DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm3 and rec

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001262615.1	Gene:	rec / 49241	FlyBaseID:	FBgn0003227	Length:	885	Species:	Drosophila melanogaster

Alignment Length:	762	Identity:	189/762 - (24%)
Similarity:	319/762 - (41%)	Gaps:	132/762 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 DQGIY----AGHVKDMIAEKSKRLIVNVNDLKRKNPQRALGLLSNA-----ADEQLAFGRALKEY 80
            |:|.:    ||...|   .:.|.:..::::..|::|.|.||.||.|     .:.||....:....
  Fly   155 DRGFFPLCAAGIKSD---AQLKEVWPSLSEDIREHPLRTLGTLSLAMHTVVVNHQLDCNDSTTAM 216

  Fly    81 ASTVD------PGYAKMH--EDLFVGFEGCFGNRHVTPRSLTSIYLGNMVCVEGIVTKVSLIRPK 137
            .||.:      |...|::  .|.||..|...|..|....:|.||        .|.|:.|......
  Fly   217 VSTPEQYVLPTPRVRKIYARPDDFVPVESIEGISHSRVDTLFSI--------RGFVSNVGEPSYS 273

  Fly   138 VVRSVHYCPNTRKVMERKYTDLTSFEAVPSGAAYPTK-------DEDGNLLETEY---------- 185
            :......|  :|..||.......:|:..|    |..|       ||...|..:.|
  Fly   274 LTWQAFRC--SRCQMEIAMRQRGTFQPRP----YQCKRSECVARDEFVPLRSSPYTRLSIRQIIR 332

  Fly   186 ----GLSVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSYRCL---PG 243
                .|::..|.:|             .:|..:|:....||||..:.|..|.:.|..:..   ..
  Fly   333 VEESSLNLVHDFET-------------SMPAEMDVELRHDLVDAVRVGQEVVVTGILKLQELGDD 384

  Fly   244 KRGGYTSGTFRTVLLANNI---SLLSKESNLDISREDIMLCKKLAKNNDIFELLSKSLAPSIHGH 305
            ...|.||...:..|.|.:|   |.:.:|    .|..|:.....:....:.|:||.:|:||.::||
  Fly   385 TTTGDTSNQMQPYLKAVSIRDASSIKRE----FSERDLEAIVMINAEPNSFKLLVQSIAPEVYGH 445

  Fly   306 AYVKQAILCLLLGGVEKILPNGTRLRGDINVLLIGDPSVAKSQLLRYVLNTAPRAIPTTG-RGSS 369
            ...|.|.|..||||      .|..... |||||:|||.:.|:::|:.....|.|....:| ||:.
  Fly   446 ELPKAACLLSLLGG------KGAETEA-INVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQ 503

  Fly   370 G---VGLTAAVTTDQETGERRLEAGAMVLADRGVVC-IDEFDKMSDIDRTAIHEVMEQGRVTISK 430
            .   :|:|.|     ...:|.|:||::::|..|..| :|:.||::. .:..:.:.::...|.:..
  Fly   504 SAQQLGVTFA-----GRNKRVLQAGSLMMASGGGHCTLDDVDKLAS-KQAVLLQCLQSEEVNLPL 562

  Fly   431 AGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVIDSDVDQMISDH 495
            ||..||..|:.||:|.|||..|:||:.:..::||.:..|||..|.|::::||. .|:.|..::.|
  Fly   563 AGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDK-PSERDMSLTAH 626

  Fly   496 VVRMHRYRNPKEADGEPLSMGSSYADSLSFVS-------------SSEEKKDTEVYEKYDALLHG 547
            |..:|.....:.......::....:||:..||             .:|:..|:.:.:.||.
  Fly   627 VRALHAGARKRARIAARYALKPKMSDSMCEVSLNVPAAGKDDDTIKTEDDNDSIMQQDYDL---- 687

  Fly   548 KSRQRHEKILSVE---------FMRKYIHIAKC-MKPKLGEQACEAIANEYSRLRSQEAVETDVA 602
               .:..::|..|         .::|::..|:. :.|.|.|.|..|:...:..|:....::.||
  Fly   688 ---DKRLEVLPEEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLELKGSCNLDEDV- 748

  Fly   603 RTQPITARTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDKDRPSKRRRNSGSD 667
             :..|.|..|..:|.||.|.||..:|..|:.......|.|:..:..:..| |:..|::....|..
  Fly   749 -SSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQTSL-KEGSSRQGTRGGGG 811

  Fly   668 AEDDNGEASSQRSPSRRSKRTRTATVGADSDE-EDIEPPQPDAGDLT 713
            |....|:::..|:....:|| |:|.:|....| ::::.....||.||
  Fly   812 AGGGAGKSAQLRNFLELTKR-RSAALGRRIFEFDELKEIGTRAGILT 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	23/92 (25%)
Mcm3	NP_511048.2	MCM	106..648	CDD:214631	147/596 (25%)
rec	NP_001262615.1	RNR_PFL	<117..200	CDD:299130	14/47 (30%)
		MCM	243..792	CDD:214631	149/602 (25%)
		P-loop_NTPase	468..606	CDD:304359	47/143 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446143
Domainoid	1	1.000	52	1.000	Domainoid score	I661
eggNOG	1	0.900	-	-		E1_COG1241
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11630
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850