Protein Alignment Mcm3 and mcm2

DIOPT Version :10

• Sequence 1: NP_511048.2
• Gene: Mcm3 / 31449
• FlyBaseID: FBgn0284442
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_001006772.1
• Gene: mcm2 / 448458
• XenbaseID: XB-GENE-999974
• Length: 884
• Species: Xenopus tropicalis
• Alignment Length: 782
• Identity: 259/782 - (33%)
• Similarity: 379/782 - (48%)
• Gaps: 132/782 - (16%)

  Fly     4 EGEQFIKDIQ----------REYV--------------DFLD---DEEDQGIYAGHVKDMIAEKS 41
            |.|:.|:.|:          ||:|              :||.   ||....::...:.||..|..
 Frog   148 EDEEMIESIENLEDMKGHTVREWVSMAATRLEIYHRFKNFLRTHVDEHGHNVFKEKISDMCKENK 212

  Fly    42 KRLIVNVNDLKRKNPQRALGLLSNAADEQLAFGRALKEYASTVDPGYAKMHEDLFVGFEGCFGNR 106
            :.|:||..||..:....|..|....|:....|..|.||....:.|.|.::..::.|...
 Frog   213 ESLVVNYEDLAAREHVLAYFLPEAPAEMLKIFDEAAKEVVLVMYPKYDRIAREIHVRIS------ 271

  Fly   107 HVTP-----RSLTSIYLGNMVCVEGIVTKVSLIRPKVVRSVHYCPNTRKVMERKYTDLTSFEAVP 166
            |: |     |||..::|..::...|:||..:.:.|::....:.|.....::...:.  :..:.|.
 Frog   272 HL-PLVEELRSLRQLHLNQLIRTSGVVTCCTGVLPQLSMVKYNCNKCNFILGPFFQ--SQNQEVK 333

  Fly   167 SGAAYPTKDEDG----NLLETEYGLSVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCK 227
            .|:. |.....|    |:.||     ||:::|.:||||.|.|..||:||||.|.:...||||.||
 Frog   334 PGSC-PECQSLGPFEINMEET-----VYQNYQRITIQESPGKVAAGRLPRSKDAILLADLVDSCK 392

  Fly   228 PGDRVQIVGSYRCLPGKRGGYTSG--------TFRTVLLANNISLLSKESNL---DISREDIMLC 281
            |||.:::.|:|      ...|...        .|.||:|||:|:  .|:..:   :::.||:...
 Frog   393 PGDEIELTGTY------HNNYDGSLNTANGFPVFATVILANHIT--KKDDKVAVGELTDEDVKAI 449

  Fly   282 KKLAKNNDIFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGT-RLRGDINVLLIGDPSVA 345
            ..|:|:..|.|.:..|:||||:||..:|:.:...|.||..| .|.|. ::||||||||.|||..|
 Frog   450 VALSKDERIGERIFASIAPSIYGHEDIKRGLALALFGGEAK-NPGGKHKVRGDINVLLCGDPGTA 513

  Fly   346 KSQLLRYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMS 410
            |||.|:||...|.||:.|||:|:|.|||||.|.....|.|..|||||:|||||||..|||||||:
 Frog   514 KSQFLKYVEKVASRAVFTTGQGASAVGLTAYVQRHPVTKEWTLEAGALVLADRGVCLIDEFDKMN 578

  Fly   411 DIDRTAIHEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFD 475
            |.|||:|||.|||..::||||||..||.|||:::||:||:.||||...|..||:.|.:.::||||
 Frog   579 DQDRTSIHEAMEQQSISISKAGIVTSLQARCTIIAASNPIGGRYDPSLTFSENVDLTEPIVSRFD 643

  Fly   476 LLFVMLDVIDSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKDTEVYEK 540
            :|.|:.|.:|...|:|::..||..|...:|...|   ::.|..:|...:|   ..|....||.:|
 Frog   644 ILCVVRDTVDPVQDEMLARFVVGSHIKHHPSSKD---IANGEEFALPNTF---GVEPLPQEVLKK 702

  Fly   541 YDALLHGKSRQRHEKILSVEFMRKYIHIAKCMKPKLGEQACEAIANEYSRLRSQEAVETDVARTQ 605
            |                 :.:.::.||      |||.:...:.:|..||.||.:......:
 Frog   703 Y-----------------IMYSKEKIH------PKLNQMDQDKVAKMYSDLRKESMATGSI---- 740

  Fly   606 PITARTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDKDRPSKRRRNSGSDA-- 668
            |||.|.:|::||::.||||..:...|..||.:.||.::    .:..:|..:.|..|....:.|
 Frog   741 PITVRHIESMIRMAEAHARMHLRDYVVEDDVNMAIRVM----LESFIDTQKFSVMRSMRKTFARY 801

  Fly   669 ---EDDNGE---------ASSQRSPSRRSKRTRTATVGADSDEEDIEPPQPDAGDLTRRETRRSL 721
               ..||.|         .:.|.|..|.       ..||..|  .||.|:.|..|..|:....:|
 Frog   802 LAFRRDNNELLLFVLKQLVAEQTSYQRN-------RYGAQQD--TIEVPEKDLVDKARQINIHNL 857

  Fly   722 PA 723
            .|
 Frog   858 SA 859

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	13..101	CDD:464206	25/114 (22%)
		MCM	106..648	CDD:214631	209/562 (37%)
mcm2	NP_001006772.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..61
		MCM2_N	56..167	CDD:403724	4/18 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	120..151		1/2 (50%)
		MCM_N	182..272	CDD:464206	22/95 (23%)
		MCM	276..783	CDD:214631	207/560 (37%)
		Arginine finger	640..643		2/2 (100%)