DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm3 and mcm6l

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001020704.1	Gene:	mcm6l / 564982	ZFINID:	ZDB-GENE-050913-141	Length:	824	Species:	Danio rerio

Alignment Length:	894	Identity:	237/894 - (26%)
Similarity:	411/894 - (45%)	Gaps:	166/894 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 HEGEQFIKDIQREYVDFLDDEEDQ---GIYAGHVKDMIAEKSKRLIVNVNDLKRKNPQRALGLLS 64
            |..::..:..|:.:::||::.:|:   .:|....:::|..:...|.|:.::::..|.|.|..:..
Zfish    11 HVRDELSEKCQKLFLEFLEEFQDKNGDALYLSDAQELIRPERNTLTVSFSNIEHYNQQLATTIQE 75

  Fly    65 NAADEQLAFGRALKEYASTVDPGYAKMHEDLFVGFEGCFGNRHVTPRSLTSIYLGNMVCVEGIVT 129
            ..........||::.:|.  |.|.....::.:|.|.. |.:|... |.|:::.:|.::.:.|.|.
Zfish    76 EYYRVYPFLCRAVRHFAR--DHGNIPPSKEFYVAFSE-FPSRQKI-RELSTVRIGTLLRISGQVV 136

  Fly   130 KVSLIRPKVVRSVHYCPNTRKVM-----ERKYTDLTSFEAVPSGAAYPT-KDEDGNLLETEYGLS 188
            :...:.|::|.....|.:.:.|:     :.|||.       |:....|. .:....:|:|  ..|
Zfish   137 RTHPVHPELVSGTFLCLDCQSVIKDVEQQFKYTQ-------PTICKNPVCANRRRFMLDT--NKS 192

  Fly   189 VYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSYRCLP----------- 242
            .:.|.|...|||...:.|.|.:||||:::...:.|:..:.|||....|:...:|
Zfish   193 RFVDFQKGRIQETQAELPRGSIPRSVEVILRAEAVETAQAGDRCDFTGTLVVVPDVSAMALAGTR 257

  Fly   243 --------GKRGGYTSG------------TFRTVLLANNIS----------LLSKESNLDISRED 277
                    ||.|..|.|            ::|...|||.::          |..::...:..:..
Zfish   258 AETSSRVTGKEGFETDGIQGLKALGVRELSYRLAFLANYVAPTNPRFGGKELRQEDQTAESVKNQ 322

  Fly   278 IMLCK-----KLAKNNDIFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTRLRGDINVL 337
            :.:.:     :::::.:::..|..||.|:|||:..:|:.||.:|.|||.|....||.|||||||.
Zfish   323 MTVLEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEIKRGILLMLFGGVAKTTMEGTSLRGDINVC 387

  Fly   338 LIGDPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVC 402
            ::||||.:|||.|::|.:.||||:.|:|:.||..||||||..|:|:.|..:||||::|||.||.|
Zfish   388 IVGDPSTSKSQFLKHVEDFAPRAVYTSGKASSAAGLTAAVVKDEESHEFVIEAGALMLADNGVCC 452

  Fly   403 IDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQ 467
            |||||||...|:.||||.|||..::|:|||:.|:||||.|:||||||:.|||::.|:..:|:.:.
Zfish   453 IDEFDKMDLKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPIDGRYNRAKSLKQNVNMS 517

  Fly   468 DSLLSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEK 532
            ..::|||||.|:::|..:...|..|:..:|.
Zfish   518 APIMSRFDLFFILVDECNEVTDYAIARRIVD---------------------------------- 548

  Fly   533 KDTEVYEKYDALLHGKSRQRHEKILSVEFMRKYIHIAKCMKPKLGEQACEAIANEYSRLRSQEAV 597
                        ||.::.:..|::.|.:.:::||..|:..:||:..:|.|.:.::|.|||.::..
Zfish   549 ------------LHARNVESVERVYSTDEIQRYILFARQFQPKITVEAQEFVVDQYKRLRQRDGG 601

  Fly   598 ETDVARTQPITARTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAY---------FKKVLD 653
            .|..:..: ||.|.||:::|||...||...|..|.......|..|:..:.         |.:..|
Zfish   602 GTTKSAWR-ITVRQLESMLRLSEGMARLYCSDEVQPKHVKEAFRLLNKSIIRVDSPDINFDQEHD 665

  Fly   654 KDRPSKRRRNSGSDAEDDNGEASSQRSPSRRSKRTRTATVGADSDEEDIEPPQPDAGDLTRR--- 715
            :|..:.:....|.:.|..||...:..           |....::|:.: :|.:|.|.....|
Zfish   666 EDNINDQNELFGKETEGQNGGDVNGH-----------AVEDMETDQTE-KPEKPAAAKPALRMSF 718

  Fly   716 -ETRRSLPARSVAMLMASPSSEEQSVATS--------TTEPAIISDARLGEFKNNLQR-LFREAR 770
             |.:|......:.|.......|:.|:..|        ..|..|.|:|.|...||.::| |:|...
Zfish   719 AEYKRVSNLLVLHMQKMEQLDEDSSLKKSELINWYLKEIESEIDSEAELVAKKNLIERVLYRLIN 783

  Fly   771 EQSLALARITTAINVGSQEPFTAGEIEAAVHRMTEDNQIMVADDIVFLI 819
            ...:.:....|.:.                 :::||.:..|::|..||:
Zfish   784 FDHIIIELTKTGLK-----------------KISEDGEEPVSEDDPFLV 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	17/85 (20%)
Mcm3	NP_511048.2	MCM	106..648	CDD:214631	181/602 (30%)
mcm6l	NP_001020704.1	MCM_N	23..133	CDD:291233	22/113 (19%)
		MCM	116..651	CDD:214631	180/591 (30%)
		P-loop_NTPase	<441..528	CDD:304359	49/86 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820