Protein Alignment Mcm3 and MCM5

DIOPT Version :9

• Sequence 1: NP_511048.2
• Gene: Mcm3 / 31449
• FlyBaseID: FBgn0284442
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_006730.2
• Gene: MCM5 / 4174
• HGNCID: 6948
• Length: 734
• Species: Homo sapiens
• Alignment Length: 826
• Identity: 250/826 - (30%)
• Similarity: 379/826 - (45%)
• Gaps: 174/826 - (21%)

  Fly     2 AHEGEQFIKDIQREYVDFLDDEE---DQGIYAGHVKDMIAEKSKR--------LIVNVNDLKR-- 53
            |.||:.....:||.:.:||....   |:..:....:|.:    ||        :.|.:.||..
Human    21 ADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDEL----KRHYNLGEYWIEVEMEDLASFD 81

  Fly    54 --------KNPQRALGLLSNAADEQLAFGRALKEYASTVD---PGYAKMHEDLFVGFEGCFGNRH 107
                    |.|...|.||..||          ||.|..|.   |...::.:|:.|..:.     .
Human    82 EDLADYLYKQPAEHLQLLEEAA----------KEVADEVTRPRPSGEEVLQDIQVMLKS-----D 131

  Fly   108 VTP---RSLTSIYLGNMVCVEGIVTKVSLIRPKVVRSVHYCPNTRKVMERKYTDLTSFEAVP--S 167
            .:|   |||.|..:.::|.:.||:...|.:|.|..|....|.:.|..       ||:....|  .
Human   132 ASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNT-------LTNIAMRPGLE 189

  Fly   168 GAAYPTKDEDGNLLETEYGLSVY---------KDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLV 223
            |.|.|.|.........:..|..|         .|.|||.:||:|:..|.|::||.:.:.||..|.
Human   190 GYALPRKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLC 254

  Fly   224 DRCKPGDRVQIVGSYRCLPGKRGGYTSGTFR----TVLLANNISLLSKESNLD---------ISR 275
            |:..||:||.|:|.|..   |:.|.|:...|    ..:.::.|.:|..:.:.|         :|.
Human   255 DKVVPGNRVTIMGIYSI---KKFGLTTSRGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGAVSP 316

  Fly   276 EDIMLCKKLAKNNDIFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTRLRGDINVLLIG 340
            ::....::||...:::|::|||:||||.|...:|:||.|||.||..|.||:|...|||||:|::|
Human   317 QEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLG 381

  Fly   341 DPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDE 405
            ||..||||||::|...:|..:.|:|:|||..||||:|..|..:....:|.|||||||.|||||||
Human   382 DPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDE 446

  Fly   406 FDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSL 470
            ||||.:.||.||||.|||..::|:||||..:||:|||||||||.|:||:|:.|.. :||....::
Human   447 FDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKGE-DNIDFMPTI 510

  Fly   471 LSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKDT 535
            |||||::|::.|..:.:.|.|::.||:.:|                   ..:|:...:.|.:.|.
Human   511 LSRFDMIFIVKDEHNEERDVMLAKHVITLH-------------------VSALTQTQAVEGEIDL 556

  Fly   536 EVYEKYDALLHGKSRQRHEKILSVEFMRKYIHIAKCMKPKLGEQACEAIANEYSRLRS---QEAV 597
            ...:|:.|                     |..: || .|:|..:|.|.:.|.|..:||   |...
Human   557 AKLKKFIA---------------------YCRV-KC-GPRLSAEAAEKLKNRYIIMRSGARQHER 598

  Fly   598 ETDVARTQPITARTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDKDRPSKRRR 662
            ::|...:.|||.|.||.::|::.|.::.::....|..|...|:.|.|.:    .||.........
Human   599 DSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVS----TLDAALSGTLSG 659

  Fly   663 NSGSDAEDDNGEASSQRSPSRRSKR-TRTATVGADSDEEDIEPPQPDAGDLTRRETRRSLPARS- 725
            ..|..:::|      |...||..|: .|...:|:...|..|          .:..|::..|..:
Human   660 VEGFTSQED------QEMLSRIEKQLKRRFAIGSQVSEHSI----------IKDFTKQKYPEHAI 708

  Fly   726 --VAMLMASPSSEEQSVATSTTEPAIISDARLGEFKNNLQR--LFR 767
              |..||                      .|.||.::.:||  |:|
Human   709 HKVLQLM----------------------LRRGEIQHRMQRKVLYR 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	23/106 (22%)
		MCM	106..648	CDD:214631	198/571 (35%)
MCM5	NP_006730.2	MCM_N	32..129	CDD:405270	25/110 (23%)
		MCM	133..649	CDD:214631	198/572 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820