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Protein Alignment Mcm3 and Mcm2

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_477121.1	Gene:	Mcm2 / 40973	FlyBaseID:	FBgn0014861	Length:	887	Species:	Drosophila melanogaster

Alignment Length:	686	Identity:	230/686 - (33%)
Similarity:	349/686 - (50%)	Gaps:	96/686 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 HEGEQFIK------DIQREYVDFLD---DEEDQGIYAGHVKDMIAEKSKRLIVNVNDLKRKNPQR 58
            |..::::.      :|...:..||.   ||.....|...::.|..:.....:|:..||..|....
  Fly   165 HSTKEWVSMLGPRTEIANRFQSFLRTFVDERGAYTYRDRIRRMCEQNMSSFVVSYTDLANKEHVL 229

  Fly    59 ALGLLSNAADEQL-AFGRALKEYASTVDPGYAKMHEDLFVGFEGCFGNRHVTP-----RSLTSIY 117
            |. .|..|..:.| .|.:..|:...::.|.|.::..::.|...       ..|     |:...::
  Fly   230 AY-FLPEAPFQMLEIFDKVAKDMVLSIFPTYERVTTEIHVRIS-------ELPLIEELRTFRKLH 286

  Fly   118 LGNMVCVEGIVTKVSLIRPKVVRSVHYCPNTRKVMERKYTDLTSFEAVPSGAAYPTKDEDG---- 178
            |..:|...|:||..:.:.|::....:.|.....|: ..:....:.|..|...  |.....|
  Fly   287 LNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVL-GPFVQSQNTEIKPGSC--PECQSTGPFSI 348

  Fly   179 NLLETEYGLSVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSYRCLPG 243
            |:.:|     :|:::|.:|:||.|.:.|||::|||.|::...||.|:|||||.:::.|.|
  Fly   349 NMEQT-----LYRNYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIY----- 403

  Fly   244 KRGGYTSG--------TFRTVLLANNISLL-SKESNLDISREDIMLCKKLAKNNDIFELLSKSLA 299
             ...|...        .|.||::||::.:. ||:....::.|||...:||:|:..|.|.:..|:|
  Fly   404 -TNNYDGSLNTDQGFPVFATVIIANHVVVKDSKQVVQSLTDEDIATIQKLSKDPRIVERVVASMA 467

  Fly   300 PSIHGHAYVKQAILCLLLGGVEKILPNGTRLRGDINVLLIGDPSVAKSQLLRYVLNTAPRAIPTT 364
            |||:||.|:|:|:...|.||..|......::|||||:|:.|||..||||.|:|....||||:.||
  Fly   468 PSIYGHDYIKRALALALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTT 532

  Fly   365 GRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTIS 429
            |:|:|.|||||.|..:..:.|..|||||:||||:||..|||||||:|.|||:|||.|||..::||
  Fly   533 GQGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISIS 597

  Fly   430 KAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVIDSDVDQMISD 494
            ||||..||.|||:|:|||||:.||||...|..||:.|.:.:|||||:|.|:.|..|...||.::.
  Fly   598 KAGIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAK 662

  Fly   495 HVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKDTEVYEKYDALLHGKSRQRHEKILSV 559
            .||..|...:|.|.:...|                ||.:...|.|                 :..
  Fly   663 FVVHSHMKHHPSEEEQPEL----------------EEPQLKTVDE-----------------IPQ 694

  Fly   560 EFMRKYIHIAK-CMKPKLGEQACEAIANEYSRLRSQEAVETDVARTQPITARTLETLIRLSTAHA 623
            :.:|:||..|| .::|||.....:.||..|::|| ||:..|.   :.|||.|.:|::||:|.|||
  Fly   695 DLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLR-QESFATG---SLPITVRHIESVIRMSEAHA 755

  Fly   624 RARMSKSVTIDDAHAAIELV--------QFAYFKKV 651
            |..:.::|...|...||.::        :|:..||:
  Fly   756 RMHLRENVMEADVSMAIRMMLESFIEAQKFSVMKKM 791

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.