DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm3 and mcm6

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001016221.1	Gene:	mcm6 / 548975	XenbaseID:	XB-GENE-5870537	Length:	821	Species:	Xenopus tropicalis

Alignment Length:	890	Identity:	240/890 - (26%)
Similarity:	398/890 - (44%)	Gaps:	206/890 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QFIKD-----IQREYVDFLDD---EEDQGIYAGHVKDMIAEKSKRLIVNVNDLKRKNPQRALGLL 63
            |..||     .|:.:::||::   ::...:|....::::..:...|:||..|::..|.|.|..:.
Frog    17 QLFKDELSDKCQKLFLEFLEECKGKDGSNLYVSAAEELVRPERNTLVVNFTDIEYYNQQLATTIQ 81

  Fly    64 SNAADEQLAFGRALKEYASTVDPGYAKMHEDLFVGFEGCFGNRHVTPRSLTSIYLGNMVCVEGIV 128
            ...........||::.:|..:  |....:::.:|.|......:.:  |.|:|..:|.::.:.|.|
Frog    82 EEYYRVYPHLCRAVRSFARQM--GNIPANKEFYVAFSDFPARQKI--RELSSAKIGTLLRISGQV 142

  Fly   129 TKVSLIRPKVVRSVHYCPNTRKVM-----ERKYTDLTSFEAVPSGAAYPT-KDEDGNLLETEYGL 187
            .:...:.|::|.....|.:.:.|:     :.:||.       |:....|. .:.....|:|  ..
Frog   143 VRTHPVHPELVSGTFLCMDCQSVVKDVEQQFRYTQ-------PTICKNPVCANRRRFTLDT--NK 198

  Fly   188 SVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSYRCLP---------- 242
            |.:.|.|.:.|||...:.|.|.:||||:|:...:.|:....|||....|:...:|
Frog   199 SRFVDFQKVRIQETQAELPRGAIPRSVEIILRAEAVETAMAGDRCDFTGTLIVVPDISALAAGDA 263

  Fly   243 ---------GKRGGYTSG------------TFRTVLLANNISLLS-KESNLDISRED-------- 277
                     |..|..:.|            ::|...||.::...: :....|:..||
Frog   264 RMETGAKVTGGEGFNSEGVQGLKALGVRDLSYRLAFLACHVGATNPRFGGKDLREEDQTAESIKN 328

  Fly   278 ---IMLCKK---LAKNNDIFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTRLRGDINV 336
               :...:|   ::::.:::..|..||.|:|||:..:|:.:|.:|.|||.|....||.|||||||
Frog   329 QMTVQEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEIKRGVLLMLFGGVPKTTMEGTSLRGDINV 393

  Fly   337 LLIGDPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVV 401
            .::||||.:|||.|::|...:|||:.|:|:.||..||||||..|:|:.|..:||||::|||.||.
Frog   394 CIVGDPSTSKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVKDEESHEFVIEAGALMLADNGVC 458

  Fly   402 CIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGL 466
            ||||||||...|:.||||.|||..::|:|||:.|:||||.|:|||||||.|||::.|:...|:.|
Frog   459 CIDEFDKMDLKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVGGRYERSKSLKHNVNL 523

  Fly   467 QDSLLSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEE 531
            ...::|||||.|:::|..:...|..|:..:|.
Frog   524 SAPIMSRFDLFFILVDECNEVTDYAIARRIVD--------------------------------- 555

  Fly   532 KKDTEVYEKYDALLHGKSRQRHEKILSVEFMRKYIHIAKCMKPKLGEQACEAIANEYSRLRSQEA 596
                         ||.::.:..|::.|:|.:::|:..|:..:||:.::|.|.|..:|.|||.::.
Frog   556 -------------LHARNEESIERVYSIEDIQRYLLFARQFQPKITKEAEEFIVEQYRRLRQRDG 607

  Fly   597 VETDVARTQ-PITARTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDKDRPSKR 660
              :.||::. .||.|.||:|||||.:.||...|..|.......|..|:.    |.::..|.|
Frog   608 --SGVAKSSWRITVRQLESLIRLSESMARMHCSDEVQPKHVKEAFRLLS----KSIIRVDTP--- 663

  Fly   661 RRNSGSDAEDDNGEASSQRSPSRRSKRTRTATVGADSDEEDIEPPQPDAGDLTRRETRRSLPARS 725
                  |...|.||                       ||:::|           .|...
Frog   664 ------DVSFDQGE-----------------------DEKNVE-----------EEVNN------ 682

  Fly   726 VAMLMASPSSEEQSVATSTTEPAIISD---------ARLGEFK--NNLQRLFREAREQSLALARI 779
                 |:.::.|:::.|:..||  |:|         ....|:|  :||..|..:..|:......:
Frog   683 -----ANLNNGEEAMETNQDEP--INDKPSTNAGLKMSFAEYKQISNLLVLHMQKMEEVEEECHL 740

  Fly   780 TTAINVG------SQEPFTAGE-------IEAAVHRMTEDNQIMV 811
            ||...|.      ..|..|..|       ||..:||:...:.|::
Frog   741 TTTDLVNWYLKEMEAEIETETELILKKRLIEKVIHRLINYDHILI 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	16/85 (19%)
Mcm3	NP_511048.2	MCM	106..648	CDD:214631	185/594 (31%)
mcm6	NP_001016221.1	MCM_N	31..117	CDD:379644	16/87 (18%)
		MCM	123..658	CDD:214631	186/597 (31%)
		Arginine finger	529..532		2/2 (100%)
		MCM6_C	710..819	CDD:375690	17/76 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920