLIKIQELMSDAQREAGRIPRTIECELVHDLVDSCVPGDTVTVTGI 327

  Fly   238 YRCLPGKRGGYTSG---TFRTVLLANNIS------LLSKESN------LDISREDIMLCKKLAKN 287
            .:....:.|.....   .|...:.||::|      ..:.|..      ::.|.:|:...:::...
Mouse   328 VKVSNSEEGSRNKNDKCMFLLYIEANSVSNSKGPKAQTAEDGCKHGTLMEFSLKDLYAIREIQAE 392

  Fly   288 NDIFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTR--LRGDINVLLIGDPSVAKSQLL 350
            .::.:|:..||.|.|.||..||..:...|.||.:|...:..|  :|||.:||::|||.:.|||:|
Mouse   393 ENLLKLVVNSLCPVIFGHELVKAGLTLALFGGSQKYADDKNRIPIRGDPHVLIVGDPGLGKSQML 457

  Fly   351 RYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRT 415
            :...|.|||.:...|..::..|||..::.|..:|:..|||||:||.|:|:..|||||||.: ...
Mouse   458 QAACNVAPRGVYVCGNTTTSSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGN-QHQ 521

  Fly   416 AIHEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVM 480
            |:.|.|||..::::|||:..||.||.|::||||||.|.|::.:|..||:.:..:|||||||:|::
Mouse   522 ALLEAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKARTVSENLKMGSALLSRFDLVFIL 586

  Fly   481 LDVIDSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKDTEVY-----EK 540
            ||..:...|.::|:||:.: |....|......::...|...:.|.:....||..:|..     |:
Mouse   587 LDTPNEQHDHLLSEHVIAI-RAGKQKAVSSATVTRVLSQDSNTSVLEVVSEKPLSERLKVAPGEQ 650

  Fly   541 YDALLHGKSRQRHEKILSVEFMRKYIHIAK-CMKPKLGEQACEAIANEYSRLRSQEAVETDVART 604
            .|.:.|             :.:||||..|: .:.|:|...|.:|:.:.|..||.|    :....:
Mouse   651 TDPIPH-------------QLLRKYIGYARQYVHPRLSTDAAQALQDFYLELRKQ----SQRVGS 698

  Fly   605 QPITARTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDKDRPSKRRRNSGSDAE 669
            .|||.|.||:||||:.|.||..:.:..|.:||...||:::.:......|:        ....|.|
Mouse   699 SPITTRQLESLIRLTEARARLELREEATREDAEDIIEIMKHSMLGTYSDE--------FGNLDFE 755

  Fly   670 -DDNGEASSQRSPSRR 684
             ..:|...|.||.::|
Mouse   756 RSQHGSGMSNRSTAKR 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	20/85 (24%)
Mcm3	NP_511048.2	MCM	106..648	CDD:214631	179/585 (31%)
Mcm8	NP_001277983.1	MCM_N	91..216	CDD:291233	24/131 (18%)
		Mcm2	132..830	CDD:224162	198/684 (29%)
		AAA	428..586	CDD:99707	71/158 (45%)
		PEPcase	<676..>747	CDD:304407	24/74 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820