DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm3 and mcm6

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001076318.1	Gene:	mcm6 / 566409	ZFINID:	ZDB-GENE-030909-6	Length:	830	Species:	Danio rerio

Alignment Length:	738	Identity:	220/738 - (29%)
Similarity:	356/738 - (48%)	Gaps:	145/738 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QFIKD-----IQREYVDFLDDEEDQGIYAGHVK------DMIAEKSKRLIVNVNDLKRKNPQRAL 60
            |.|||     .|:.:..||::.::..   |.||      ::|..:...|.|:..||:..|.:
Zfish    14 QVIKDELAEKCQKLFQAFLEEFQNSD---GEVKYLRDAEELIRPERNTLAVSFTDLEGFNQE--- 72

  Fly    61 GLLSNAADEQL-----AFGRALKEYASTVDPGYAKMHEDLFVGFEGCFGNRHVTPRSLTSIYLGN 120
              |:.|..|:.     ...||::.:|.  :.|.....::.:|.|:. ...||.. |.||::.:|:
Zfish    73 --LATAIQEEFYRLYPYLCRAVRNFAR--EHGEVPTSKEFYVAFQD-LPTRHKI-RELTTVKVGS 131

  Fly   121 MVCVEGIVTKVSLIRPKVVRSVHYCPNTRKVM-----ERKYTDLTSFEAVPSGAAYPT-KDEDGN 179
            :|.:.|.|.:...:.|::|.....|.:.:.|:     :.|||.       ||....|. .:....
Zfish   132 LVRISGQVVRTHPVHPELVSGTFLCLDCQGVIKDVEQQFKYTQ-------PSICRNPVCNNRRRF 189

  Fly   180 LLETEYGLSVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSYRCLP-- 242
            ||:|  ..|.:.|.|.|.|||...:.|.|.:|||::::...:.|:..:.||:...:||...:|
Zfish   190 LLDT--NKSKFIDFQKLRIQETQAELPRGSIPRSMEVILRAEAVESAQAGDKCDFIGSLIVVPDI 252

  Fly   243 -------------------------GKRG----GYTSGTFRTVLLANNIS----------LLSKE 268
                                     |.||    |....:::...||.:::          :..:|
Zfish   253 SQLATPGVRAETSSRTAGVQGYENEGLRGLKALGVRELSYKLAFLACHVAPTNPRFGGKEIRDEE 317

  Fly   269 SNLDISREDIMLCK-----KLAKNNDIFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGT 328
            ...:..::.:.:.:     :::::.:::..|..||.|:|||:..||:.||.:|.|||.|....||
Zfish   318 QTAESIKKQMSVQEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGILLMLFGGVPKTTMEGT 382

  Fly   329 RLRGDINVLLIGDPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAM 393
            .|||||||.::||||.||||.|::|....|||:.|:|:.||..||||||..|:|:.|..:||||:
Zfish   383 SLRGDINVCVVGDPSTAKSQFLKHVEEFCPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGAL 447

  Fly   394 VLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYK 458
            :|||.||.||||||||...|:.||||.|||..::|:|||:.|:||||.|:|||||||.||||:.|
Zfish   448 MLADNGVCCIDEFDKMETRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSGRYDRSK 512

  Fly   459 TPMENIGLQDSLLSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSL 523
            :..:|:.|...::|||||.|:::|..:...|..|:..:|.:|
Zfish   513 SLKQNVNLTAPIMSRFDLFFILVDDCNEVTDYAIARRIVDLH----------------------- 554

  Fly   524 SFVSSSEEKKDTEVYEKYDALLHGKSRQRHEKILSVEFMRKYIHIAKCMKPKLGEQACEAIANEY 588
               |..|...|                    ::.|::.:|:|:..|:..|||:.:::.|.|..:|
Zfish   555 ---SRIENSVD--------------------RVYSLDEIRRYLLFARQFKPKISKESEEFIVEQY 596

  Fly   589 SRLRSQEAVETDVARTQ-PITARTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVL 652
            .|||.::.  :.|.::. .||.|.||:|||||.:.||......|.......|..|:.    |.::
Zfish   597 KRLRQRDG--SGVTKSAWRITVRQLESLIRLSESMARMHCCDEVQPKHVKEAFRLLN----KSII 655

  Fly   653 DKDRPS---KRRRNSGSDAEDDN 672
            ..:.|.   .:......:.|:||
Zfish   656 RVETPDVNLDQEEEEAMEEEEDN 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	20/93 (22%)
Mcm3	NP_511048.2	MCM	106..648	CDD:214631	190/594 (32%)
mcm6	NP_001076318.1	MCM_N	27..137	CDD:291233	27/121 (22%)
		MCM	117..655	CDD:214631	191/599 (32%)
		P-loop_NTPase	<445..532	CDD:304359	52/86 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820