DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm3 and MCM6

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_005906.2	Gene:	MCM6 / 4175	HGNCID:	6949	Length:	821	Species:	Homo sapiens

Alignment Length:	883	Identity:	244/883 - (27%)
Similarity:	398/883 - (45%)	Gaps:	191/883 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EQFIKDIQREYVDFLDDEEDQGIYAGHVK------DMIAEKSKRLIVNVNDLKRKNPQRALGLLS 64
            ::..:..|:.::|||::.:...   |.:|      ::|..:...|:|:..||::.|.|     ||
Human    20 DEVAEKCQKLFLDFLEEFQSSD---GEIKYLQLAEELIRPERNTLVVSFVDLEQFNQQ-----LS 76

  Fly    65 NAADEQL-----AFGRALKEYASTVDPGYAKMHEDLFVGFEGCFGNRHVTPRSLTSIYLGNMVCV 124
            ....|:.     ...||||.:..  |.....:.:|.:|.|:. ...||.. |.|||..:|.:..:
Human    77 TTIQEEFYRVYPYLCRALKTFVK--DRKEIPLAKDFYVAFQD-LPTRHKI-RELTSSRIGLLTRI 137

  Fly   125 EGIVTKVSLIRPKVVRSVHYCPNTRKVM-----ERKYTDLTSFEAVPSGAAYPT-KDEDGNLLET 183
            .|.|.:...:.|::|.....|.:.:.|:     :.|||.       |:....|. .:....||:|
Human   138 SGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQ-------PNICRNPVCANRRRFLLDT 195

  Fly   184 EYGLSVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVG--------SYRC 240
              ..|.:.|.|.:.|||...:.|.|.:|||::::...:.|:..:.||:....|        |...
Human   196 --NKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVPDVSKLS 258

  Fly   241 LPGKRG----------GY-TSG------------TFRTVLLANNIS----------LLSKESNLD 272
            .||.|.          || |.|            ::|.|.||..::          |..:|...:
Human   259 TPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFGGKELRDEEQTAE 323

  Fly   273 ISREDIMLCK------KLAKNNDIFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTRLR 331
             |.::.|..|      :::::.:::..|..||.|:|||:..||:.:|.:|.|||.|....||.||
Human   324 -SIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLR 387

  Fly   332 GDINVLLIGDPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLA 396
            |||||.::||||.||||.|::|...:|||:.|:|:.||..||||||..|:|:.|..:||||::||
Human   388 GDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLA 452

  Fly   397 DRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPM 461
            |.||.||||||||...|:.||||.|||..::|:|||:.|:||||.|:||||||:.|.||:.|:..
Human   453 DNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPISGHYDRSKSLK 517

  Fly   462 ENIGLQDSLLSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFV 526
            :||.|...::|||||.|:::|..:...|..|:..:|.:|
Human   518 QNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLH-------------------------- 556

  Fly   527 SSSEEKKDTEVYEKYDALLHGKSRQRHEKILSVEFMRKYIHIAKCMKPKLGEQACEAIANEYSRL 591
            |..||..|                    ::.|::.:|:|:..|:..|||:.:::.:.|..:|..|
Human   557 SRIEESID--------------------RVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKHL 601

  Fly   592 RSQEAVETDVARTQ-PITARTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDKD 655
            |.::.  :.|.::. .||.|.||::||||.|.||......|.......|..|:.    |.::..:
Human   602 RQRDG--SGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLN----KSIIRVE 660

  Fly   656 RPSKRRRNSGSDAEDD------------NGEASSQRSPSRRSKRTRTATVGADSDEEDIEPPQPD 708
            .|     :...|.|::            ||.|.|....:           |.:...|||......
Human   661 TP-----DVNLDQEEEIQMEVDEGAGGINGHADSPAPVN-----------GINGYNEDINQESAP 709

  Fly   709 AGDLTRRETRRSLPARSVAMLMASPSSEEQSVATSTTEPAIISDARLGEFKNNLQRLFREAREQS 773
            ...|....:.....:..:.:.:.....||...|...:|   :.:..|.|.::.:     ::.|:.
Human   710 KASLRLGFSEYCRISNLIVLHLRKVEEEEDESALKRSE---LVNWYLKEIESEI-----DSEEEL 766

  Fly   774 LALARITTAINVGSQEPFTAGEIEAAVHRMTEDNQIMV 811
            :...||                ||..:||:|..:.:::
Human   767 INKKRI----------------IEKVIHRLTHYDHVLI 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	23/93 (25%)
Mcm3	NP_511048.2	MCM	106..648	CDD:214631	193/595 (32%)
MCM6	NP_005906.2	MCM_N	27..114	CDD:405270	23/96 (24%)
		MCM	119..657	CDD:214631	194/600 (32%)
		Arginine finger	528..531		2/2 (100%)
		MCM6_C	713..817	CDD:408078	15/100 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820