DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm3 and Mcmdc2

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_006237843.1	Gene:	Mcmdc2 / 500392	RGDID:	1561068	Length:	689	Species:	Rattus norvegicus

Alignment Length:	567	Identity:	114/567 - (20%)
Similarity:	192/567 - (33%)	Gaps:	162/567 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 KYTD----LTSFEAVP--SGAAY-----PTKDEDGNL------------LETEYGLSVYKDHQTL 196
            |||.    |.|.|..|  .|..|     |...|...:            |:.:....|..|.|.:
  Rat   150 KYTQGARFLCSDEVCPFSKGFQYIRVHVPGATESATVRNDFLCRLCSSSLQEDRKFRVLGDKQII 214

  Fly   197 TI---------QEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSYRCLPGKRGGYTSGT 252
            .|         |..|:..|...  :|:.:...|:||::.|.|:..:|:|...|:.         |
  Rat   215 EIITTKVLHAFQGDPKNQPFRF--QSLSVFLRDELVNKMKIGNEYKIIGIPVCVK---------T 268

  Fly   253 FRTVLL--ANNISLLSKESNLDISREDIMLCKKLAKNNDIFELLSKSL--APSIHGHAYVKQAI- 312
            .:|.|.  ||:|:..:.:....||  |...|        :..|.|.|.  ..:|..:.:....:
  Rat   269 SQTALCVEANSITPYTAKVPSGIS--DNFRC--------LLSLTSSSCWRFTAILANVFASHIVP 323

  Fly   313 --------LCLLLGGVEKILPNGTRLRGDINVLLIGDPSVAKSQLLRYVLNTAPRAI-------- 361
                    ||||:..|:....:..| ...:::|:|...::...:||.:.:|...|.|
  Rat   324 LGTYNLLKLCLLMSLVQTRDCSSER-ENCLDILVITSDTLLVDRLLNFSMNLVSRGIRHPVCTEV 387

  Fly   362 -PTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEF-----DKMSDIDRTAIHEV 420
             ||..|...|            ||...::||:.:||..||..|.:.     ||:..     :...
  Rat   388 FPTVSRDKYG------------TGAVSIQAGSALLARGGVCFIGDLTSHKKDKLEQ-----LQSA 435

  Fly   421 MEQGRVTISKAG--------IHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLL 477
            :|...||:...|        ...:...:||       .:...|...:...|:....:|:.:.|..
  Rat   436 LESRSVTVFIPGKKFGDDFDQQMTFPIQCS-------FWSFVDMDSSSRRNVQKASTLIGQMDCS 493

  Fly   478 FVMLDVIDS-----DVDQMISDHVVR---MHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKD 534
            .:..::.::     :..:....|.:.   .|..:...:..|.|      |..|..|.
  Rat   494 LIPANLAEAFGLLVNCKESSPCHPLLPTVQHTLKKAVDPKGPP------YLASKQFT-------- 544

  Fly   535 TEVYEKYDALLHGKSRQRHEKILSVEFMRKYIHIAKCMKPKLGEQACEAIANEYSRLRSQEAVET 599
            ||.:||..|.         .|.|:|||                  :.||....:....:...:.|
  Rat   545 TEDFEKLLAF---------AKNLNVEF------------------SLEAERMIHGYYLASRRIRT 582

  Fly   600 DVARTQPITARTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFA 646
            |......::|..|:.|:.||.||||..:...|..:|...|..|.:.:
  Rat   583 DSIHGSKLSANALKYLVSLSEAHARLNLRNKVLREDVLIAALLFEIS 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644
Mcm3	NP_511048.2	MCM	106..648	CDD:214631	114/567 (20%)
Mcmdc2	XP_006237843.1	MCM	<389..630	CDD:278895	59/306 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810