DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm3 and MCM4

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_005905.2	Gene:	MCM4 / 4173	HGNCID:	6947	Length:	863	Species:	Homo sapiens

Alignment Length:	858	Identity:	245/858 - (28%)
Similarity:	386/858 - (44%)	Gaps:	202/858 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EQFIKDIQREYVDFLDDEED-------QGIYAGHVKDMIAEKSKRLIVNVNDLKR--KN------ 55
            |.|.:.:|| ::|.|..||:       :.:|...:.::.......|.||...:|.  ||
Human   164 ENFQRFLQR-FIDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNLYRQLI 227

  Fly    56 --PQRALGLLSNAADEQLAFGR---ALKEYASTVDPGYAKMHEDLFVGFEGCFGNRHVTPRSLTS 115
              ||..:.....|.:| :.|.|   ::.|:...|.|..|...:::          |::.|..
Human   228 SYPQEVIPTFDMAVNE-IFFDRYPDSILEHQIQVRPFNALKTKNM----------RNLNPED--- 278

  Fly   116 IYLGNMVCVEGIVTKVSLIRPKVVRSVHYCP----NTRKVMERKYTDLTSFEAVPS--GAAYPTK 174
              :..::.:.|:|.:.|.:.|::..:...|.    .||..|:|...      |.||  |..:.|
Human   279 --IDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMDRGRI------AEPSVCGRCHTT- 334

  Fly   175 DEDGNLLETEYGLSVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSYR 239
                :.:...:..|::.|.|.:.:||.||..||||.|.:|.:...:||||:.:|||||.:.|.||
Human   335 ----HSMALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYR 395

  Fly   240 CLP---GKRGGYTSGTFRTVL--------LANNISLLSKESNLDI-SREDIMLCKKLAKNNDIFE 292
            .:|   ..|.......::|.:        .|..:..|.:|:...: |.:.:.|.|:|::..||:|
Human   396 AVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYE 460

  Fly   293 LLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTR--LRGDINVLLIGDPSVAKSQLLRYVLN 355
            .|:.:|||||:.|..:|:.||..|.||..|...:..|  .|.:||:||.|||..:|||||:||.|
Human   461 RLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYN 525

  Fly   356 TAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEV 420
            ..||...|:|:|||.|||||.|..|.||.:..|:.||:||:|.|:.||||||||::..|:.:|||
Human   526 LVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEV 590

  Fly   421 MEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVID 485
            |||..::|:||||...||||.||||||||:..:::..||.:|||.|..:|||||||:|::||..|
Human   591 MEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQD 655

  Fly   486 SDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKDTEVYEKYDALLHGKSR 550
            ...|:.::.|:|.:: |::.::|:                    ||..|..|.:.|.|..|
Human   656 EAYDRRLAHHLVALY-YQSEEQAE--------------------EELLDMAVLKDYIAYAH---- 695

  Fly   551 QRHEKILSVEFMRKYIHIAKCMKPKLGEQACEAIANEYSRLRSQEAVETDVARTQPITA---RTL 612
                               ..:.|:|.|:|.:|:...|..:|.       :..::.:.:   |.|
Human   696 -------------------STIMPRLSEEASQALIEAYVDMRK-------IGSSRGMVSAYPRQL 734

  Fly   613 ETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDKDRPSKRRRNSGSDAEDDNGEASS 677
            |:||||:.|||:.|:|..|...|...|..|.:.|.              :.|.:|
Human   735 ESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREAL--------------KQSATD---------- 775

  Fly   678 QRSPSRRSKRTRTATVGADSDEEDIEPPQPDAGDLTRRETRRSLPARSVAMLMASPSSEEQSVAT 742
                      .||..|              |...||..              |::.|.:.:....
Human   776 ----------PRTGIV--------------DISILTTG--------------MSATSRKRKEELA 802

  Fly   743 STTEPAIISDARLGEFKNNLQRLFREAREQS-LALARITTAINVGSQEPFTAGEIEAAVHRMTED 806
            ...:..|:|..:....|  .|:||.:.|.|| :|:               |....|.|:..:.:|
Human   803 EALKKLILSKGKTPALK--YQQLFEDIRGQSDIAI---------------TKDMFEEALRALADD 850

  Fly   807 NQIMVADDIVFLI 819
            :.:.|....|.|:
Human   851 DFLTVTGKTVRLL 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	21/102 (21%)
Mcm3	NP_511048.2	MCM	106..648	CDD:214631	193/564 (34%)
MCM4	NP_005905.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..60
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..126
		MCM_N	163..263	CDD:405270	23/100 (23%)
		MCM	267..770	CDD:214631	193/593 (33%)
		Arginine finger	642..645		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820