Protein Alignment Mcm3 and MCM7

DIOPT Version :9

• Sequence 1: NP_511048.2
• Gene: Mcm3 / 31449
• FlyBaseID: FBgn0284442
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_005907.3
• Gene: MCM7 / 4176
• HGNCID: 6950
• Length: 719
• Species: Homo sapiens
• Alignment Length: 705
• Identity: 234/705 - (33%)
• Similarity: 359/705 - (50%)
• Gaps: 129/705 - (18%)

  Fly     5 GEQFIKDIQRE----YVDFLDDEEDQ---------------GIYAGHVKDMIAEKSKRLIVNVND 50
            |.|.::...||    |||..|..||.               .::|..|::::.:..:|.:||
Human    34 GNQLVRLAHREQVALYVDLDDVAEDDPELVDSICENARRYAKLFADAVQELLPQYKEREVVN--- 95

  Fly    51 LKRKNPQRALGLLSNAADEQLAFGRALKEYASTVDPGYAKMHEDLF---------VGFEGCFGNR 106
                         .:..|..:.. |.:.|..|. |||..:..::.:         :.|:|...|:
Human    96 -------------KDVLDVYIEH-RLMMEQRSR-DPGMVRSPQNQYPAELMRRFELYFQGPSSNK 145

  Fly   107 HVTPRSLTSIYLGNMVCVEGIVTKVSLIRPKVVRSVHYCPNTRKVMERKYTDLTSFEAVPSGAAY 171
            ....|.:.:..:|.:|.|.||||:||.::||:|.:.:.|..         ....:::.:.|....
Human   146 PRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQ---------CGAETYQPIQSPTFM 201

  Fly   172 P----------TKDEDGNLLETEYGLSVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRC 226
            |          |....|.|.....| |.:...|.:.:||..::.|.|.:|||:.::.:.:.....
Human   202 PLIMCPSQECQTNRSGGRLYLQTRG-SRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIA 265

  Fly   227 KPGDRVQIVGSYRCLPGKRGGY---TSGTF-RTVLLANNISLLSK----ESNL-DISREDIMLCK 282
            :|||.|.:.|.:  ||..|.|:   ..|.. .|.|.|:.|..::|    ||.. :::||::   :
Human   266 QPGDHVSVTGIF--LPILRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAGELTREEL---R 325

  Fly   283 KLAKNNDIFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTRLRGDINVLLIGDPSVAKS 347
            ::|: .|.:|.|:.|:||.|:||..||:|:|.||:|||:: .|.|.::||:||:.|:|||.||||
Human   326 QIAE-EDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQ-SPRGMKIRGNINICLMGDPGVAKS 388

  Fly   348 QLLRYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDI 412
            |||.|:...|||:..|||||||||||||||..|..:||..||.||:||||:||.||||||||::.
Human   389 QLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEA 453

  Fly   413 DRTAIHEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLL 477
            |||||||||||..::|:||||..:||||||:||||||.||||:..::..:||.|..:||||||||
Human   454 DRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLL 518

  Fly   478 FVMLDVIDSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKDTEVYEKYD 542
            :::.|..|.|.|..::.|:..:|::.....:..|||.|
Human   519 WLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDM--------------------------- 556

  Fly   543 ALLHGKSRQRHEKILSVEFMRKYIHIAKCMKPKLGEQACEAIANEYSRLRSQEAVETDVARTQPI 607
                             :.||:||.:.:..:|.:.|...:.|...|..:|.:.....|...|
Human   557 -----------------KLMRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATYT--- 601

  Fly   608 TARTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDKDRPSKRRR 662
            :||||..::|||||.||.||...|..:|.:.||.|::.:....:.||.:.::.:|
Human   602 SARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQR 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	17/106 (16%)
		MCM	106..648	CDD:214631	206/560 (37%)
MCM7	NP_005907.3	MCM_N	10..93	CDD:405270	13/58 (22%)
		MCM	145..641	CDD:214631	206/559 (37%)
		Arginine finger	513..516		2/2 (100%)
		Interaction with RAD17. /evidence=ECO:0000269|PubMed:15538388	521..564		13/86 (15%)
		Interaction with ATRIP	577..719		26/83 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820